Cognitive functions in euthymic Egyptian patients with bipolar disorder: Are they different from healthy controls?

Okasha, Tarek; Sheikh, Mona M. El; Missiry, Ahmed A. El; El-Serafi, Doha; Kholy, Suzan El; Aziz, Karim Abdel

doi:10.1016/j.jad.2014.04.051

Cited by 16 publications

(8 citation statements)

References 34 publications

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“…The main cognitive domains measured by LNS are attention and working memory (Wechsler, 2008). Here it is worth mentioning that previous studies have found that euthymic patients with bipolar disorder performed worse than healthy controls on both the LNS test and the long-term free recall test (Martínez-Arán et al, 2004; Okasha et al, 2014; Vasconcelos-Moreno et al, 2016), suggesting that cognitive deficits in these domains may be long lasting in bipolar disorder.…”

Section: Discussionmentioning

confidence: 72%

Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial

et al. 2019

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Objective: The purpose of this study was to assess the efficacy and tolerability of tianeptine as an adjunctive maintenance treatment for bipolar depression. Methods: This is a multicenter double-blind randomized placebo-controlled maintenance trial of adjunctive tianeptine 37.5 mg/day. Participants (n=161) had a Montgomery-Asberg Depression Rating Scale ⩾12 at entry. After eight weeks of open-label tianeptine treatment, those who responded to tianeptine (n=69) were randomized to adjunctive tianeptine (n=36) or placebo (n=33) in addition to usual treatment. Kaplan-Meier estimates and the Mantel-Cox log-rank test were used to evaluate differences in time to intervention for a mood episode between the tianeptine and placebo groups. We also assessed overall functioning, biological rhythms, quality of life, rates of manic switch and serum brain-derived neurotrophic factor levels. Results: There were no differences between adjunctive tianeptine or placebo regarding time to intervention or depression scores in the 24-week double-blind controlled phase. Patients in the tianeptine group showed better performance in the letter-number sequencing subtest from the Wechsler Adult Intelligence Scale at the endpoint (p=0.014). Tianeptine was well tolerated and not associated with higher risk for manic switch compared to placebo. Conclusion: Tianeptine was not more effective than placebo in the maintenance treatment of bipolar depression. There is preliminary evidence suggesting a pro-cognitive effect of tianeptine in working memory compared to placebo.

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Section: Discussionmentioning

confidence: 72%

Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial

et al. 2019

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“…Four studies ( Harvey et al, 2003 ; Okasha et al, 2014 ; Savitz et al, 2009 ; Savitz et al, 2008 ) used nonspecialised health professionals to perform the tests. Most tests were performed by a neuropsychologist; or by trained research assistant/graduate trainee.…”

Section: Resultsmentioning

confidence: 99%

“…Most tests were performed using pen and paper tests ( Gureje et al, 1994 ; Mattson et al, 1997 ; Ertuğrul and Uluğ, 2002 ; Harvey et al, 2003 ; Alptekin et al, 2005 ; Ayres et al, 2007 ; Salgado et al, 2007 ; Pradhan et al, 2008 ; Savitz et al, 2008 ; Savitz et al, 2009 ; de Mello Ayres et al, 2010 ; Ngoma et al, 2010 ; Guo et al, 2011 ; Nakasujja et al, 2012a ; Mazhari et al, 2014 ; Okasha et al, 2014 ; Araujo et al, 2015 ; Hendricks et al, 2017 ; Sagar et al, 2018 ). Limitations of paper based assessments include human error in data collection, the additional time required to score the assessments after they have been administered, costs associated with obtaining copyrighted and proprietary forms, and the burden of transporting and storing hard-copy questionnaires ( Robbins et al, 2014a ).…”

Section: Discussionmentioning

confidence: 99%

A systematic review of research on neuropsychological measures in psychotic disorders from low and middle-income countries: The question of clinical utility

Mwesiga

Akena

Koen

et al. 2020

Schizophrenia Research: Cognition

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Introduction Several studies of neuropsychological measures have been undertaken in patients with psychotic disorders from low- and middle-income countries (LMICs). It is, however, unclear if the measures used in these studies are appropriate for cognitive screening in clinical settings. We undertook a systematic review to determine if measures investigated in research on psychotic disorders in LMICs meet the clinical utility criteria proposed by The Working Group on Screening and Assessment. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses were employed. We determined if tests had been validated against a comprehensive test battery, the duration and scope of the tests, the personnel administering the tests, and the means of administration. Results A total of 31 articles were included in the review, of which 11 were from Africa. The studies included 3254 participants with psychosis and 1331 controls. 3 studies reported on the validation of the test against a comprehensive cognitive battery. Assessments took 1 h or less to administer in 6/31 studies. The average number of cognitive domains assessed was four. Nonspecialized staff were used in only 3/31 studies, and most studies used pen and paper tests (17/31). Conclusion Neuropsychological measures used in research on psychotic disorders in LMICs typically do not meet the Working Group on Screening and Assessment clinical utility criteria for cognitive screening. Measures that have been validated in high-income countries but not in LMICs that do meet these criteria, such as the Brief Assessment of Cognition in Schizophrenia, therefore deserve further study in LMIC settings.

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“…All participants were part of a larger research project on Egyptian BD patients. The methodology has previously been outlined in detail [2,6,20,27]. They were recruited over a 2-year period, their age range was between 18 and 45 years, and both sexes were included.…”

Section: Patients Groupmentioning

confidence: 99%

“…There is growing body of research evidence that several cognitive domains are impaired during the acute phases of bipolar disorder (BD) illness [1][2][3]. These cognitive impairments persist even during the euthymic periods [4][5][6] and they are highly observed in attention, verbal learning, working memory, and executive function [7,8].…”

Section: Introductionmentioning

confidence: 99%

Are there differences in pattern and magnitude of cognitive deficits between euthymic patients with bipolar I and bipolar II disorder?

Okasha¹,

Elmissiry²,

Sabry³

et al. 2016

Middle East Current Psychiatry

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BackgroundRecent preliminarily evidence suggests that types and severity of cognitive dysfunctions may differ between bipolar disorder I and II (BD-I and BD-II). However, available data are scarce and inconsistent. Aim We aimed to investigate the differences in cognitive deficits between BD-I and BD-II patients. Patients and methodsThe study included 60 euthymic patients with BD (30 BD-I and 30 BD-II) from a large ongoing project on Egyptian patients with BD; they were compared on the basis of their neuropsychological variables (e.g. executive function, attention, verbal, and visual memory) and compared with 30 healthy controls on cognitive performance. They were subjected to full neuropsychological battery. ResultsCompared with the healthy controls, patients with BD-I and BD-II showed significant impairment in the majority of cognitive tasks including working memory (digit span backwards, P = 0.000), verbal memory (verbal paired association I and II, P = 0.000), sustained attention (total errors of omission, P = 0.028), and overall executive functions (categories completed, P = 0.000). Post-hoc analysis showed the patients with BD-II having an intermediate level of performance in cognitive functions, between patients with type I disorder and healthy participants, and almost preserved executive functions compared with BD-I patients. ConclusionThis study showed differences in severity and pattern of cognitive deficits between BD subtypes, and so the difference is not merely quantitative as confirmed by most of the previous studies. However, there were also qualitative differences in the pattern of executive function deficits, being more extensive in BD-I, which may indicate different biological or genetic etiology between the two BD subgroups. Future researches are needed to support this hypothesis.

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Cognitive functions in euthymic Egyptian patients with bipolar disorder: Are they different from healthy controls?

Cited by 16 publications

References 34 publications

Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial

Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial

A systematic review of research on neuropsychological measures in psychotic disorders from low and middle-income countries: The question of clinical utility

Are there differences in pattern and magnitude of cognitive deficits between euthymic patients with bipolar I and bipolar II disorder?

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