Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up

Lee, Ho‐Won; Jung, Daewoong; Suh, Chung-Kyu; Kwon, Soonhak; Park, Sung-Pa

doi:10.1016/j.yebeh.2006.03.006

Cited by 78 publications

(63 citation statements)

References 20 publications

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“…Some previously documented studies support our results where topiramate administration in epileptic patients has impaired memory. [28][29][30] The results in this study showed similar results to those studies.…”

Section: Topiramate Versus Other Groups In This Studysupporting

confidence: 88%

A comparative study of effect of phenytoin, topiramate, and zonisamide in learning and memory of albino rats

Loc

Chakraborty

Kumar

et al. 2017

Int J Basic Clin Pharmacol

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Background: Epilepsy is one of the non-communicable neurologic diseases leading to significant morbidity and mortality. Complaints of impaired learning and memory are common in patients of epilepsy. Antiepileptic drugs (AEDs) may further enhance this impairment. So, the present study was carried out on albino rats to evaluate the effect of AEDs on learning and memory.Methods: Albino rats of about 150 -200 gm of either sex were treated with drugs for 15 days and assessed for effect on learning behavior and again treated for next 15 days after which they were assessed for retention behavior on Morris water maze and Elevated plus maze. The data was statistically analyzed by ANOVA and Tukey HSD.Results: Phenytoin and topiramate causes significant delay in learning and memory whereas zonisamide doesn’t causes significant delay in learning and memory.Conclusions: Impairment in learning and memory occurs in treatment with phenytoin and topiramate but not with zonisamide in low therapeutic doses.

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Section: Topiramate Versus Other Groups In This Studysupporting

confidence: 88%

A comparative study of effect of phenytoin, topiramate, and zonisamide in learning and memory of albino rats

Loc

Chakraborty

Kumar

et al. 2017

Int J Basic Clin Pharmacol

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show abstract

“…No studies specifically address the cognitive effects of topiramate in the population with TBI; however, topiramate is known to cause impairment of language, attention, memory, and executive function in patients with epilepsy and intellectual impairment [87]. In a study of chronic administration of low-dose topiramate for epilepsy, 44 percent of 47 patients demonstrated cognitive deficits [88]. Behavioral difficulties such as psychomotor agitation, aggressiveness, and psychoses have also been reported after topiramate therapy [89].…”

Section: Antiepileptic Agentsmentioning

confidence: 99%

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

Chew

Zafonte²

2009

JRRD

163

103

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Abstract-Pharmacological management of neurobehavioral disorders following traumatic brain injury (TBI) is common practice. However, the evidence available to guide this practice remains sparse. This review summarizes, in brief, the state of knowledge, organized via a time continuum from injury as well as by symptom complex. The areas of neuroprotection, hypoarousal, attention and memory deficits, aggression, agitation, depression, and mania are reviewed. The literature was searched with PubMed on the terms "traumatic brain injury" or "brain injury" with "pharmacology" (and the symptoms according to which this review is arranged). Additional searches were conducted with the specific symptoms as search terms, crossed with the therapeutic agents or drug classes discussed. Where a paucity of prospective data exists, case reports and retrospective studies are included. Studies to date have yielded minimal positive evidence for enhancing function, memory, and behavior after TBI. No single agent likely will become sentinel in the recovery process, and combination therapy in the acute and postacute settings are required. A need exists to further define the role of psychopharmacology in postacute TBI medicine and the specific characteristics of subpopulations who might benefit.

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“…Whereas the use of phenytoin in one study was associated with cognitive impairment, valproic acid and carbamazepine, when used as seizure prophylaxis, have not been shown to be associated with cognitive impairment [25]- [27]. Topiramate in patients with epilepsy and intellectual impairment was reported to cause language, attention, memory and executive function difficulties, and therefore practitioners may choose to avoid using this medication in the acute and post-acute TBI population [28] [29]. Gabapentin led to heightened anxiety and psychomotor agitation in 2 patients with traumatic brain injury [30].…”

Section: Aeds For Agitation Following Acute Traumatic Brain Injurymentioning

confidence: 99%

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

Nejad

Chuang²,

Hirschberg³

et al. 2014

IJCM

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Antiepileptic drugs (AEDs), have demonstrated efficacy treating a number of acute conditions, encompassing a broad range of symptoms and syndromes, in addition to being first-line treatment for epilepsy. Clinically, since their inception, AEDs have been used off-label for acute and chronic medical conditions, both as primary and as adjuvant therapies. In this review, we describe the observed clinical effectiveness of AEDs across a set of commonly encountered acute conditions in the general hospital: traumatic brain injury, pain, alcohol withdrawal. In describing the individual benefits and usages of specific agents, the applicability of these agents to other common neuropsychiatric conditions may be further explored.

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Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up

Cited by 78 publications

References 20 publications

A comparative study of effect of phenytoin, topiramate, and zonisamide in learning and memory of albino rats

A comparative study of effect of phenytoin, topiramate, and zonisamide in learning and memory of albino rats

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

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