Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients

Wu, Lisa M.; Amidi, Ali

doi:10.1097/spc.0000000000000251

Cited by 37 publications

(14 citation statements)

References 69 publications

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“…With advances in treatments (e.g., chemotherapy, immunotherapies), BC survival rates have increased [ 2 , 3 ]; however, systemic chemotherapy can cause adverse reactions [ 3 ]. Although severe neurotoxic events are rare, risks of cognitive decline have varied in their estimates from 15~60% to the extent of interfering with the quality of everyday life [ 3 , 4 , 5 , 6 , 7 ]. Specifically, impairments in attention, concentration, learning, processing speed, and executive functioning have been reported [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cancer, Chemotherapy, and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Chen

Lin

Hsiao

et al. 2021

Cancers

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Background: We aimed to investigate the associations of breast cancer (BC) and cancer-related chemotherapies with cytokine levels, and cognitive function. Methods: We evaluated subjective and objective cognitive function in BC patients before chemotherapy and 3~9 months after the completion of chemotherapy. Healthy volunteers without cancer were also compared as control group. Interleukins (IL) 2, 4, 5, 6, 10, 12p70, 13, 17A, 1β, IFNγ, and TNFα were measured. Associations of cancer status, chemotherapy and cytokine levels with subjective and objective cognitive impairments were analyzed using a regression model, adjusting for covariates, including IQ and psychological distress. Results: After adjustment, poorer performance in semantic verbal fluency was found in the post-chemotherapy subgroup compared to controls (p = 0.011, η2 = 0.070); whereas pre-chemotherapy patients scored higher in subjective cognitive perception. Higher IL-13 was associated with lower semantic verbal fluency in the post-chemotherapy subgroup. Higher IL-10 was associated with better perceived cognitive abilities in the pre-chemotherapy and control groups; while IL-5 and IL-13 were associated with lower perceived cognitive abilities in pre-chemotherapy and control groups. Our findings from mediation analysis further suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Conclusions: Our findings suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Different cytokines and their interactions may have different roles of neuroinflammation or neuroprotection that need further research.

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Section: Introductionmentioning

confidence: 99%

Effects of Cancer, Chemotherapy, and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Chen

Lin

Hsiao

et al. 2021

Cancers

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“…Less is known about the changes in cognitive function associated with AI therapy because few studies have focused on cognitive function with these agents. In addition, methodologic issues reduce the ability to compare results across studies (Wu & Amidi, 2017). Samples in some studies were heterogeneous, combining premenopausal with postmenopausal women (Ganz et al, 2014; Hermelink et al, 2008; Jenkins et al, 2006; Palmer et al, 2008) and women who received AIs with women who received SERMs (Collins, Mackenzie, Stewart, Bielajew, & Verma, 2009; Ganz et al, 2014; Mar Fan et al, 2007; Root, Andreotti, Tsu, Ellmore, & Ahles, 2016; Schilder et al, 2009).…”

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confidence: 99%

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Bender¹,

Merriman²,

Sereika³

et al. 2018

ONF

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OBJECTIVES This study identified women with unique trajectories of executive function, concentration, and visual working memory before and during adjuvant therapy for breast cancer, and examined phenotypic and genotypic predictors associated with subgroups. SAMPLE & SETTING 399 postmenopausal women, of whom 288 were women with early-stage breast cancer and 111 were women without breast cancer, matched on age and years of education to the women with breast cancer, and all at an urban cancer center. METHODS & VARIABLES A repeated-measures design was used; assessments occurred before adjuvant therapy and every six months post-therapy initiation. Group-based trajectory modeling determined subgroups. Multinomial logistic regression identified phenotypic and genotypic characteristics. RESULTS Three executive function and concentration trajectory subgroups were identified: low, moderate, and high; two visual working memory subgroups were identified: low and high. IMPLICATIONS FOR NURSING Advancing age, greater pretherapy fatigue, and poorer pretherapy cognitive function are associated with the low subgroups. DNA repair and oxidative stress mechanisms may be involved in the cognitive changes that women experience.

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“…On the other, it has been suggested that chemotherapy and hormone therapy produce cognitive deficits (Dietrich & Kaiser, 2016; Wu & Amidi, 2017). One of the cognitive domains most referenced in this field is that of the executive functions (Vitali et al, 2017; Yao, Bernstein & Rich, 2017).…”

Section: Discussionmentioning

confidence: 99%

Functioning of autobiographical memory specificity and self-defining memories in people with cancer diagnosis

Nieto

Bravo

Moreno

et al. 2019

PeerJ

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ObjectivesCognitive and emotional disturbances have been associated with the diagnosis and treatment of cancer. Autobiographical memory is one of the specific cognitive processes affected during this disease. The current study had two main aims: (1) to compare the functioning of autobiographical memory specificity and its related variables (executive functioning, depression and perceived stress) in a group of persons with cancer and a control group; and (2) to analyze whether the experience of cancer evolved into a self-defining memory in the sample of participants diagnosed with this disease.MethodThe study sample comprised 62 participants, 31 in the group with a cancer diagnosis and 31 in the control group. Autobiographical memory specificity, executive functions, depression, stress and self-defining memory were evaluated in the current study.ResultsDepressive symptomatology and reduced executive functioning, but not perceived stress levels, are related and are predictors of autobiographical memory specificity. In addition, the identified characteristics of the self-defining memories were associated with the cancer experience as a threat to physical integrity and an awareness of the meaning of life.ConclusionThis emerging research line is especially important in view of its possible impacts on patients’ well-being, due to the importance of psychological processes in cancer disease.

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Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients

Cited by 37 publications

References 69 publications

Effects of Cancer, Chemotherapy, and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Effects of Cancer, Chemotherapy, and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Trajectories of Cognitive Function and Associated Phenotypic and Genotypic Factors in Breast Cancer

Functioning of autobiographical memory specificity and self-defining memories in people with cancer diagnosis

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