Cognitive function and quantitative electroencephalogram analysis in subjects recovered from COVID-19 infection

Gaber, Manal M.; Hosny, Hanan; Hussein, Mona; Ashmawy, Mona A.; Magdy, Rehab

doi:10.1186/s12883-023-03518-7

Cited by 4 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, in 2024, researchers employed EEG to analyze sleep patterns in children post-SARS-CoV-2 infection 17 . Although numerous comparative EEG studies have targeted younger demographics [18][19][20] , these investigations often involve limited participant numbers and age ranges. Therefore, it is critical to expand EEG studies to more comprehensively assess the long-term cognitive impacts of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

EEG Signatures of Cognitive Decline after Mild SARS- CoV-2 Infection: An Age-Dependent Study

Sun,

Chen

et al. 2024

Preprint

View full text Add to dashboard Cite

Background and Objectives: Current research on the neurological impact of SARS-CoV-2 primarily focuses on the elderly or severely ill individuals. This study aims to explore the diverse neurological consequences of SARS-CoV-2 infection, with a particular focus on mildly affected children and adolescents. Methods A cohort study was conducted to collect pre- and post-infection resting-state EEG data from 185 participants and 181 structured questionnaires of long-term symptoms across four distinct age groups. The goal was to comprehensively evaluate the impact of SARS-CoV-2 infection on these different age demographics. The study analyzed EEG changes of SARS-CoV-2 by potential biomarkers across age groups using both spatial and temporal approaches. Results Spatial analysis indicated that children and adolescents exhibit smaller changes in brain network and microstate patterns post-infection, implying a milder cognitive impact. Sequential linear analyses showed that SARS-CoV-2 infection is associated with a marked rise in low-complexity, synchronized neural activity within low-frequency EEG bands. This is evidenced by a significant increase in Hjorth Activity within the theta band and Hjorth Mobility in the delta band. Sequential nonlinear analysis indicated a significant reduction in the Hurst exponent across all age groups, pointing to increased chaos and complexity within the cognitive system following infection. Furthermore, linear regression analysis based on questionnaires established a significant positive relationship between the magnitude of changes in these neural indicators and the persistence of long-term symptoms post-infection. Discussion The findings underscore the enduring neurological impacts of SARS-CoV-2 infection, marked by cognitive decline and increased EEG disarray. Although children and adolescents experienced milder effects, cognitive decline and heightened low-frequency electrical activity were evident. These observations might contribute to understanding potential anxiety, insomnia, and neurodevelopmental implications.

show abstract

Section: Introductionmentioning

confidence: 99%

EEG Signatures of Cognitive Decline after Mild SARS- CoV-2 Infection: An Age-Dependent Study

Sun,

Chen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database

Calzada-Reyes,

Galán-García,

Virués-Alba

et al. 2024

Preprint

View full text Add to dashboard Cite

BackgroundThe EEG constitutes a powerful neuroimaging technique for assessing functional brain impairment in COVID-19 patients.ObjectiveThe current investigation compared the EEG among COVID-19 survivors, close contacts and the Cuban EEG normative database, using semi-quantitative visual EEG inspection, quantitative and the current source density measures EEG analysis.MethodsThe resting-state EEG activity, quantitative QEEG, and VARETA inverse solution, were evaluated in 173 subjects: 87 patients confirmed cases by the positive reverse transcription polymerase chain reaction (RT-PCR), 86 close contacts (negative PCR) and the Cuban EEG normative database. All patients were physical, neurological, and clinically assessed using neurological retrospective survey and version 2.1 of the Schedules for Clinical Assessment in Neuropsychiatry (SCAN).ResultsThe GTE score showed significant differences in terms of frequency scores of backgrounds rhythmic activity, diffuse slow activity, and focal abnormality. The QEEG analysis showed a pattern of abnormality with respect to the Cuban EEG normative values, displaying an excess of alpha and beta activities in the fronto-central-parietal areas in both groups. The anomalies, of COVID-19 patients and close contacts, differs in the right fronto-centro parietal area. The COVID 19 group differed-s from the close control group in theta band of the right parieto-central. The symptomatic group of COVID-19 patients differs from asymptomatic patients in delta and theta activities of the parieto-central region. The sources of activation using VARETA showed a difference in cortical activation patterns at alpha and beta frequencies in the groups studied with respect to the normative EEG database. In beta frequency were localized in right middle temporal gyrus in both groups and right angular gyrus in Covid 19 group only. In alpha band, the regions were the left supramarginal gyrus for Covid 19 group and the left superior temporal gyrus for Control group. Greater activation was found in the right middle temporal gyrus at alpha frequency in COVID-19 patients than in their close contacts.ConclusionsBrain functions are impaired in long COVID-19 patients. QEEG and VARETA permit us to comprehend the susceptibility of particular brain regions exposed to viral illness.HighlightsBackground frequency abnormalities diffuse slow activity and focal abnormality associated with a pattern of excess oftheta, alpha and beta energies in in the right fronto-centro-parietal regions in QEEG analysis characterizedCOVID-19 patients.Patients with COVID-19 show more alpha and beta EEG activities related to normative EEG database.Patients with COVID-19 and close contacts show high cortical activation in temporo-parietal areas in alpha and beta bands compared to normative EEG database.Patients with COVID-19 (positive PCR) have high activation in the right middle frontal gyrus for alpha band related to close contacts.

show abstract

EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study

Sun,

Chen

et al. 2024

BMC Med

View full text Add to dashboard Cite

Background Current research on the neurological impact of SARS-CoV-2 primarily focuses on the elderly or severely ill individuals. This study aims to explore the diverse neurological consequences of SARS-CoV-2 infection, with a particular focus on mildly affected children and adolescents. Methods A cohort study was conducted to collect pre- and post-infection resting-state electroencephalogram (EEG) data from 185 participants and 181 structured questionnaires of long-term symptoms across four distinct age groups. The goal was to comprehensively evaluate the impact of SARS-CoV-2 infection on these different age demographics. The study analyzed EEG changes of SARS-CoV-2 by potential biomarkers across age groups using both spatial and temporal approaches. Results Spatial analysis indicated that children and adolescents exhibit smaller changes in brain network and microstate patterns post-infection, implying a milder cognitive impact. Sequential linear analyses showed that SARS-CoV-2 infection is associated with a marked rise in low-complexity, synchronized neural activity within low-frequency EEG bands. This is evidenced by a significant increase in Hjorth activity within the theta band and Hjorth mobility in the delta band. Sequential nonlinear analysis indicated a significant reduction in the Hurst exponent across all age groups, pointing to increased chaos and complexity within the cognitive system following infection. Furthermore, linear regression analysis based on questionnaires established a significant positive relationship between the magnitude of changes in these neural indicators and the persistence of long-term symptoms post-infection. Conclusions The findings underscore the enduring neurological impacts of SARS-CoV-2 infection, marked by cognitive decline and increased EEG disarray. Although children and adolescents experienced milder effects, cognitive decline and heightened low-frequency electrical activity were evident. These observations might contribute to understanding potential anxiety, insomnia, and neurodevelopmental implications.

show abstract

Cognitive function and quantitative electroencephalogram analysis in subjects recovered from COVID-19 infection

Cited by 4 publications

References 40 publications

EEG Signatures of Cognitive Decline after Mild SARS- CoV-2 Infection: An Age-Dependent Study

EEG Signatures of Cognitive Decline after Mild SARS- CoV-2 Infection: An Age-Dependent Study

EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database

EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study

Contact Info

Product

Resources

About