Cognitive impairment in Behçet's disease patients without overt neurological involvement

Monastero, Roberto; Camarda, Cecilia; Pipia, Carmela; Lopez, Gianluca; Camarda, Lawrence; Baiamonte, Valentina; Ferrante, A; Triolo, G; Camarda, Rosolino

doi:10.1016/j.jns.2004.02.021

Cited by 67 publications

(47 citation statements)

References 25 publications

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“…4,5 It has been suggested that psychiatric symptoms observed in BD are related to the corticosteroid treatment rather than an organic cause. 6,7 Some researchers have claimed that psychiatric symptoms can be related with NBD and can occur even 8 years after the diagnosis of NBD. They have classified these symptoms according to the severity of behavioral pathology.…”

Section: Introductionmentioning

confidence: 99%

“…As far as the authors know, there is only one recent study encountered in the literature on NPT performance in the non-NBD form of BD emphasizing the relation between lower test performance and the use of steroid treatment. 7 The executive functions which are related with frontal lobe activities 14 is the term used for describing cognitive processes related with high level thinking like cognitive flexibility in changing answers according to the conditions, making decisions and planning, taking action. 15 These functions are evaluated by several tests.…”

Section: Introductionmentioning

confidence: 99%

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Executive dysfunctions and depression in Behçet’s disease without explicit neurological involvement

Erberk-Özen¹,

Bırol

Boratav³

et al. 2006

Psychiatry Clin Neurosci

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This study aims to assess the executive functions and depression status in patients with Behçet's disease without explicit neurological involvement and to evaluate cognitive functions in this group of patients independent of accompanying depression. In the present study, 30 patients with Behçet's disease in the non-active phase of their illness and 30 healthy volunteers were included. In the evaluation of depression levels, Beck Depression Inventory was employed. The executive functions of the patients were evaluated by Wisconsin Card Sorting Test (WCST) and Stroop Test (ST). Beck Depression Inventory scores measured in the Behçet's disease group, in which no clinically serious depression was observed, were higher than the control group. Then, it was observed that the scores of neuropsychological tests of the Behçet's disease group were found to be significantly lower, especially in WCST, while significant relations were revealed between Beck Depression Inventory scores and WCST, ST scores. The authors' findings suggest that there may be factors other than depression causing executive impairment in patients with Behçet's disease without explicit neurological symptoms. Executive dysfunctions may occur in association with mild depressive states due to chronic disease stress or silent and/or future neurological involvement of Behçet's disease, especially in the frontal lobes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Executive dysfunctions and depression in Behçet’s disease without explicit neurological involvement

Erberk-Özen¹,

Bırol

Boratav³

et al. 2006

Psychiatry Clin Neurosci

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“…Another engaging theory suggests that it could be related to the frequent observation of psychiatric symptoms during relapses or, in some cases, in the phases preceding reactivation of the disease; these elements suggest that psychiatric disorders in BS could represent a crucial element, whether a psychiatric subset or a distinct clinical feature of the disease. Moreover, it has been reported that cognitive impairment in BS can be seen with or without CNS involvement [19]. Globally, psychiatric symptoms have been described as multifaceted, ranging from anxiety disorders to depressive-bipolar disorders or to psychotic ones.…”

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confidence: 99%

Epidemiology and Management of Neuropsychiatric Disorders in Behçet’s Syndrome

et al. 2015

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Behçet's syndrome (BS) is a systemic, chronic, relapsing vasculitis, typically characterized by recurrent orogenital ulcers, ocular inflammation and skin manifestations; articular, vascular, gastroenteric and neurological involvement may also occur. Besides the other clinical features of BS, it seems relatively frequent that patients with BS develop a neurobehavioural syndrome, characterized by euphoria, bipolar disorders and paranoid attitudes, loss of insight/disinhibition, and indifference to their disease, defined as 'neuro-psycho-BS'. To date, the pathogenetic mechanism underlying neuro-psycho-BS has not been determined. It may be secondary to organic neurological involvement, or it may be related to poor quality of life and the relapsing course of the disease. Another engaging theory suggests that it could be related to the frequent observation of psychiatric symptoms during relapses or, in some cases, in the phases preceding reactivation of the disease; these elements suggest that psychiatric disorders in BS could represent a crucial element, whether a psychiatric subset or a distinct clinical feature of the disease. Moreover, it has been reported that cognitive impairment in BS can be seen with or without central nervous system involvement. Globally, psychiatric symptoms have been described as being multifaceted, ranging from anxiety disorders to depressive-bipolar disorders or to psychotic ones. In addition, some psychological characteristics of BS patients seem to predispose them to maladaptive stress management, which may lead to stress-related disorders, including anxiety and depression. Therefore, the aims of this review are to explore the epidemiology of neuro-psycho-BS by evaluating the relationship between the stress system and the multifaceted psychiatric manifestations in BS, and to summarize the therapeutic strategy used.

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“…It has also known that the prevalence of depression and anxiety is higher in BD patients than healthy people (Calikoglu et al, 2001;Monastero et al, 2004;Taner et al, 2007).…”

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confidence: 99%