Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow

Tideman, Eva; Maršál, Karel; Ley, David

doi:10.1002/uog.4042

Cited by 78 publications

(59 citation statements)

References 30 publications

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“…In the past the focus has been to reduce near term mortality and morbidity, but recent studies have documented adverse long term neurological sequelae even in those fetuses subjected to hypoxia for a short duration 37 . Hence the role of Doppler has shifted from a curative to a preventive one with truly informed and meaningful brain-oriented fetal care becoming a clinical reality .The advent of the aortic isthmus as the new vessel of hope in analyzing early disruption in the cerebral perfusion, is in this direction 35 .…”

Section: Resultsmentioning

confidence: 99%

Colour Doppler in IUGR- Where are we and where do we go?

Lulla

Garg

2010

J Obstet Gynecol India

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Intra-uterine growth restriction (IUGR) is an important perinatal problem giving rise to increased morbidity and mortality in the growth restricted fetus. The aim of fetal medicine today, is to prevent the mere occurrence of IUGR in high risk pregnancies and to deliver the fetuses already afflicted with growth restriction, before they have suffered from the effects of hypoxia. The use of Doppler provides this information, which is not readily obtained from the other conventional tests of fetal well being. The Doppler patterns follow a longitudinal trend in the arterial and venous circulation of the fetus as well as the placental vasculature guiding management decisions regarding the appropriate time of delivery. Progressive knowledge of the fetal circulation and its adaptation when the fetus is subjected to hypoxia, has helped us recognize the early signs of IUGR thereby improving the prognosis of these complicated pregnancies. It has therefore become the gold standard in the management of the growth-restricted fetus.

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Section: Resultsmentioning

confidence: 99%

Colour Doppler in IUGR- Where are we and where do we go?

Lulla

Garg

2010

J Obstet Gynecol India

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“…The cardiovascular system is the first functional organ to develop in the mammalian embryo, and thus, the disruption of the vascular system is important for the identification of compounds with developmental toxicity (3,4). Disruption of vascular development has been correlated with fetal loss, human malformations, and cognitive impairment (5,6). Standard protocols for assessing the effect of chemicals on vascular development involve testing on animals.…”

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confidence: 99%

High-throughput identification of small molecules that affect human embryonic vascular development

Vazão

Rosa

Barata

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biological pathways and potential adverse consequences in humans. To develop a screening platform for molecules that affect human embryonic development based on endothelial cells (ECs) derived from human pluripotent stem cells, we differentiated human pluripotent stem cells into embryonic ECs and induced their maturation under arterial flow conditions. These cells were then used to screen compounds that specifically affect embryonic vasculature. Using this platform, we have identified two compounds that have higher inhibitory effect in embryonic than postnatal ECs. One of them was fluphenazine (an antipsychotic), which inhibits calmodulin kinase II. The other compound was pyrrolopyrimidine (an antiinflammatory agent), which inhibits vascular endothelial growth factor receptor 2 (VEGFR2), decreases EC viability, induces an inflammatory response, and disrupts preformed vascular networks. The vascular effect of the pyrrolopyrimidine was further validated in prenatal vs. adult mouse ECs and in embryonic and adult zebrafish. We developed a platform based on human pluripotent stem cell-derived ECs for drug screening, which may open new avenues of research for the study and modulation of embryonic vasculature.high-throughput screening | endothelial cells | vascular toxicity | pluripotent stem cells | embryonic endothelial markers

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“…low birth weight in humans [30,39,42,148], existing studies do suggest long-term structural 283 damage following experimental IUGR. These include damage which occurs during exposure to 284 restriction and persist from fetal life, such as decreased neuronal density [117], which can be 285 contributed by grey matter loss in utero resulting in decreased neuron numbers in later life.…”

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confidence: 99%

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Hunter

Hazel

Kind

et al. 2016

Physiology & Behavior

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Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow

Abstract: Objective Intrauterine growth restriction (IUGR) is

Cited by 78 publications

References 30 publications

Colour Doppler in IUGR- Where are we and where do we go?

Colour Doppler in IUGR- Where are we and where do we go?

High-throughput identification of small molecules that affect human embryonic vascular development

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

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