Cognitive Dysfunction and Physical Disability Are Associated with Mortality in Extremely Elderly Patients

Hoshide, Satoshi; Ishikawa, Joji; Eguchi, Kazuo; Oowada, Tsuneo; Shimada, Kazuyuki

doi:10.1291/hypres.31.1331

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…Our results of increased mortality for those with poor TUG performance correspond well with results from other similar studies [51, 52, 55–58]. However, some of these studies did not include both genders [51, 52].…”

Section: Discussionsupporting

confidence: 91%

Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromsø study

Bergland

Jørgensen

Emaus

et al. 2017

BMC Health Serv Res

117

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BackgroundDisability in older adults is associated with loss of independence, institutionalization, and death. The aim of this study was to study the association between the Timed Up and Go (TUG) test and all-cause mortality in a population-based sample of older men and women.MethodsOur study population was home dwellers aged 65 and above, who participated in the fifth wave of the Tromsø study. This study included the TUG test and a range of lifestyle and mortality predictors. Participants were linked to the Cause of Death Registry and followed up for mortality for a maximum of 11.8 years. Cox regression was used to investigate the association between TUG and total mortality.ResultsMean TUG score was 12.6 s, and men performed better than women. The oldest participants had poorer TUG score compared to younger participants, increasing 0.25 s per year. There was a significant association between TUG and all-cause mortality, and the association was equally strong in men and women. Across the TUG-score categories, from quickest fifth to slowest fifth, the mortality increased in a step-wise fashion. Compared to the quickest fifth, the slowest fifth had hazard ratio (HR) of 1.79 (95% confidence interval (CI) 1.33, 2.42) in a model adjusted for age and gender. For each standard deviation TUG-score the increase in HR was 1.23 (95% CI 1.14, 1.33). The association between the TUG score and mortality remained significant after adjusting for self-reported health, body mass index, smoking and education.ConclusionsA significant association between the TUG score and mortality was observed in both men and women. Identifying older people with poor TUG may aid in identifying those at risk and thus targeted interventions may be applied.

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Section: Discussionsupporting

confidence: 91%

Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromsø study

Bergland

Jørgensen

Emaus

et al. 2017

BMC Health Serv Res

117

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“… found a strong association in postmenopausal women and Hoshide et al . reported a correlation between TUG and cardiovascular mortality in the very old subjects at least 80 years of age. Lastly, according to Davis et al .…”

Section: Discussionmentioning

confidence: 95%

Physical function measurements predict mortality in ambulatory older men

Buyser

Petrovic

Taes

et al. 2013

Eur J Clin Investigation

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“…The simple visual WM test used in this study easily evaluated WM function even in elderly patients ≥80 years. As we also reported regarding this test (for which the association between the decrease in cognitive function and mortality was established), we observed that cognitive dysfunction assessed by this same simple visual WM test was an independent risk factor for total death and cardiovascular death in elderly ≥80 years, which indicates that this simple test would be an effective method for evaluating both the cognitive function and mortality risk in the very elderly. Further studies are needed to validate the clinical implication of this simple test.…”

Section: Discussionmentioning

confidence: 99%

Exaggerated blood pressure variability is associated with memory impairment in very elderly patients

Fujiwara

Hoshide

Kanegae

et al. 2018

J of Clinical Hypertension

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We investigated the association between working memory (WM) impairment and blood pressure variability (BPV) in very elderly patients. Japanese outpatients ≥80 years who engaged in normal activities of daily living were the study cohort. WM function was evaluated by a simple visual WM test consisting of 3 figures. We considered the number of figures recalled by the patient his/her test score. We defined the patients with a score of 0 or 1 as those with WM impairment and those with scores of 2 or 3 as those without. To investigate the relative risk of WM impairment, we evaluated each patient's 24 hour ambulatory systolic blood pressure (SBP) and its weighted standard deviation (SD ), office SBP, and the visit-to-visit SD during the 1 year period from the patient's enrollment. A total of 66 patients (mean 84 ± 3.6 years) showed WM impairment, and 431 patients (mean 83 ± 3.1 years) showed no WM impairment. There were no significant differences in 24 hour ambulatory SBP or office SBP between these two groups. However, the WM impairment patients showed significantly higher weighted SD and visit-to-visit SD values compared to the no-impairment group even after adjusting for age. Among these ≥80-year-old patients, those with the highest quartile of both weighted SD (≥21.4 mm Hg) and visit-to-visit SD (≥14.5 mm Hg) showed the highest relative risk (odds ratio 3.52, 95% confidence interval 1.42-8.72) for WM impairment. Exaggerated blood pressure variability parameters were significantly associated with working memory impairment in very elderly individuals.

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Cognitive Dysfunction and Physical Disability Are Associated with Mortality in Extremely Elderly Patients

Cited by 11 publications

References 35 publications

Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromsø study

Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromsø study

Physical function measurements predict mortality in ambulatory older men

Exaggerated blood pressure variability is associated with memory impairment in very elderly patients

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