Cognitive dysfunction associated with pain and quality of life in chronic rhinosinusitis

Tarasidis, George S.; DeConde, Adam S.; Mace, Jess C.; Ashby, Shaelene; Smith, Timothy L.; Orlandi, Richard R.; Alt, Jeremiah A.

doi:10.1002/alr.21578

Cited by 37 publications

(32 citation statements)

References 31 publications

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“…This study suggests that inflammation is the underlying mechanism of sleep disturbance in CRS patients. This notion is supported by other studies that showed an association between inflammatory diseases like IBD [18] or rheumatoid arthritis [15] and poor sleep.…”

Section: Mechanism Of Sleep Disruption In Crssupporting

confidence: 81%

“…They found a significant reduction in one domain of cognitive function, simple reaction time, in CRS patients compared with healthy controls [14]. Tarasidis et al [15] found a similar mean CFQ score of 40.53 ± 18.14 in 70 CRS patients and a significant but weak correlation between cognitive function and pain scores in these cases. In that study, there were no healthy control subjects for comparison.…”

Section: Importance and Relevance Of Sleep Disruption In Crsmentioning

confidence: 99%

“…Sleep disruption in CRS causes a significant decline in QOL [9] and is linked to poor functional outcomes such as impaired cognitive function [14] and depression [9,14]. These outcomes undoubtedly contribute to the reported poor QOL [15] in CRS. Sleep disturbance is also a common complaint among patients with other inflammatory diseases of the upper airways such as allergic rhinitis (AR) [16,17], which is indicative of a link of sleep disturbance to inflammation and/or blockage of the upper airways.…”

Section: Introductionmentioning

confidence: 99%

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Sleep disruption in chronic rhinosinusitis

Mahdavinia

Schleimer

Keshavarzian

2017

Expert Review of Anti-infective Therapy

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Introduction Chronic rhinosinusitis (CRS) is a common disease of the upper airways and paranasal sinuses with a marked decline in quality of life (QOL). CRS patients suffer from sleep disruption at a significantly higher proportion (60 to 75%) than in the general population (8–18%). Sleep disruption in CRS causes decreased QOL and is linked to poor functional outcomes such as impaired cognitive function and depression. Areas covered A systematic PubMed/Medline search was done to assess the results of studies that have investigated sleep and sleep disturbances in CRS. Expert commentary These studies reported sleep disruption in most CRS patients. The main risk factors for sleep disruption in CRS include allergic rhinitis, smoking, and high SNOT-22 total scores. The literature is inconsistent with regard to the prevalence of sleep-related disordered breathing (e.g. obstructive sleep apnea) in CRS patients. Although nasal obstruction is linked to sleep disruption, the extent of sleep disruption in CRS seems to expand beyond that expected from physical blockage of the upper airways alone. Despite the high prevalence of sleep disruption in CRS, and its detrimental effects on QOL, the literature contains a paucity of studies that have investigated the mechanisms underlying this major problem in CRS.

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Section: Mechanism Of Sleep Disruption In Crssupporting

confidence: 81%

Section: Importance and Relevance Of Sleep Disruption In Crsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep disruption in chronic rhinosinusitis

Mahdavinia

Schleimer

Keshavarzian

2017

Expert Review of Anti-infective Therapy

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“…In addition, we used the pain-specific metric (BPI-SF) and the SNOT-22 questionnaires, had different treatment regimes, and our sample size was smaller, all of which can influence the end result. Chronic rhinosinusitis symptoms can have a negative impact on quality of life [47], especially in interference with sleep [65]. Lack of sleep is correlated with depression in CRS patients [3].…”

Section: Discussionmentioning

confidence: 99%

Multimodal Frequency Treatment for Facial Pain Caused by Chronic Rhinosinusitis: A Pilot Study

et al. 2017

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Chronic rhinosinusitis (CRS) is a common disease that affects over 200 million patients worldwide. CRS often presents with facial pain, which is considered an important criterion for the diagnosis of CRS. A single-arm clinical study was designed to test the effect of simultaneous high (1 MHz) and low frequencies (70-80 Hz) on facial pain in 14 CRS patients at the Sarah Bush Lincoln Health Center, Mattoon, IL, USA. We used two quality of life (QOL) instruments to test the effect of multimodal frequencies on patients suffering from CRS: the Brief Pain Inventory Short Form (BPI-SF), and the Sino-Nasal Outcome Test (SNOT-22). Mean BPI-SF severity scores improved by 0.80 points (Wilcoxon rank sum test p < 0.01) in all 14 patients. In patients with baseline facial pain (n = 9), the scores improved by an average of 1.5 (p < 0.01) points in the pain severity domain and by 1.4 points in the pain interference domain. Additionally, the mean improvement in SNOT-22 scores was 14.11 (p < 0.05), which is above the minimal clinically-important difference (MCID) of nine points. Our pilot study indicates that multimodal vibration frequencies applied over the facial sinuses reduce pain, possibly through the reduction of the inflammatory response and modulation of the pain receptors. This study suggests the possibility that combining different frequencies could have an enhanced effect on reducing CRS-related facial pain.

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“…Current treatments for CRS are aimed at reducing inflammation and its associated local effects with improvements in QOL. Recent investigations suggest that the health impacts of CRS extend beyond the sinuses and can impact basic functions including sleep, cognition, and mood . It has been hypothesized that these extra‐rhinologic symptoms are due to a sophisticated and intertwined communication between the central nervous system and the immune system .…”

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confidence: 99%

Mortality risk in patients with chronic rhinosinusitis and its association to asthma

Alt

Thomas

Curtin

et al. 2017

Int Forum Allergy Rhinol

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Background Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory condition, with significant effects on morbidity and quality of life. Given other chronic inflammatory conditions have been associated with increased mortality risk, we sought to evaluate the relationship between mortality and CRS including the influence of asthma. Our objective was to determine if CRS, with or without asthma, is associated with altered risk of mortality. Methods Using a statewide population database, we retrospectively identified 27,005 patients diagnosed with CRS between 1996 and 2012, and 134,440 unaffected controls matched 5:1 on birth year and sex. Risk of mortality was determined from Cox models and Kaplan-Meier curves were used to compare survival. Results A significant interaction between CRS and asthma status was observed in which CRS appeared to confer a protective effect in asthma patients. Asthma, when present, increased mortality in CRS-negative controls (P-interaction <0.0001). Independent of asthma status, CRS patients exhibited a decreased mortality risk (HR=0.80, 95%CI 0.74-0.85) compared to controls. However, in patients diagnosed at or before the median age of CRS onset (42y) independent of asthma status, survival was not improved (HR=0.98, 95%CI 0.81-1.18). Risk of mortality was greater in CRS with nasal polyps (n=1643) compared to 25,362 polyp-negative CRS patients (HR=1.38, 95%CI 1.09–1.77). Conclusions CRS was associated with lower risk of mortality compared to controls, and appeared to mitigate increased mortality from asthma. We posit that better survival conferred by CRS may be secondary to treatment. However, the etiology of this relationship and the effect of CRS treatment on mortality are unknown.

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Cognitive dysfunction associated with pain and quality of life in chronic rhinosinusitis

Cited by 37 publications

References 31 publications

Sleep disruption in chronic rhinosinusitis

Sleep disruption in chronic rhinosinusitis

Multimodal Frequency Treatment for Facial Pain Caused by Chronic Rhinosinusitis: A Pilot Study

Mortality risk in patients with chronic rhinosinusitis and its association to asthma

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