2017
DOI: 10.1037/neu0000412
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Cognitive genomics: Searching for the genetic roots of neuropsychological functioning.

Abstract: Objective Human cognition has long been known to be under substantial genetic control. With the complete mapping of the human genome, genome-wide association studies (GWAS) for many complex traits have proliferated; however, the highly polygenic nature of intelligence has made the identification of the precise genes that influence both global and specific cognitive abilities more difficult than anticipated. Methods Here, we review the latest developments in the genomics of cognition, including a discussion o… Show more

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Cited by 18 publications
(21 citation statements)
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References 190 publications
(318 reference statements)
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“…Our findings also highlight the importance of g, or general cognitive ability, and lend support to the notion of generalist genes i.e., that a set of generalist genes influence multiple cognitive domains [63]. The generalist gene hypothesis has important practical implications since g can readily be calculated in any study that includes five or more cognitive tests, allowing combining of data from multiple studies and thus increasing power to detect genetic variants underlying cognition [26].…”
Section: Discussionsupporting
confidence: 69%
See 1 more Smart Citation
“…Our findings also highlight the importance of g, or general cognitive ability, and lend support to the notion of generalist genes i.e., that a set of generalist genes influence multiple cognitive domains [63]. The generalist gene hypothesis has important practical implications since g can readily be calculated in any study that includes five or more cognitive tests, allowing combining of data from multiple studies and thus increasing power to detect genetic variants underlying cognition [26].…”
Section: Discussionsupporting
confidence: 69%
“…Between early adulthood and old age, on the other hand, heritability of processing speed and memory decreases [25]. Thus, genetic influences on cognition may vary, not as a linear function of age, but depending on the developmental period and the specific cognitive abilities under investigation [26]. While the moderation of heritability by age is well replicated [3], previous studies have been unable to fully disentangle this effect because age has been categorized into broad developmental periods, rather than investigated as a continuous factor.…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless our findings suggest the influence of “generalist genes,” that is genes or genetic factors that influence neuroanatomic variation across multiple rather than specific features of anatomy. Similar arguments have been made about the genetic architecture of general intelligence versus more specific domains of cognition (Bearden and Glahn 2017).…”
Section: Discussionsupporting
confidence: 59%
“…Finally, RDoC’s role as a flexible research framework serves as a model for further major revisions to conceptions of mental illness–in the near term, in such growing research areas as connectomics 13 and the genomics of functional systems 14 ; and in the longer term, potentially radical change stemming from computational modeling and machine learning. 15 , 16 …”
Section: Key Rdoc Featuresmentioning
confidence: 99%