Cognitive Function After Intrauterine Growth Restriction and Very Preterm Birth

Morsing, Eva; Åsard, Malena; Ley, David; Stjernqvist, Karin; Maršál, Karel

doi:10.1542/peds.2010-1821

Cited by 186 publications

(147 citation statements)

References 41 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…This was associated with long‐term intrauterine complications, including IUGR and maternal hypertension. IUGR results from placental insufficiency, increases risk for adverse outcome in preterm infants, and, on occasion, may share a common pathogenesis with maternal hypertension 14, 41. It has previously been difficult to dissociate adverse antenatal and postnatal correlates of abnormal brain development.…”

Section: Discussionmentioning

confidence: 99%

Multimodal image analysis of clinical influences on preterm brain development

Ball

Aljabar

Nongena

et al. 2017

Annals of Neurology

View full text Add to dashboard Cite

ObjectivePremature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long‐term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents.MethodsIn a prospective cohort of 449 infants (226 male), we performed a multivariate and data‐driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years.ResultsWe found five independent patterns of neuroanatomical variation that related to clinical factors including age, prematurity, sex, intrauterine complications, and postnatal adversity. We also confirmed the association between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 years.InterpretationThis data‐driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233–246

show abstract

Section: Discussionmentioning

confidence: 99%

Multimodal image analysis of clinical influences on preterm brain development

Ball

Aljabar

Nongena

et al. 2017

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…Morsing et al. 28 described a relationship between intrauterine growth restriction due to absent or reversed end‐diastolic blood flow in the umbilical artery and poor cognitive function among boys of school age. The incidence of intrauterine growth retardation was not known in this study, as we lacked data on intrauterine ultrasound examinations of blood flow.…”

Section: Discussionmentioning

confidence: 99%

Reading deficits in very low birthweight children are associated with vocabulary and attention issues at the age of seven

et al. 2015

View full text Add to dashboard Cite

AimThis Swedish study compared reading skills between seven‐year‐old children with a very low birthweight (VLBW) and controls with a normal birthweight, exploring associations between reading variables and cognition, parent‐rated behaviour, perinatal factors and family factors.MethodsWe studied 51 VLBW children, with no major neurodevelopmental impairments and attending their first year at a regular school, and compared them with the 51 sex‐ and age‐matched controls. The test battery, carried out at 7.8 ± 0.4 years of age, included reading skills, the Wechsler Intelligence Scale for Children – III and the Child Behaviour Checklist.ResultsVery low birthweight children with a mean birthweight of 1105 g (±291 g) and a gestational age of 28.8 (±2.2) weeks scored significantly lower in all reading subtests and cognition and demonstrated more behavioural problems than normal birthweight controls. We also found significant associations between poor vocabulary, combined with attention problems, and phonological awareness, rapid naming and spelling control. Perinatal factors had no association with reading function, and socio‐economic factors had very few.ConclusionVery low birthweight children demonstrated deficits in all reading domains and had poorer cognition and more behavioural problems at the age of seven, with reading ability related to vocabulary and attention.

show abstract

“…Contrary to some other studies that had reported lower total IQ in SGA children (6,9), our findings suggest that being born preterm affects IQ more than does growth restriction. This is more so in verbal IQ than in performance IQ (10). A large population based cohort study reported follow up data of the EPIPAGE cohort at 5 y of age (6).…”

Section: Discussionmentioning

confidence: 99%

“…Some stud ies report lower IQ scores (6,9,10) and more behavioral problems or attention deficits in these children (9) as compared with con trols (6), whereas others have found no differences as regards behavioral problems and attention deficits (6,10). Cognitive impairment was restricted to verbal IQ only (10). Several specific neuropsychologic functions such as motor skills, executive func tioning, memory, visuomotor integration, and visual perception were not studied.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Functional outcome of very preterm–born and small-for-gestational-age children at school age

et al. 2012

View full text Add to dashboard Cite

Background: Our aim was to determine functional outcome of very preterm-born and small-for-gestational-age (sGa) children as compared with matched controls at school age. Methods: We included 28 very preterm sGa children (Ga <32 wk, birth weight (BW) <10th percentile), born in 2000-2001. We also included 28 very preterm but appropriate-forgestational-age (aGa) children, matched for Ga, gender, and birth year, as controls. We assessed motor skills, intelligence quotient (IQ), attention, verbal memory, visual perception, visuomotor integration, executive functioning, and behavior of both sets of children at school age. results: The sGa children had a median Ga of 29.7 wk and BW of 888 g, whereas the controls had a median Ga of 29.4 wk and BW of 1,163 g. at 8.6 y, the median total IQ of the sGa children was 94 as compared with 95 in the controls (not significant). Performance IQ was significantly lower in sGa children (89 vs. 95, P = 0.043), whereas verbal IQ was not (95 vs. 95). Total motor skills (P = 0.048) and fine motor skills (P = 0.021) were worse in sGa children. Furthermore, sGa children scored lower on selective attention (P = 0.026) and visual perception (P = 0.025). Other scores did not differ significantly between groups. conclusion: The differences we found between the groups were small. This suggests that the impaired functioning of very preterm-born sGa children is attributable to their having been born very preterm rather than to being sGa.

show abstract

Cognitive Function After Intrauterine Growth Restriction and Very Preterm Birth

Cited by 186 publications

References 41 publications

Multimodal image analysis of clinical influences on preterm brain development

Multimodal image analysis of clinical influences on preterm brain development

Reading deficits in very low birthweight children are associated with vocabulary and attention issues at the age of seven

Functional outcome of very preterm–born and small-for-gestational-age children at school age

Contact Info

Product

Resources

About