Cognitive Impairment during High-Intensity Exercise: Influence of Cerebral Blood Flow

Komiyama, Tokutaro; Tanoue, Yukiya; Sudo, Mizuki; Costello, Joseph; Uehara, Yoshio; Higaki, Yasuki; Andò, Sebastiano

doi:10.1249/mss.0000000000002183

Cited by 23 publications

(28 citation statements)

References 38 publications

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“…Four studies (two of the four studies also used NIRS) used transcranial Doppler to assess cerebral blood flow (CBF) velocity. They found that improvements or impairments in EF during exercise are not directly related to alterations in CBF [23,38,40,42].…”

Section: Facilitation No Effect Impairmentmentioning

confidence: 98%

“…Eleven of the 42 outcomes, within nine studies, employed a vigorous-to high-intensity protocol, of which three found that EF performance was improved [37,40,45]. Eight showed that EF performance was declined [19,21,23,41,46,47]. According to the findings, impaired EF performance most likely occurs during vigorous-to high-intensity exercise.…”

Section: Study Findingsmentioning

confidence: 98%

“…Eight outcomes observed that EF performance was improved [15,24,38,39,42,43]. Eleven outcomes found that EF performance during exercise remained unaltered [19,22,23,25,26,35,39,41,46,47]. Five outcomes found that EF performance was deteriorated [20,22,36,44].…”

Section: Study Findingsmentioning

confidence: 99%

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Concurrent Performance of Executive Function during Acute Bouts of Exercise in Adults: A Systematic Review

et al. 2021

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The purpose of the study was to systematically review the evidence on the effects of an acute bout of exercise on concurrent performance of core executive function (EF) during exercise in adults. Four electronic databases (i.e., PubMed, Web of Science, PsycINFO, and SportDiscus) were searched from inception dates to 30 December 2020. The literature searches were conducted using the combinations of two groups of relevant items related to exercise and executive function. Articles were limited to human studies in adults. The search process, study selection, data extraction, and study quality assessments were carried out independently by two researchers. A total of 4899 studies were identified. Twenty-two studies met our inclusion criteria. Of the 42 reported outcomes in the 22 studies, 13 (31%) of the 42 outcomes showed that core EF performance was enhanced during exercise and 14 (33%) found that core EF performance did not differ from control conditions. Fifteen (36%) found that core EF performance was impaired. Notably, improved EF performances tend to be observed during moderate-intensity exercise, whereas impaired EF performances were more likely to be observed at vigorous-high intensity. The review suggests mixed findings regarding the effects of an acute bout of exercise on concurrent performance of core EF. Exercise intensity seems to influence the effects. The underlying neural mechanisms remain to be elucidated.

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Section: Facilitation No Effect Impairmentmentioning

confidence: 98%

Section: Study Findingsmentioning

confidence: 98%

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Concurrent Performance of Executive Function during Acute Bouts of Exercise in Adults: A Systematic Review

et al. 2021

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“…The search methods resulted in 67 articles. After removal of duplicates, 15 [45,46,50,53,[60][61][62][63][64][65][66][67][68][69] articles were identified in PubMed and 5 [47,51,[70][71][72] new articles in CINAHL. During the initial screening of titles/abstracts, 11 articles were excluded due to HIIE not being the primary experimental protocol performed (n = 6), studies not measuring cerebral arteries (n = 4) and an animal study (n = 1).…”

Section: Resultsmentioning

confidence: 99%

Effects of high intensity interval exercise on cerebrovascular function: A systematic review

et al. 2020

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High intensity interval exercise (HIIE) improves aerobic fitness with decreased exercise time compared to moderate continuous exercise. A gap in knowledge exists regarding the effects of HIIE on cerebrovascular function such as cerebral blood velocity and autoregulation. The objective of this systematic review was to ascertain the effect of HIIE on cerebrovascular function in healthy individuals. We searched PubMed and the Cumulative Index to Nursing and Allied Health Literature databases with apriori key words. We followed the Preferred Reporting Items for Systematic Reviews. Twenty articles were screened and thirteen articles were excluded due to not meeting the apriori inclusion criteria. Seven articles were reviewed via the modified Sackett’s quality evaluation. Outcomes included middle cerebral artery blood velocity (MCAv) (n = 4), dynamic cerebral autoregulation (dCA) (n = 2), cerebral de/oxygenated hemoglobin (n = 2), cerebrovascular reactivity to carbon dioxide (CO 2 ) (n = 2) and cerebrovascular conductance/resistance index (n = 1). Quality review was moderate with 3/7 to 5/7 quality criteria met. HIIE acutely lowered exercise MCAv compared to moderate intensity. HIIE decreased dCA phase following acute and chronic exercise compared to rest. HIIE acutely increased de/oxygenated hemoglobin compared to rest. HIIE acutely decreased cerebrovascular reactivity to higher CO 2 compared to rest and moderate intensity. The acute and chronic effects of HIIE on cerebrovascular function vary depending on the outcomes measured. Therefore, future research is needed to confirm the effects of HIIE on cerebrovascular function in healthy individuals and better understand the effects in individuals with chronic conditions. In order to conduct rigorous systematic reviews in the future, we recommend assessing MCAv, dCA and CO 2 reactivity during and post HIIE.

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“…The competition between different brain regions for limited metabolic resources would occur in VPA, and more metabolic resources were allocated to motor and sensory cortices when VPA was performed at the expense of metabolic resources supplied to the prefrontal cortex (29). VPA impairs metabolism in the prefrontal cortex of the brain in patients with heart disease and ultimately cognitive performance (30,31). Cerebral blood ow is increased by the activation of local neurons to meet metabolic demand (32), during exercise, cerebral blood ow is regulated by a complex interplay between neuronal activity and metabolism, blood pressure, sympathetic nervous system activity, partial pressure of oxygen and carbon dioxide, and cardiac output (33,34).…”

Section: Discussionmentioning

confidence: 99%

Associations Between Physical Activity and Cognitive Function, Daily Physical Function in Chinese With Heart Disease: A Cross-Sectional Study

Ding¹,

Jia²,

Zhou³

et al. 2021

Preprint

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Background: To investigate the associations between different dimensions (intensity, frequency, duration, volume, metabolic equivalent) of physical activity (PA) and cognitive function, daily physical function in Chinese with heart disease. Methods: This study included 2792 individuals from the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2015. PA was divided into vigorous PA (VPA), moderate PA (MPA), and light PA (LPA). Linear regression models and binary logistic regression models were established to assess the associations be-tween indicators respectively. Results: Compared with taking no PA, MPA and VPA with a frequency of 6-7 d/w had lower risks of impaired daily physical function (OR=0.47, 95%CI: 0.25, 0.91; OR= 0.57, 95%CI: 0.37, 0.88) and higher cognitive function scores (β=1.22, 95%CI: 0.42, 2.03; β=1.08, 95%CI: 0.43, 1.73), while VPA of 3-5 d/w had lower cognitive function scores (β=-1.96, 95%CI: -3.51, -0.40). LPA with a duration of 30-119 min/d had lower risks of impaired daily physical function (OR=0.59, 95%CI: 0.36, 0.97). MPA and VPA of 30-119 min/d had higher cognitive function scores (β=1.43, 95%CI: 0.49, 2.37; β=1.30, 95%CI: -0.56, 2.06). Lower cognitive function scores in volume of ≥ 300 min/w. (β=-1.18, 95%CI: -2.14, -0.23). 1800-8999 METs had lower risks of impaired daily physical function and higher cognitive function scores. 1800-2999 METs had lowest risks of impaired daily physical function and highest cognitive function scores. (OR=0.18, 95%CI: 0.04, 0.75; β=2.94, 95%CI: 1.67, 4.21). Conclusions: This study found that VPA are associated with lower cognition, MPA and LPA are beneficial to cognition and daily physical function.Trial registration: IRB00001052-11015.

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Cognitive Impairment during High-Intensity Exercise: Influence of Cerebral Blood Flow

Cited by 23 publications

References 38 publications

Concurrent Performance of Executive Function during Acute Bouts of Exercise in Adults: A Systematic Review

Concurrent Performance of Executive Function during Acute Bouts of Exercise in Adults: A Systematic Review

Effects of high intensity interval exercise on cerebrovascular function: A systematic review

Associations Between Physical Activity and Cognitive Function, Daily Physical Function in Chinese With Heart Disease: A Cross-Sectional Study

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