Cognitive Function May be a Predictor of Retinopathy Progression in Patients with Type 2 Diabetes

Trento, Marina; Charrier, Lorena; Salassa, Martina; Merlo, Stefano; Passera, P; Baltatescu, Anatolie; Cavallo, Franco; Porta, Massimo

doi:10.5301/ejo.5000885

Cited by 9 publications

(11 citation statements)

References 12 publications

(12 reference statements)

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“…Three of the 22 studies examined people with Type 1 diabetes, [23,29,30] nine examined people with Type 2 diabetes, [16][17][18][19][31][32][33][34][35] and 6 examined people with either Type 1 or Type 2 diabetes [36][37][38][39][40][41]. Four studies did not specify the type of diabetes [42][43][44][45].…”

Section: Search Resultsmentioning

confidence: 99%

“…Twelve studies quantified the results in terms of Cox proportional HRs, [16][17][18][19][31][32][33]36,38,41,42,45] while others used ORs, [29,30,35,40,43,44] RR [37], or provided regression coefficients [39]. Two papers briefly explained that depression did not increase incident diabetes complications but neither provided numerical data [23,34]. Of the 12 studies reporting Cox proportional HRs, 10 concerned depression as a risk factor for the onset of diabetes complications and 2 concerned the relationship from diabetes complications to incident depression.…”

Section: Search Resultsmentioning

confidence: 99%

“…Another study found a significantly increased risk only for angina (HR = 1.40; 95% CI: 1.06–1.84), but not for the objective, coronary artery disease (no statistics were provided for the latter). In terms of microvascular complications, results were mixed, with three studies supporting and two failing to support the findings of the meta‐analysis . Regarding incident foot ulcers, one study found that there was a linear relationship between increased risk and the severity of depressive symptoms .…”

Section: Resultsmentioning

confidence: 99%

“…For macrovascular complications, the results of these studies generally concurred with those obtained in the meta‐analysis, except for one . For microvascular complications, results were mixed, with three supporting and two failing to support the findings of the meta‐analysis. Of the latter, one examined participants during their first two years of newly diagnosed diabetes , and the other had cognitive function as the main predictor variable .…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal associations between depression and diabetes complications: a systematic review and meta‐analysis

et al. 2019

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To conduct a systematic review and meta‐analysis of longitudinal studies assessing the bi‐directional association between depression and diabetes macrovascular and microvascular complications. Embase, Medline and PsycINFO databases were searched from inception through 27 November 2017. A total of 4592 abstracts were screened for eligibility. Meta‐analyses used multilevel random/mixed‐effects models. Quality was assessed using the Newcastle‐Ottawa scale. Twenty‐two studies were included in the systematic review. Sixteen studies examined the relationship between baseline depression and incident diabetes complications, of which nine studies involving over one million participants were suitable for meta‐analysis. Depression was associated with an increased risk of incident macrovascular (HR = 1.38; 95% CI: 1.30–1.47) and microvascular disease (HR = 1.33; 95% CI: 1.25–1.41). Six studies examined the association between baseline diabetes complications and subsequent depression, of which two studies involving over 230 000 participants were suitable for meta‐analysis. The results showed that diabetes complications increased the risk of incident depressive disorder (HR = 1.14; 95% CI: 1.07–1.21). The quality analysis showed increased risk of bias notably in the representativeness of selected cohorts and ascertainment of exposure and outcome. Depression in people with diabetes is associated with an increased risk of incident macrovascular and microvascular complications. The relationship between depression and diabetes complications appears bi‐directional. However, the risk of developing diabetes complications in depressed people is higher than the risk of developing depression in people with diabetes complications. The underlying mechanisms warrant further research.

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Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Longitudinal associations between depression and diabetes complications: a systematic review and meta‐analysis

et al. 2019

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“…Durante la tercera edad, esta patología ha demostrado que no sólo es un factor de riesgo importante para el desarrollo de retinopatía, amputaciones no traumáticas de miembros inferiores y enfermedad renal 7,8 , sino que también aumenta el riesgo de deterioro cognitivo y, por ende, el desarrollo de demencia 9,10 . En este contexto, diversos estudios epidemiológicos han demostrado que adultos mayores diabéticos son más susceptibles a desarrollar enfermedad de Alzheimer y demencia vascular que aquellos no diabéticos [11][12][13] . Sin embargo, a pesar de que la DMT2 es considerada un factor de riesgo independiente para el deterioro cognitivo [14][15][16] , la función cognitiva de los pacientes diabéticos generalmente no es evaluada en la práctica clínica diaria 17 .…”

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Asociación entre diabetes mellitus tipo 2, historia familiar de diabetes y deterioro cognitivo en adultos mayores chilenos

et al. 2018

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representación de todos los integrantes del grupo elHoc, Epidemiology of Lifestyle and Health Outcomes in Chile) Risk of cognitive impairment among older people with diabetes or family history of the disease Background: Although cardiovascular risk factors are associated with an impaired cognitive function, the impact of diabetes on cognitive function in Chilean adults is unknown. Aim: To investigate the association of diabetes or family history of the disease with cognitive impairment in older adults. Materials and Methods: Data from the 2009-2010 Chilean National Health Survey including 1,384 participants aged ≥ 60 years were included in this study. A score below 13 points for the Mini Mental State Examination (MMSE) was considered an indication of cognitive impairment. Logistic regression analyses were performed to assess the association between MMSE, diabetes and family history of the disease. Results: Cognitive impairment increased with age (Odds ratio (OR): 1.83 [95% confidence intervals (CI): 1.53; 2.19], p < 0.01, per 5 years increment in age). This trend was greater in individuals with diabetes (OR: 2.37 [95% CI: 1.68; 3.35], p < 0.01) compared to those without the disease. A similar trend was identified among individuals with a family history of diabetes compared to those without. Conclusions: Older adults with diabetes are more susceptible to develop cognitive impairment.

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Association of midlife cognition impairment with diabetic retinopathy in type 2 diabetes mellitus in an Indian population

Mukherjee

Ghosh

2022

Practical Diabetes

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Purpose: Cognitive impairment is associated with worsening of diabetic retinopathy (DR). While cognitive impairment has been observed in the elderly with DR, no report on cognition is available in middle‐aged patients with DR. We explored the association between midlife cognitive impairment and DR in an Indian population cohort.Methods: We undertook an institutional analytical cross‐sectional study with middle‐aged type 2 diabetes mellitus patients; there were 36 cases with DR and 36 patients without DR (NODR). Cognition was assessed by mini‐mental state examination (MMSE) questionnaires and compared between both groups.Results: The median age was 55 years in the DR group and 53.5 years in the NODR group. The MMSE score in DR (23.5 ± 3.3, 95% CI 22.3–24.6) was lower (p = 0.015) than in NODR (25.3 ± 3.3, 95% CI 24.2–26.5). The MMSE score in DR was lower in all the domains except for that of language. MMSE score in females (23.1 ± 3.4) was lower (p = 0.001) than in males (25.8 ± 3.0). Education‐adjusted MMSE score was normal among 31 (86.1%) in NODR and 21 (58.3%) in DR (p = 0.009). Dementia was present in 36.1% of cases with DR and 13.9% of cases with NODR. Those with DR had a 4.8 times chance of having education‐adjusted cognitive impairment compared to NODR (p = 0.046, odds ratio 4.8, 95% CI 1.0–22.7). Compared to NODR cases, the chances of having education‐adjusted cognitive impairment increased in mild non‐proliferative DR (p < 0.001, odds ratio 1.8, 95% CI 0.3–11.1), moderate non‐proliferative DR (p = 0.002, odds ratio 4.3, 95% CI 1.1–16.8), and advanced DR (p < 0.001, odds ratio 9.30, 95% CI 1.92–45.10).Conclusions: DR was positively associated with cognitive impairment in middle age in this sample of the Indian population. Copyright © 2022 John Wiley & Sons.

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Cognitive Function May be a Predictor of Retinopathy Progression in Patients with Type 2 Diabetes

Abstract: Cognitive function may be an independent predictor of retinopathy progression.

Cited by 9 publications

References 12 publications

Longitudinal associations between depression and diabetes complications: a systematic review and meta‐analysis

Longitudinal associations between depression and diabetes complications: a systematic review and meta‐analysis

Asociación entre diabetes mellitus tipo 2, historia familiar de diabetes y deterioro cognitivo en adultos mayores chilenos

Association of midlife cognition impairment with diabetic retinopathy in type 2 diabetes mellitus in an Indian population

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