Cognitive dysfunction and work productivity in major depressive disorder

Clark, Marci; DiBenedetti, Dana; Pérez, Vanessa

doi:10.1080/14737167.2016.1195688

Cited by 92 publications

(45 citation statements)

References 45 publications

(96 reference statements)

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“…[14][15][16] Such symptoms have been shown to negatively impact both clinical and functional outcomes in patients with MDD, including HRQoL and work productivity. [17][18][19][20][21][22][23][24][25][26][27][28] However, data are lacking concerning the impact of cognitive symptoms on HRQoL and work productivity in Chinese patients with MDD. The Prospective Research Observation to Assess Cognition in Treated patients with MDD (PROACT) study was undertaken to evaluate the prevalence and course of cognitive symptoms in Chinese patients initiating new antidepressant treatment in a real-world setting.…”

Section: Introductionmentioning

confidence: 99%

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

Wang¹,

Tan²,

Ren³

et al. 2020

NDT

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Purpose: This post hoc analysis was undertaken to further explore the association of cognitive symptoms with health-related quality of life (HRQoL) and work productivity at the time of treatment initiation in Chinese patients with major depressive disorder (MDD) in the Prospective Research Observation to Assess Cognition in Treated patients with MDD (PROACT) study. Patients and Methods: This was an epidemiological, non-interventional, prospective cohort study in adult outpatients with moderate-to-severe MDD initiating antidepressant monotherapy (first or second line). Crude and adjusted analyses of covariance were performed to assess the association of perceived cognitive symptoms (20-item Perceived Deficits Questionnaire-Depression [PDQ-D] total score) or observed cognitive performance (Digit Symbol Substitution Test [DSST] score) with HRQoL (EuroQoL 5-Dimensions Questionnaire index) and work productivity (Work Productivity and Activity Impairment [WPAI] or Sheehan Disability Scale [SDS] absenteeism and presenteeism scores). Adjusted analyses included depression severity, age, sex, residential area (urban/rural), and educational level. Results: Of 1008 patients enrolled in the PROACT study, 986 were included in this analysis. Severity of perceived cognitive symptoms (ie, higher PDQ-D total score) was significantly associated with worse HRQoL (P<0.001) and higher levels of absenteeism (P=0.020 for the WPAI and P=0.002 for the SDS) and presenteeism (P<0.001 for both scales). The association of perceived cognitive symptoms with HRQoL and presenteeism was independent of depression severity. The association between observed cognitive performance (DSST score) and HRQoL was less robust. No association was seen between observed cognitive performance and levels of absenteeism or presenteeism assessed by either scale. Conclusion: Results of this real-world study illustrate the impact of cognitive symptoms on HRQoL and work productivity in Chinese patients with MDD, and highlight the importance of assessing and targeting cognitive symptoms in order to improve functional outcomes when treating patients with MDD.

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Section: Introductionmentioning

confidence: 99%

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

Wang¹,

Tan²,

Ren³

et al. 2020

NDT

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“…20,21 The clinical relevance of cognitive symptoms, including disturbances in attention, memory, processing speed, and executive functioning, and their role in work-related disability is well documented in MDD. 16,[22][23][24][25][26][27] Compared with depression severity, cognitive symptoms have been reported to account for greater impairment in workplace functioning in patients with MDD. 28 Treatment of cognitive symptoms may hold the key to achieving functional recovery in MDD; however, the relationship between cognitive symptoms and functional impairment in MDD is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Long-term functioning outcomes are predicted by cognitive symptoms in working patients with major depressive disorder treated with vortioxetine: results from the AtWoRC study

Chokka

Bougie²,

Proulx³

et al. 2019

CNS Spectr.

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ObjectiveAtWoRC (Assessment in Work productivity and the Relationship with Cognitive symptoms) was an interventional, open-label, Canadian study (NCT02332954) designed to assess the association between cognitive symptoms and workplace productivity in working patients with major depressive disorder (MDD) receiving vortioxetine.MethodsEligible patients with MDD received vortioxetine (10–20 mg/day) and were assessed over 52 weeks at visits emulating a real-life setting (n = 199). Partial correlation between changes in patient-reported cognitive symptoms (20-item Perceived Deficits Questionnaire–Depression; PDQ-D-20) and workplace productivity (Work Limitations Questionnaire; WLQ) was assessed at 12 and 52 weeks. Additional assessments included depression severity, cognitive performance, and patient-reported functioning. Structural equations model (SEM) analyses assessed causal relationships between changes in measures of cognition and functioning over time, adjusted for improvements in depressive symptoms.ResultsStatistically significant improvements in all outcomes from baseline to week 52 were seen in the overall population and both subgroups (first treatment and switch). Response and remission rates were 77% and 56%, respectively. Improvements in PDQ-D-20 and WLQ productivity loss scores at weeks 12 and 52 were significantly correlated. SEM analyses found patient-rated cognitive symptoms (PDQ-D-20) at weeks 12 and 26 were significantly predictive (p < 0.05) of patient-reported functioning (Sheehan Disability Scale) at the subsequent visit. Depression severity and objectively measured cognitive performance did not significantly predict functional outcomes at any timepoint.ConclusionThese results demonstrate the long-term benefits of vortioxetine treatment in working patients with MDD and emphasize the strong association between cognitive symptoms and functioning in a real-world setting.

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“…In this sense, there are several studies describing the association between cognitive deficits and work performance (Birnbaum et al, 2010;McIntyre et al, 2015). In clinical populations, such as patients with major depressive disorder, cognitive impairments in the domains of executive functioning influence work productivity (Clark, DiBenedetti, & Perez, 2016). Executive functions are higher-order cognitive processes, which form a construct composed of multiple interrelated skills that serve goal-directed behaviour (Miranda, Franchetto Sierra, et al, 2019).…”

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confidence: 99%

Examining the relationship between engagement and perceived stress-related cognitive complaints in the argentinian working population

et al. 2020

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Stress has a negative impact on cognitive functioning and occupational well-being. The aim of this study was to assess the relationship among perceived stress, cognitive complaints and work engagement in public employees from Córdoba, Argentina. In this cross-sectional study, self-report questionnaires were administered to 240 participants. Spanish versions of the following instruments were used: Perceived Stress Scale (PSS), Utrecht Work Engagement Scale (UWES), Memory Failures in Everyday (MFE), Executive Complaint Questionnaire (ECQ). Statistical analysis included ANOVA, path analysis, and multiple logistic regression. Stressed workers showed lower work engagement and more cognitive complaints, even after adjusting for demographic variables. Negative associations were also observed between work engagement and cognitive complaints, suggesting that cognitive difficulties are related to engagement. Given the relation among stress, cognition, and work engagement, it is important to consider these factors to foster workers’ health and work productivity.

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Cognitive dysfunction and work productivity in major depressive disorder

Cited by 92 publications

References 45 publications

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

Long-term functioning outcomes are predicted by cognitive symptoms in working patients with major depressive disorder treated with vortioxetine: results from the AtWoRC study

Examining the relationship between engagement and perceived stress-related cognitive complaints in the argentinian working population

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