Cognitive Event-Related Potentials in Multiple Sclerosis

Newton, Mark R.; Barrett, Geoff; Callanan, Margie; Towell, Anthony

doi:10.1093/brain/112.6.1637

Cited by 92 publications

(43 citation statements)

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“…Newton et al 14 found an incidence of 57% of cognitive potential alterations that included delays in wave latencies and lack of its characteristic morphology. Dijk et al 15 did not find differences in event-related evoked potentials in a group of 30 patients with MS, with an incidence of 15.6% of wave peak absence of all the potentials assessed.…”

Section: Resultsmentioning

confidence: 99%

“…Newton et al 14 reported that event-related evoked potential generation would be, in part, dependant on white matter integrity, and mild degrees of cognitive dysfunction would not always be detected by intellectual capacity assessment tests, thus the possibility of objective tests, carried out by event-related evoked potentials become a useful tool in clinical practice.…”

Section: Resultsmentioning

confidence: 99%

“…MS patient assessment by means of long latency auditory evoked potentials 14 has shown alterations in wave latency and shape 15,16 , as its correlation with altered neuropsychological tests 17 .…”

Section: Introductionmentioning

confidence: 99%

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Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Santos

Munhoz

Peixoto³

et al. 2006

Rev. Bras. Otorrinolaringol.

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Mi smatch Negativity is a functional index of the supratemporal auditory cortex. Aim: The aim of the present study on Mismatch Negativity (MMN) in multiple sclerosis (MS) patients was to evaluate if the MMN can be correlated with cognitive deficits assessed by the Paced Auditory Addition Task -PASAT. Method: a clinical study in forty females and 20 males separated in two groups: control individuals and those with a definite diagnosis of MS underwent a duration and frequncy MMN. The MMN latencies and negative amplitudes obtained from the MS group were compared to the ones from the control group. The scores from the Paced Auditory Addition Task were correlated either with the presence or the absence of MMN. Results: MMN was found in 60% of the individuals with multiple sclerosis within the auditory stimulation protocol with varied durations, and in 45 % within the auditory stimulation protocol with frequency variations. There were no statistically significant differences in latencies and amplitudes when compared to controls. We found a statistically significant correlation for the lack of MMN wave together with cognitive disorder asserted by the PASAT. Conclusions: The MMN correlated to the cognitive deficit assessed by the PASAT.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Santos

Munhoz

Peixoto³

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…[17][18][19] One study in which the N1 and P2 potentials were reportedly affected is that of Giesser et al, 20 but this was in demented as compared with non-demented patients. More recently, Hendler et al 21 found long latency AEPs to be abnormal only in conjunction with bilaterally abnormal short latency potentials.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological evidence for a defect in the processing of temporal sound patterns in multiple sclerosis

Jones

Sprague²,

Pato³

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Objectives: To assess the processing of spectrotemporal sound patterns in multiple sclerosis by using auditory evoked potentials (AEPs) to complex harmonic tones. Methods: 22 patients with definite multiple sclerosis but mild disability and no auditory complaints were compared with 15 normal controls. Short latency AEPs were recorded using standard methods. Long latency AEPs were recorded to synthesised musical instrument tones, at onset every two seconds, at abrupt frequency changes every two seconds, and at the end of a two second period of 16/s frequency changes. The subjects were inattentive but awake, reading irrelevant material. Results: Short latency AEPs were abnormal in only 4 of 22 patients, whereas long latency AEPs were abnormal to one or more stimuli in 17 of 22. No significant latency prolongation was seen in response to onset and infrequent frequency changes (P1, N1, P2) but the potentials at the end of 16/s frequency modulations, particularly the P2 peaking approximately 200 ms after the next expected change, were significantly delayed. Conclusion:The delayed responses appear to be a mild disorder in the processing of change in temporal sound patterns. The delay may be conceived of as extra time taken to compare the incoming sound with the contents of a temporally ordered sensory memory store (the long auditory store or echoic memory), which generates a response when the next expected frequency change fails to occur. The defect cannot be ascribed to lesions of the afferent pathways and so may be due to disseminated brain lesions visible or invisible on magnetic resonance imaging.A large proportion of patients with established multiple sclerosis (MS) have lesions of central auditory pathways, which can be shown by using short latency auditory evoked potentials (AEPs).1 Abnormalities are also often observed in long latency event related potentials (ERPs). These, however, cannot usually be ascribed to afferent pathway lesions but presumably to localised or diffuse lesions within the brain.2 Most patients in the advanced stages of MS exhibit some degree of cognitive impairment.3 Minor cognitive deficits have also been noted in the early stages, for example, in the performance of verbal memory and abstract reasoning tasks. 4 In a group of mildly affected MS patients whose clinical symptoms were entirely attributable to disease of the spinal cord, the P3 component of the ERP was yet found to be significantly altered as compared with control subjects during performance of auditory and visual working memory tasks. 5 An earlier ERP component reflecting short term memory processes is the mismatch negativity. 6 This potential is elicited automatically (that is, not requiring the conscious attention of the subject) by discrete sounds that differ in some respect from the preceding sequence of sounds. The mismatch negativity appears to depend on retention of the sounds in a sensory memory store, the long auditory store or echoic memory, which decays over a period of a few seconds. 7 The chief distinction betwe...

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“…Os achados encontrados nesta pesquisa referentes à presença de alterações no P300 em indivíduos com EM, bem como ao tipo de alteração mais freqüentemente encontrada neste potencial, ou seja, atraso na latência da onda P300, são compatíveis com os obtidos por Newton et al (1989), Giesser et al (1992), Gil et al (1992), Dijk et al (1992) …”

Section: Parte II -Resultados Do Potencial Evocado Auditivo De Médiaunclassified

Potenciais evocados auditivos e esclerose múltipla

Oliveira

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Cognitive Event-Related Potentials in Multiple Sclerosis

Cited by 92 publications

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Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Electrophysiological evidence for a defect in the processing of temporal sound patterns in multiple sclerosis

Potenciais evocados auditivos e esclerose múltipla

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