Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

Burns, Allison M.; Gräff, Johannes

doi:10.1016/j.conb.2020.08.011

Cited by 46 publications

(33 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stress management techniques include the science of meditation as well [6,7]. This is due to quantum physics [8][9][10], metaphysics [9], neuroplasticity [11] and psychoneuroimmunology [12] appearing in meditation. The essence of the science field is that objective perception is replaced by subjective perception (https://www.youtube.com/watch?v=Tpuwm7cmp1M).…”

Section: Introductionmentioning

confidence: 99%

The Role of Nutrition in Preventive Medicine: The Place of Street Food in International Gastronomy and Health Development

Pal,

Molnár

2021

JNFP

View full text Add to dashboard Cite

Nowadays, due to the pandemic, preventive medicine also plays a prominent role in medical science. In addition to physical activity or techniques used in alternative medicine (acupuncture, forms of massage, yogic exercise etc.), the science of meditation has become the part of preventive medicine thanks to quantum physics, epigenetics, metaphysics, neuroplasticity, and psychoneuroimmunology. Firstly, we examined the role of nutrition science in preventive medicine in the manuscript. Therefore, we present foods that reinforce the street food philosophy while being healthy and promoting health improvement. Furthermore, these foods can be used as part of various diets. The manuscript contributes to the health promoting effect of nutrition science and gastronomy and its role in preventive medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Nutrition in Preventive Medicine: The Place of Street Food in International Gastronomy and Health Development

Pal,

Molnár

2021

JNFP

View full text Add to dashboard Cite

show abstract

“…It thus amplifies the induction of transcriptional programs downstream of learning-related circuit activity and neuronal signaling, thereby boosting memory formation (Gräff and Tsai, 2013). Follow-up studies have corroborated the link between histone acetylation, stimulus-dependent gene expression, and different phases of memory, thus supporting a mechanism whereby HDACi-induced epigenetic priming may ameliorate memory (Burns and Gräff, 2020). In addition to histone acetylation, many other neuro-epigenetic processes have emerged with critical roles for activity-dependent transcription and synaptic plasticity, highlighting the importance of epigenome regulation in information storage and normal brain function (for review, see Campbell and Wood, 2019).…”

Section: Neuronal Activity Shapes the Epigenomementioning

confidence: 90%

From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health

et al. 2021

View full text Add to dashboard Cite

A central goal of neuroscience research is to understand how experiences modify brain circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit activity engages gene regulatory mechanisms within each cell. This activity-dependent gene expression is governed, in part, by epigenetic processes that can produce persistent changes in both neural circuits and the epigenome itself. The complex interplay between circuit activity and neuronal gene regulation is vital to learning and memory, and, when disrupted, is linked to debilitating psychiatric conditions, such as substance use disorder. To develop clinical treatments, it is paramount to advance our understanding of how neural circuits and the epigenome cooperate to produce behavioral adaptation. Here, we discuss how new genetic tools, used to manipulate neural circuits and chromatin, have enabled the discovery of epigenetic processes that bring about long-lasting changes in behavior relevant to mental health and disease.

show abstract

“…They might constitute a new strategy for pharmacological interventions against cognitive impairments by improving learning capacity, activating learning genes and mediating "cognitive epigenetic priming" [78]. "Cognitive epigenetic priming" is a theory that aims to explain the potential of histone acetylation to promote memory by facilitating the expression of neuroplasticity-related genes [78]. This is of special relevance, since cognitive impairment seems to be closely related with frailty, as we described above.…”

Section: Histone Ptms and Histone Variants As Frailty Biomarkersmentioning

confidence: 96%

“…Accordingly, several histone deacetylase inhibitors (HDACis) have proven successful in rescuing cognitive deficits in animal models of neurodegeneration and cognitive decline such as Alzheimer's disease [77]. They might constitute a new strategy for pharmacological interventions against cognitive impairments by improving learning capacity, activating learning genes and mediating "cognitive epigenetic priming" [78]. "Cognitive epigenetic priming" is a theory that aims to explain the potential of histone acetylation to promote memory by facilitating the expression of neuroplasticity-related genes [78].…”

Section: Histone Ptms and Histone Variants As Frailty Biomarkersmentioning

confidence: 99%

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

García-Giménez

Mena-Mollá

Tarazona-Santabalbina

et al. 2021

IJERPH

View full text Add to dashboard Cite

The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregulation of multiple physiologic systems leading to adverse health outcomes for individuals of the same chronological age. A key approach to overcome the challenges of frailty is the development of biomarkers to improve early diagnostic accuracy and to predict trajectories in older individuals. The identification of epigenetic biomarkers of frailty could provide important support for the clinical diagnosis of frailty, or more specifically, to the evaluation of its associated risks. Interventional studies aimed at delaying the onset of frailty and the functional alterations associated with it, would also undoubtedly benefit from the identification of frailty biomarkers. Specific to the article yet reasonably common within the subject discipline.

show abstract

Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

Cited by 46 publications

References 68 publications

The Role of Nutrition in Preventive Medicine: The Place of Street Food in International Gastronomy and Health Development

The Role of Nutrition in Preventive Medicine: The Place of Street Food in International Gastronomy and Health Development

From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

Contact Info

Product

Resources

About