Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study

Kong, Ling-lin; Xie, Wen; Dong, Zi-yan; Liu, Yue-ting; Zhao, Hui-Min; Fan, Jun-Yao; Qi, Xiao-jing; Li, Jie

doi:10.1186/s12877-024-04773-0

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…In this study, 92 community-dwelling older adults with cognitive frailty accounted for 18.5%. The result is higher than the prevalence of cognitive frailty reported in mainland China (8.9%) 36 and Japan (2.1%). 37 However, it is lower than older adults in Malaysia (39.6%) 38 and Spain (23.6%).…”

Section: Discussioncontrasting

confidence: 58%

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

Bai,

Chen,

Tian

et al. 2024

CIA

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Section: Discussioncontrasting

confidence: 58%

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

Bai,

Chen,

Tian

et al. 2024

CIA

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“…Depression, once merely categorized as an emotional disturbance, is now acknowledged as a complex disorder characterized by a spectrum of emotional, physical, and cognitive symptoms ( 4 , 5 ). Depression can lead to cognitive impairment, reflecting a significant impact on mental processing and functioning ( 6 , 7 ). Manifestations of depression include insomnia or hypersomnia, persistent fatigue, loss of appetite, and mood fluctuations, with severe cases posing a potential threat to life ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Current landscape of fecal microbiota transplantation in treating depression

Zhang,

Bi,

Zhang

et al. 2024

Front. Immunol.

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Depression, projected to be the predominant contributor to the global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication and psychotherapy often fall short, prompting the pursuit of alternative interventions. Recent research has highlighted the significant role of gut microbiota in mental health, influencing emotional and neural regulation. Fecal microbiota transplantation (FMT), the infusion of fecal matter from a healthy donor into the gut of a patient, emerges as a promising strategy to ameliorate depressive symptoms by restoring gut microbial balance. The microbial-gut-brain (MGB) axis represents a critical pathway through which to potentially rectify dysbiosis and modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals and reduce inflammatory markers, thereby alleviating depressive behaviors. Moreover, FMT has shown promise in clinical settings, improving gastrointestinal symptoms and overall quality of life in patients with depression. The review highlights the role of the gut-brain axis in depression and the need for further research to validate the long-term safety and efficacy of FMT, identify specific therapeutic microbial strains, and develop targeted microbial modulation strategies. Advancing our understanding of FMT could revolutionize depression treatment, shifting the paradigm toward microbiome-targeting therapies.

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Prevalence and risk factors of cognitive frailty in patients with cardiovascular disease: A hospital-based cross-sectional study

Guo,

Zhang,

Yang

et al. 2024

Medicine

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The prevalence of the cognitive frailty is increasing in China. Screening for this condition is crucial for its early detection, prevention, and treatment. This study was designed to explore the incidence of cognitive frailty among hospitalized elderly patients suffering from cardiovascular disease. It also aimed to analyze the factors influencing its occurrence, thereby providing substantial evidence for the development of early prevention and intervention strategies. From March 2022 to October 2023, under cardiovascular care program, the cardiovascular patients (n = 1190) were subjected to standardized questionnaires to collect demographical characteristics. Also, nutritional and psychosocial assessments tests were performed for the enrolled patients. Multivariate logistic regression analysis was used to evaluate factors associated with cognitive frailty. A total of 1190 (755 males and 435 females) were included. The mean age was 73.36 ± 7.37 years. The prevalence of cognitive frailty in the study population was 33.9% (404/1190). The prevalence of cognitive frailty was 40.7% in men, 22.3% in women. In terms of specific cardiovascular diseases, the prevalence of cognitive frailty was 28.5% in coronary heart disease, 20.5% in arrhythmia, 36.8% in valvular disease, 53% in heart failure, and 13.7% in hypertension. The multivariable analysis showed that age (OR = 1.13, 95% CI: 1.10–1.15, P < .001), anxiety (OR = 1.01, 95% CI: 1.03–1.11, P = .001), female sex (OR = 1.83, 95% CI: 1.10–1.16, P < .001), education level (college and above, OR = 0.27, OR = 0.12–0.64, P = .003), polypharmacy (OR = 2.29, 95% CI: 1.62–3.23, P < .001), comorbidity (OR = 1.93 95% CI: 1.37–2.71, P < .010), region (rural, OR = 1.77, 95% CI: 1.36–2.30, P < .001), sarcopenia (OR = 1.60, 95% CI: 1.16–2.19, P = .004), and nutritional status (risk of malnutrition, OR = 1.66, 95% CI: 1.17–2.35, P = .004; malnutrition exists, OR = 3.24, 95% CI: 1.85–5.83, P < .001) were independently associated with cognitive frailty. The prevalence of cognitive frailty was 33.9% in hospitalized elderly cardiovascular patients in Guangzhou. heart failure, hypertension, age, anxiety, female sex, education level, polypharmacy, comorbidity, region, sarcopenia, and nutritional status were independent risk factors for cognitive frailty.

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Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study

Cited by 4 publications

References 35 publications

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

Current landscape of fecal microbiota transplantation in treating depression

Prevalence and risk factors of cognitive frailty in patients with cardiovascular disease: A hospital-based cross-sectional study

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