Cognitive Functioning and Depression in Patients With Chronic Fatigue Syndrome and Multiple Sclerosis

Krupp, Lauren; Sliwinski, Martin J.; Masur, David; Friedberg, Fred; Coyle, P. K.

doi:10.1001/archneur.1994.00540190089021

Cited by 142 publications

(96 citation statements)

References 16 publications

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“…As Table 1 illustrates, existing studies are evenly divided between studies that reported null effects (12) and those reporting significant associations (10). Regarding the studies reporting null findings, the majority (10 of 12) were characterized by small sample sizes, suggesting that low statistical power could account for the absence of significant effects (DeLuca et al, 1994;Fischer, 1988;Grafman et al, 1991;Krupp et al, 1994;Millefiorini et al, 1992;Minden & Schiffer, 1990;Moller et al, 1994;Rao et al, 1984Rao et al, , 1989bSchiffer & Caine, 1991). The other study reporting null findings (Good et al, 1992) excluded significantly depressed MS patients from their sample.…”

Section: Cognitive Dysfunctionmentioning

confidence: 99%

Depression in multiple sclerosis: Review and theoretical proposal

Arnett

Barwick

Beeney

2008

J Int Neuropsychol Soc

220

175

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Because of its high prevalence and implications for quality of life and possibly even disease progression, depression has been intensively studied in multiple sclerosis (MS) over the past 25 years. Despite the publication of numerous excellent empirical research papers on this topic during that time, the publication of theoretical work that attempts to explain depression in a comprehensive way is scarce. In this study, we present a theoretical model that attempts to integrate existing work on depression in MS and provide testable hypotheses for future work. The model suggests that risk for depression begins with the onset of MS. MS results in disease-related changes such as increased lesion burden0brain atrophy and immunological anomalies that are associated with depression in MS, but explain only a relatively limited proportion of the variance. Common sequelae of MS including fatigue, physical disability, cognitive dysfunction, and pain, have all been shown to have an inconsistent or relatively weak relationship to depression in the literature. In the model, we propose that four variables-social support, coping, conceptions of the self and illness, and stress-may moderate the relationship between the above common MS sequelae with depression and help to explain inconsistencies in the literature. (JINS, 2008, 14, 691-724.)

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Section: Cognitive Dysfunctionmentioning

confidence: 99%

Depression in multiple sclerosis: Review and theoretical proposal

Arnett

Barwick

Beeney

2008

J Int Neuropsychol Soc

220

175

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“…Some studies have indicated that patients with MS-related cognitive impairment report higher levels of depression than patients without cognitive impairment [24][25]. Other studies do not support this relationship [26][27]. Some evidence exists that the specific type of cognitive impairment may be differentially related to depression.…”

Section: Physical and Cognitive Impairmentmentioning

confidence: 99%

Depression and multiple sclerosis: Review of a lethal combination

Wallin¹,

Wilken

Turner

et al. 2006

JRRD

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Abstract-Depression is the most frequent psychiatric disorder in multiple sclerosis (MS) patients. The etiology of depression is multifactorial and likely associated with psychosocial stress, focal demyelinating lesions, and immune dysfunction. Proper diagnosis and severity assessment are critical prior to initiation of therapy. Patients with suicidal ideation should be referred for immediate psychiatric consultation and be closely monitored. While more therapeutic trials for depression in MS are needed, MS patients have been shown to respond to current antidepressant medications and psychotherapy. Unfortunately, patients with MS and major depression or suicidal thoughts are often underassessed and therefore not diagnosed. Unlike other aspects of MS, depression is treatable. Early intervention in depression can prevent declines in quality of life and even death from suicide. This article reviews the unique features, assessment, and treatment of depression in MS. MS care providers should vigilantly assess depression and suicide risk in their patients.

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“…Based on these results, the investigators concluded CFS subjects do not experience primary verbal memory impairments, but rather experience impairments in information processing efficiency and may have difficulty with complex tasks that require simultaneous processing of several cognitive activities. Krupp et al (1994) compared the performarlce of twenty CFS patients to twenty MS patients matched for fatigue severity, age, and education and to twenty age-and education-matched healthy control subjects. The subjects were administered a series of tests measuring verbal memory, attention, visual-motor search, verbal fluency, and abstract reasoning.…”

Section: Studies Employing Control Groupsmentioning

confidence: 99%

Neurocognitive functioning in chronic fatigue syndrome

DiPino

Kane

1996

Neuropsychol Rev

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Although substantial research has been conducted on chronic fatigue syndrome (CFS) over the past decade, the syndrome remains poorly understood. The most recent case definition describes CFS as being characterized both by disabling fatigue and by subjective reports of difficulty with concentration and "short-term" memory. However, research into the neurocognitive and psychological functioning of individuals with CFS has provided mixed objective results. The current paper reviews studies that have examined the neurocognitive and/or psychological functioning of individuals with CFS. Changes in research design and instruments employed to study individuals with CFS are suggested.

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Cognitive Functioning and Depression in Patients With Chronic Fatigue Syndrome and Multiple Sclerosis

Cited by 142 publications

References 16 publications

Depression in multiple sclerosis: Review and theoretical proposal

Depression in multiple sclerosis: Review and theoretical proposal

Depression and multiple sclerosis: Review of a lethal combination

Neurocognitive functioning in chronic fatigue syndrome

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