Cognitive impairment in carriers of glucocerebrosidase gene mutation in Parkinson disease patients

Abstract

The N370S GBA mutation is the risk factor for cognitive impairment in PD patients.

Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease

“…In cross-sectional analyses of GBA mutations in PD patients, earlier disease onset, increased cognitive impairment, a greater family history of PD, and more frequent pain were reported in patients with mutations, compared with no mutations (Chahine et al, 2013;Clark et al, 2007;Gan-Or et al, 2008;Kresojevic et al, 2015;Lwin et al, 2004;Malec-Litwinowicz et al, 2014;Mitsui et al, 2009;Neumann et al, 2009;Nichols et al, 2009;Seto-Salvia et al, 2012;Sidransky et al, 2009;Swan and SaundersPullman, 2013;Wang et al, 2012). Recently, a few prospective studies have investigated clinical features of PD with GBA and showed a more rapid progression of motor impairment and cognitive decline in GBA mutation cases than in PD controls (Beavan et al, 2015;Brockmann et al, 2015;Winder-Rhodes et al, 2013).…”

Olfaction deterioration in cognitive disorders in the elderly

“…PD etiology is largely unknown, although some authors have suggested the nasal entry of viruses, such as herpes simplex virus type 1 (HSV1), as a possible cause of the disease [34]. Genetic factors, such as glucocerebrosidase gene mutation, are also involved with a variable prevalence of up to 19 % [35]. Other possible causes of the disease could be epithelial or bulbar damage initiated by exposure to airborne environmental toxins or focal head trauma [12].…”

The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

“…Neurodegeneration is the umbrella term covering the progressive loss of neuronal structure or function, resulting in irreversible brain damage. The incidence of NDDs, including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), is increasing at an alarming rate worldwide [1,8,9]. However, the etiologies of NDDs are not well understood.…”