Cognitive functioning in a representative cohort of preschool children with febrile seizures

Billstedt, Eva; Nilsson, Gill; Leffler, Lotta; Carlsson, Lisa; Olssøn, Ingrid; Fernell, Elisabeth; Gillberg, Christopher

doi:10.1111/apa.15059

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…In general, no association was demonstrated, but a possible relation between cognitive function and FS was found in the youngest age group who had experienced FS before the age of one year 23 . In our previous report, 14 we had similar results, i.e., children with early onset of FS (before 12 months of age)—who often had recurrent FS—had lower full‐scale, verbal and processing speed IQ than those who had later onset of FS.…”

Section: Discussionsupporting

confidence: 53%

“…Out of the 157 children with a history of FS, 73 (41 boys, 32 girls) participated in a clinical assessment when they were 4–5 years old. The results from this study have been described in earlier papers 8,14 . 5 years later, the parents of these 73 children were contacted by letter and then by telephone to ask them to participate in a telephone interview.…”

Section: Methodsmentioning

confidence: 97%

“…The study population has been described in earlier studies 3,8,14 and consisted of all 4‐year‐old children, born between July 1, 2008, and June 30, 2009, and living in the city of Gothenburg in 2012 and 2013 ( N = 6076). A questionnaire screening for any type of seizures, including FS, was distributed to parents at the Child Health Care Centers (CHCs) in Gothenburg when the children were 4 years of age.…”

Section: Methodsmentioning

confidence: 99%

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Neurodevelopmental problems in children with febrile seizures followed to young school age: A prospective longitudinal community‐based study in Sweden

et al. 2021

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Aim To estimate the accumulated prevalence of neurodevelopmental problems from preschool to school age in children with a history of febrile seizures (FS). Methods In a community‐based cohort of children with previous FS, 25/73 clinically assessed children met diagnostic criteria for neurodevelopmental disorders or had major indications of such problems at the age of 4–5 years. Parents of 54 of the 73 children accepted to take part in an interview according to the Autism‐Tics, ADHD and other Comorbidities (A‐TAC) inventory, when the children were 9–10 years. Results There was a trend for ADHD symptom scores to be higher in the FS group. Non‐participants at age 9–10 years had had much higher rates of neurodevelopmental problems at 4–5 years, and the total number of such problems at either 4–5 or age 9–10 was 41% (30/73). Conclusion High rates of neurodevelopmental problems (41%) were found at either age 4–5 or 9–10 years or both in this group of 73 children with FS. Non‐participants at 9–10 years had had much higher rates of neurodevelopmental problems at 4–5 years. Further follow‐up of this cohort is needed before definite conclusions can be drawn about whether FS should be considered a marker for more complex neurodevelopmental problems.

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Section: Discussionsupporting

confidence: 53%

Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

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Neurodevelopmental problems in children with febrile seizures followed to young school age: A prospective longitudinal community‐based study in Sweden

et al. 2021

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“…With regard to intellectual and behavioral outcomes of children with febrile seizures, a population-based study of children born in one week in April 1970 in the UK found no differences between children with and without febrile seizures [ 27 ]. A recent study from Sweden, however, showed that children with early onset of febrile seizures and those with recurrent febrile seizures may be at risk for developing cognitive executive dysfunctions [ 3 ]. Nevertheless, the developmental prognosis is usually considered to be relatively favorable.…”

Section: Discussionmentioning

confidence: 99%

Febrile seizures: perceptions and knowledge of parents of affected and unaffected children

et al. 2021

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Febrile seizures (FS) in children are common, but little is known about parents’ perceptions and knowledge of FS. We interviewed parents of children aged 6 months to 6 years affected by FS (FS group, 65 parents) or unaffected (control group, 54 parents). In the FS group, 32% said they knew their child had an FS when the first event occurred, and 89% described fear when the child had a seizure, with a median intensity of 10/10 (Q25/Q75: 9/10). Related to follow-up, 77% in the FS group (will) observe their child more carefully after the first seizure happened, and 63% (will) give antipyretics earlier at a median temperature of 38.2 °C (100.8 °F). In the FS group, 62% were unaware of FS before the first event (54% of control group did not know about FS thus far, n.s.). In the FS group, 20% would put a solid object in the mouth of a child having a seizure (control group, 39%, p = 0.030), and 92% would administer an available anti-seizure rescue medication (control group, 78%, p = 0.019). In the FS group, 71% feared that children with FS might suffocate (control group, 70%, n.s.).Conclusion: Information about FS and their management should be more available to improve parents’ coping and patient safety. What is Known:• Febrile seizures in children are common.• The prognosis of children suffering from febrile seizures is usually rather good. What is New:• Over half of parents had not informed themselves about febrile seizures so far; and only 32% of parents realized their child had a febrile seizure when it occurred.• Most parents described own fear with a median intensity of 10/10; and 63% (will) give antipyretics earlier at a median temperature of 38.2 °C (100.8 °F).

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“…Based on objective measures, evidence has pointed to weaker sustained attention in children who have suffered CFS [27]. Yet, studies have failed to identify executive deficits, although this may be due to lumping together the different FS groups [11,12,28]. Still, Billstedt et al [28] have argued that recurrent seizures and a younger age at onset are risk factors for cognitive deficits in children with FS.…”

mentioning

confidence: 99%

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age

Sheppard¹,

Lalancette²,

Thébault-Dagher³

et al. 2021

Epileptic Disorders

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Objective. Our goal was to assess development, cognition and behaviour following an initial complex febrile seizure (FS), at onset and school age, in the context of known risk factors for cognitive development. Methods. Two cohorts were recruited. Thirty-five infants with an initial complex FS were assessed within the first year post-seizure and compared to 30 controls (simple FS) based on measures of cognitive, motor and language development, behaviour and emotions. Additionally, 19 school-age children with previous complex FS (11 multiple, eight prolonged) were assessed and compared to 19 controls (simple FS) based on measures of intelligence, learning/memory, executive functioning, behaviour and emotions. Results. Within the first year post-onset, infants with complex FS did not significantly differ from controls based on developmental measures. Seizure duration and age at seizure onset did not impact developmental outcome. School-age children with complex FS showed unaltered global intelligence, but lower executive functioning, compared to controls. Children with prolonged FS also showed evidence of a lower level of learning and memory abilities. Neuropsychological scores correlated with seizure duration. Children with complex FS showed more attentional problems and anxious/depressed symptomatology at onset and school age, and more hyperactivity at school age. Significance. Infants with complex FS seemed to show normal development within the first year post-seizure onset. However, challenges in executive functioning, learning and memory at school age were found in children with a history of FS. Hence, at school age, cognitive challenges cannot be excluded based on undifferentiated early cognitive development, and may occur even in the absence of the most severe form of FS (i.e., FSE). Beyond the limits of this study (i.e., small sample size, use of parental questionnaires for emotional/behavioural outcome, absence of focal cases in the school-age cohort), our results suggest that a follow-up is necessary beyond the early preschool years in order to understand the long-term outcome.

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Cognitive functioning in a representative cohort of preschool children with febrile seizures

Cited by 5 publications

References 23 publications

Neurodevelopmental problems in children with febrile seizures followed to young school age: A prospective longitudinal community‐based study in Sweden

Neurodevelopmental problems in children with febrile seizures followed to young school age: A prospective longitudinal community‐based study in Sweden

Febrile seizures: perceptions and knowledge of parents of affected and unaffected children

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age

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