Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome – A 6-month follow-up study

Kawatani, Junko; Mizuno, Kei; Shiraishi, Seishi; Takao, Miyuki; Joudoi, Takako; Fukuda, Sanae; Watanabe, Yasuyoshi; Tomoda, Akemi

doi:10.1016/j.braindev.2010.12.009

Cited by 35 publications

(42 citation statements)

References 50 publications

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“…Interestingly, a recent study in children with CFS found that treatment with both cognitive behavioral therapy and pharmacotherapy lead to improvements in attention (Kawatani et al, 2011). …”

Section: Neurocognitive Testing Demonstrates Specific Cognitive Deficmentioning

confidence: 99%

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Ocon¹

2013

Front. Physiol.

116

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Chronic Fatigue Syndrome (CFS) is defined as greater than 6 months of persistent fatigue that is experienced physically and cognitively. The cognitive symptoms are generally thought to be a mild cognitive impairment, but individuals with CFS subjectively describe them as “brain fog.” The impairment is not fully understood and often is described as slow thinking, difficulty focusing, confusion, lack of concentration, forgetfulness, or a haziness in thought processes. Causes of “brain fog” and mild cognitive impairment have been investigated. Possible physiological correlates may be due to the effects of chronic orthostatic intolerance (OI) in the form of the Postural Tachycardia Syndrome (POTS) and decreases in cerebral blood flow (CBF). In addition, fMRI studies suggest that individuals with CFS may require increased cortical and subcortical brain activation to complete difficult mental tasks. Furthermore, neurocognitive testing in CFS has demonstrated deficits in speed and efficiency of information processing, attention, concentration, and working memory. The cognitive impairments are then perceived as an exaggerated mental fatigue. As a whole, this is experienced by those with CFS as “brain fog” and may be viewed as the interaction of physiological, cognitive, and perceptual factors. Thus, the cognitive symptoms of CFS may be due to altered CBF activation and regulation that are exacerbated by a stressor, such as orthostasis or a difficult mental task, resulting in the decreased ability to readily process information, which is then perceived as fatiguing and experienced as “brain fog.” Future research looks to further explore these interactions, how they produce cognitive impairments, and explain the perception of “brain fog” from a mechanistic standpoint.

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Section: Neurocognitive Testing Demonstrates Specific Cognitive Deficmentioning

confidence: 99%

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Ocon¹

2013

Front. Physiol.

116

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Section: Introductionmentioning

confidence: 99%

“…However, it is difficult to identify these impairments of CCFS using cognitive tests (Kawatani et al, 2011). Several studies have revealed that performance is reduced in attentional control tasks in CCFS patients (Tomoda et al, 2007; Haig-Ferguson et al, 2009; Kawatani et al, 2011). In this review, we discuss the neural mechanisms of cognitive impairments in CCFS from the standpoint of performance on cognitive tasks and neurophysiological responsiveness such as event-related potentials (ERP) of electroencephalogram and activations and neural circuits of brain regions using functional magnetic resonance imaging (fMRI).…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive impairment in childhood chronic fatigue syndrome

Mizuno¹,

Watanabe²

2013

Front. Physiol.

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Neurocognitive impairment is a feature of childhood chronic fatigue syndrome (CCFS). Several studies have demonstrated reduced attention control in CCFS patients in switching and divided attention tasks. In students, the extent of deterioration in task performance depends on the level of fatigue. Poor performance in switching and divided attention is common in both fatigued students and CCFS patients. Additionally, attentional functions show dramatic development from childhood to adolescence, suggesting that abnormal development of switching and divided attention may be induced by chronic fatigue. The brain structures associated with attentional control are situated in the frontal and parietal cortices, which are the last to mature, suggesting that severe fatigue in CCFS patients and students may inhibit normal structural and functional development in these regions. A combination of treatment with cognitive behavioral therapy and antidepressant medication is effective to improve attentional control processing in CCFS patients. Studies identifying the features of neurocognitive impairment in CCFS have improved our current understanding of the neurophysiological mechanisms of CCFS.

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“…The higher the athletic ability, the stronger the ability to use the energy in body [6]. On the reverse, the lower the athletic ability, the weaker ability of the energy processing while movement [7].…”

Section: Discussionmentioning

confidence: 99%

The Results of Physical Fitness Test for Chinese College Students of Different Ethnic Groups Majoring in Physical Education

Guo¹,

Song²,

Chi³

2018

Proceedings of the 2018 4th Annual International Conference on Modern Education and Social Science (MESS 2018)

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Abstract:Objective: To illustrate the differences of body composition and athletic ability of ethnic minorities students and Han students. Methods: test the body composition and athletic ability of 112 Han and minorities college students in Shaanxi Normal University. Results: The percentage of body fat in male minority students is significantly lower than that in Han (P<0.05). The statistic of female minority students compared with the Han had no statistical significance (P>0.05). Conclusion: There are some difference in physical fitness between male minority college students and male Han college students.

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Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome – A 6-month follow-up study

Cited by 35 publications

References 50 publications

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Neurocognitive impairment in childhood chronic fatigue syndrome

The Results of Physical Fitness Test for Chinese College Students of Different Ethnic Groups Majoring in Physical Education

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