Cognitive effects of acute restraint stress in male albino rats and the impact of pretreatment with quetiapine versus ghrelin

Amin, Shaimaa Nasr; Gamal, Sarah; Esmail, Reham Shehab El Nemr; Aziz, Tarek; Rashed, Laila Ahmed

doi:10.1142/s0219635214500253

Cited by 13 publications

(6 citation statements)

References 84 publications

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“…We sought to investigate the association between prenatal stress and anxiety-related behaviors in another popular paradigm. While the Open Field is regularly used for anxiety assessments (Amin et al, 2014), the data collected after the test vary from one study to another. Some research teams examined the crossover, rearing, head poke and corner activities (Pohorecky & Roberts, 1991) while others preferred to take into account the percent (Hougaard et al, 2005) or the total time spent in the center (Laloux et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

Said¹,

Lakehayli²,

Battas³

et al. 2015

J. Integr. Neurosci.

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We assess the anxiety-like behavior in the open field and elevated plus maze tests and measure the nociceptive response in the tail flick test following prenatal stress exposure in adult male and female Wistar rats. In both behavioral anxiety tests, prenatal stress increased the anxiety-like behavior in male PS rats, but not in females suggesting a strong sex-dependent anxiogenic effect. The tail flick results showed a hypersensitivity to pain in male and female PS rats with a subtle gender difference. These findings suggest that prenatal stress is an important risk factor for multiple mental disorders.

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Section: Methodsmentioning

confidence: 99%

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

Said¹,

Lakehayli²,

Battas³

et al. 2015

J. Integr. Neurosci.

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“…The hippocampus is necessary for the formation of declarative memory in humans, spatial memory in rodents, memory consolidation, reconsolidation, long-term memory persistence, novelty detection, habituation, and long-term potentiation [2]. ARS adversely affects the hippocampus both structurally and functionally [3,4].…”

Section: Introductionmentioning

confidence: 99%

Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone

et al. 2020

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Acute restraint stress (ARS) is an unavoidable stress situation and may be encountered in different clinical situations. The aim of the current study was to investigate the effects of ARS on the hippocampus and cerebellum, assess the impact of these effects on the behavior and cognitive function, and determine whether pretreatment with ceftriaxone would attenuate the damages produced by ARS on the hippocampus and cerebellum. Four groups of male mice were included in this study: The control group, ARS group, ceftriaxone group, and ARS + ceftriaxone group. Tail suspension test, Y-maze task, and open field tests were used to assess depression, working spatial memory, and anxiety. The biochemical analyses included measurements of serum cortisol, tumor necrotic factor (TNF), interleukin-6, hippocampal expression of bone morphogenetic protein 9 (BMP9), lysosomal-associated membrane protein 1 (LAMP1), glutamate transporter 1 (GLT1), heat shock protein 90, cerebellar expression of S100 protein, glutamic acid decarboxylase (GAD), and carbon anhydrase. Histopathological examination of the brain sections was conducted on the hippocampus and cerebellum by hematoxylin and eosin stains in addition to ultrastructure evaluation using electron microscopy. Our results suggested that ceftriaxone had neuroprotective properties by attenuating the effects of ARS on the hippocampus and cerebellum in mice. This effect was demonstrated by the improvement in the cognitive and behavioral tests as well as by the preservation of the hippocampal and cerebellar architecture.

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“…For example, it has been reported that QUE transiently disrupts avoidance behavior in a conditioned avoidance response task because it only transiently blocks D 2 receptors [44]. It has also been reported that QUE decreases object recognition deficits in a rat model of malformations of cortical development [26], stress-induced spatial working memory impairment [45], and reverses methamphetamine-induced cognitive deficits [46]. The benefits attributed to QUE could be due, in part to, to increased levels of DA in the frontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma

Weeks

Carlson

Radabaugh

et al. 2018

Behavioural Brain Research

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Traumatic brain injury (TBI)-induced agitation and aggression pose major obstacles to clinicians in the acute hospital and rehabilitation settings. Thus, management of these symptoms is crucial. Antipsychotic drugs (APDs) are a common treatment approach for alleviating these symptoms. However, previous preclinical TBI studies have indicated that daily and chronic administration of these drugs (e.g., haloperidol; HAL) can exacerbate cognitive and motor deficits. Quetiapine (QUE) is an atypical APD that differs from many typical APDs, such as HAL, in its relatively rapid dissociation from the D receptor. The goal of this study was to test the hypotheses that intermittent HAL and QUE would not hinder recovery of cognitive and motor function following TBI and that daily QUE would also not impair functional recovery, which would be in contrast to HAL. Seventy anesthetized male rats received either a controlled cortical impact or sham injury and were then randomly assigned to TBI and sham groups receiving HAL (0.5mg/kg) or QUE (10mg/kg) intraperitoneally once per day or once every other day and compared to each other and vehicle (VEH) controls. Motor function was assessed by beam balance/walk tests on post-operative days 1-5 and cognitive function was evaluated with a Morris water maze task on days 14-19. No differences were revealed among the sham groups in any task, and hence the data were pooled. No overall differences were detected among the TBI groups, regardless of treatment or administration paradigm [p>0.05], but all were impaired vs. SHAM controls [p<0.05]. The SHAM controls also performed significantly better in the cognitive test vs. all TBI groups [p<0.05]. Moreover, the TBI+continuous HAL group performed worse than the TBI+continuous VEH, TBI+continuous QUE, and TBI+intermittent QUE groups [p<0.05], which did not differ from one another. Overall, the data suggest that QUE does not exacerbate TBI-induced cognitive and motor deficits, which supports the hypothesis. QUE may prove useful as an alternative APD treatment for management of agitation and aggression after clinical TBI. HAL may also be safe, but only if used sparingly.

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Cognitive effects of acute restraint stress in male albino rats and the impact of pretreatment with quetiapine versus ghrelin

Cited by 13 publications

References 84 publications

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone

Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma

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