Cognitive discernible factors between schizophrenia and schizoaffective disorder

Stip, Émmanuel; Sepehry, Amir Ali; Prouteau, Antoinette; Briand, Catherine; Nicole, Luc; Lalonde, Pierre; Lesage, Alain

doi:10.1016/j.bandc.2005.07.003

Cited by 56 publications

(41 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compared to the classic Stroop task, this task is more demanding attentional task employing two different instructions ("read and identify the word" and "identify the ink color of the word") and the subjects need to switch between these two tasks. Second, our sample included more schizoaffective patients (seven vs. one), who appear to be less impaired in certain aspects of cognitive functioning (Stip et al, 2005). Whether this is relevant for the present results cannot be resolved at this point, because too few studies have related the Stroop effect to the clinical dimensions of schizophrenia.…”

Section: Discussionmentioning

confidence: 89%

Stroop interference effect in schizophrenic patients: An electrophysiological approach

Markela-Lerenc

Schmidt-Kraepelin

Roesch-Ely

et al. 2009

International Journal of Psychophysiology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Stroop interference effect in schizophrenic patients: An electrophysiological approach

Markela-Lerenc

Schmidt-Kraepelin

Roesch-Ely

et al. 2009

International Journal of Psychophysiology

View full text Add to dashboard Cite

“…In the simple stage the yellow dot always appears in the same location, and in the five-choice stage in one out of five potential locations. The CANTAB RTI is often used to assess visuo-spatial and visuo-motor coordination abilities [57], motor speed [58], and understand sustained attention and reaction time [59]. …”

Section: Methodsmentioning

confidence: 99%

Study protocol: the Whitehall II imaging sub-study

et al. 2014

View full text Add to dashboard Cite

BackgroundThe Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study.Methods/designA total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012–2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60–85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study.DiscussionThe integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

show abstract

“…Some studies with small sample sizes suggest specific areas of more preserved cognition in schizo-affective disorder compared to schizophrenia (Goldstein et al 2005; Stip et al 2005); another reported similar impairments in processing speed in both groups, but abnormal P300 amplitude deficits only in schizophrenia (Mathalon et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Cognition in schizophrenia and schizo-affective disorder: impairments that are more similar than different

et al. 2013

View full text Add to dashboard Cite

Background Cognition is increasingly being recognized as an important aspect of psychotic disorders and a key contributor to functional outcome. In the past, comparative studies have been performed in schizophrenia and schizo-affective disorder with regard to cognitive performance, but the results have been mixed and the cognitive measures used have not always assessed the cognitive deficits found to be specific to psychosis. A set of optimized cognitive paradigms designed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS) Consortium to assess deficits specific to schizophrenia was used to measure cognition in a large group of individuals with schizophrenia and schizo-affective disorder. Method A total of 519 participants (188 with schizophrenia, 63 with schizo-affective disorder and 268 controls) were administered three cognitive paradigms assessing the domains of goal maintenance in working memory, relational encoding and retrieval in episodic memory and visual integration. Results Across the three domains, the results showed no major quantitative differences between patient groups, with both groups uniformly performing worse than healthy subjects. Conclusions The findings of this study suggests that, with regard to deficits in cognition, considered a major aspect of psychotic disorder, schizophrenia and schizo-affective disorder do not demonstrate major significant distinctions. These results have important implications for our understanding of the nosological structure of major psychopathology, providing evidence consistent with the hypothesis that there is no natural distinction between cognitive functioning in schizophrenia and schizo-affective disorder.

show abstract

Cognitive discernible factors between schizophrenia and schizoaffective disorder

Cited by 56 publications

References 10 publications

Stroop interference effect in schizophrenic patients: An electrophysiological approach

Stroop interference effect in schizophrenic patients: An electrophysiological approach

Study protocol: the Whitehall II imaging sub-study

Cognition in schizophrenia and schizo-affective disorder: impairments that are more similar than different

Contact Info

Product

Resources

About