Cognitive function in young and adult IL (interleukin)-6 deficient mice

Braida, Daniela; Sacerdote, Paola; Panerai, Alberto E.; Bianchi, Mauro; Aloisi, Anna Maria; Iosuè, Stefania; Sala, Mariaelvina

doi:10.1016/j.bbr.2003.12.018

Cited by 151 publications

(86 citation statements)

References 40 publications

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“…Mammalian studies in which levels of proinflammatory cytokines are increased to pathogenic levels, either through direct injection or indirectly via induction of inflammation through injection of lipopolysaccharide or bacteria, tend to suggest that augmented cytokine signaling is detrimental for performance in a variety of learning and memory assays (48,49). This negative impact of cytokine signaling on memory is supported by studies that take a loss-of-function approach to address the physiological function of interleukins and their receptors in different cognitive tasks under nonpathological conditions (50,51). On the other hand, several studies describe learning and memory defects attributed to loss of function of other cytokines or their receptors, using a variety of behavioral assays (52,53).…”

Section: Discussionmentioning

confidence: 99%

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

Copf

Goguel²,

Lampin-Saint-Amaux³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue-and adult-specific expression of RNAi and dominantnegative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms.

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Section: Discussionmentioning

confidence: 99%

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

Copf

Goguel²,

Lampin-Saint-Amaux³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…Conversely, IL-6 receptor antagonists prevent inflammation-related disruption of hippocampal LTP and ensuing cognitive sequelae (18). Finally, IL-6 knockout mice show facilitated working memory when compared with wild type mice (19) and are refractory to peripheral endotoxin-induced impairments of spatial memory (20). Together, these animal findings suggest that higher peripheral IL-6 is associated with hippocampal inflammatory mechanisms that negatively affect cognitive processes, including memory and learning.…”

Section: Introductionmentioning

confidence: 94%

Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults

Marsland

Gianaros

Abramowitch

et al. 2008

Biological Psychiatry

309

224

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Background-Converging animal findings suggest that higher peripheral levels of inflammation are associated with activation of central inflammatory mechanisms that result in hippocampal neurodegeneration and related impairment of memory function. Consistent with animal findings, we have recently shown an inverse association between peripheral levels of interleukin-6 (IL-6), a relatively stable marker of systemic inflammation, and memory function in mid-life adults. In the current study, we extend this work to test whether systemic inflammation is associated with reduced grey matter volume of the hippocampus.

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“…Studies using transgenic mice have reported that IL-6 deletion has a facilitatory effect on learning and memory (Braida et al 2004) while chronic IL-6 expression from astrocytes in the brain results in a decline in avoidance learning performance (Heyser et al 1997). These findings suggest that the persistence of excessive IL-6 signaling has a negative impact on the cognitive performance.…”

Section: As Well As In Patients Withmentioning

confidence: 99%

Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

et al. 2011

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Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P=0.005).Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

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Cognitive function in young and adult IL (interleukin)-6 deficient mice

Cited by 151 publications

References 40 publications

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults

Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

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