Cognitive impairment in chronic migraine: a cross-sectional study in a clinic-based sample

Latysheva, N. V.; Филатова, Е. Г.; Osipova, Darya; Danilov, А B

doi:10.1590/0004-282x20190159

Cited by 23 publications

(33 citation statements)

References 33 publications

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“…It was found that the severity of memory decline is related to migraine frequency and duration [ 16 ]. A similar hypothesis was seen in several other articles [ 17 - 19 ]. Some studies found a discordant result of the migraine and dementia link [ 20 - 21 ].…”

Section: Reviewsupporting

confidence: 90%

Headache - A Window to Dementia: An Unexpected Twist

Sharif¹,

Saleem²,

Koumadoraki³

et al. 2021

Cureus

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Migraine and other types of headaches have several symptoms associated with them. The association between migraine and dementia has been considered. It is a topic of discussion and appears to be multifactorial. Dementia is a cluster of symptoms, with memory loss and cognitive dysfunction being the prominent symptoms. In this review, we discussed the association of headache and cognitive dysfunction in a broader context and how the practiced treatment of headaches may silently lead to dementia. We conducted a thorough literature search using PubMed as our main database. The articles exploring the association between headache (both migraine and non-migraine) and dementia were included. Some risk factors like migraine-induced stroke and inherent vascular diseases in migraine patients channeling to stroke and dementia were not considered. A total of 28 studies were included for review. All the reviewed studies put together showed an association between headache and cognitive dysfunction of any form. They showed that the frequency and duration of headache is a determinant for dementia. Few studies also focused on how treating headaches with certain drugs can lead to dementia. The reviewed published literature showed that headaches of any sort and their treatment are potentially linked to dementia. Not all headache patients will require medical treatment, as the benefit might outweigh the risk sometimes. It is interim to understand these facts and formulate a better protocol for treating headache patients. However, due to some discordant results, further studies are needed.

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Section: Reviewsupporting

confidence: 90%

Headache - A Window to Dementia: An Unexpected Twist

Sharif¹,

Saleem²,

Koumadoraki³

et al. 2021

Cureus

View full text Add to dashboard Cite

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“…From the 15,316 records identified by the search methods, 37 studies (Demirci and Savas, 2002 ; Weiner et al, 2006 ; Meeks et al, 2008 ; Shega et al, 2010 , 2012 ; Jonsson et al, 2011 ; Walteros et al, 2011 ; Ko et al, 2013 ; Pirrotta et al, 2013 ; Butterworth et al, 2014 ; Docking et al, 2014 ; Hagen et al, 2014 ; Martinsen et al, 2014 ; Pickering et al, 2014 ; Coppieters et al, 2015 ; Meeus et al, 2015 ; Öncü et al, 2015 ; Dos Santos Ferreira et al, 2016 ; Fernández-Lao et al, 2016 ; Santangelo et al, 2016 ; Schepker et al, 2016 ; Kaiho et al, 2017 ; Tzeng et al, 2017 ; Whitlock et al, 2017 ; Jordan et al, 2018 ; Ojeda et al, 2018 ; Pidal-Miranda et al, 2018 ; Qu et al, 2018 ; Van Der Leeuw et al, 2018b , 2020 ; Veronese et al, 2018 ; Gu et al, 2019 ; Ikram et al, 2019 ; Samartin-Veiga et al, 2019 ; Kotb et al, 2020 ; Latysheva et al, 2020 ; Nakai et al, 2020 ) were identified, a total of 52,373 patients with CP and 80,434 healthy control participants. These 37 studies included different types of CP: headache ( n = 7); fibromyalgia syndrome (FM) ( n = 6); low back pain ( n = 3); whiplash-associated disorder ( n = 2); foot pain ( n = 2); cancer pain ( n = 1); low back pain and knee pain ( n = 1); neuropathic pain ( n = 1); musculoskeletal pain, neuropathic pain, and FM ( n = 1); post-herpetic neuralgia ( n = 1); non-cancer pain ( n = 1); and other unclassified CP ( n = 13).…”

Section: Resultsmentioning

confidence: 99%

Evidence for Cognitive Decline in Chronic Pain: A Systematic Review and Meta-Analysis

et al. 2021

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Background: People with chronic pain (CP) sometimes report impaired cognitive function, including a deficit of attention, memory, executive planning, and information processing. However, the association between CP and cognitive decline was still not clear. Our study aimed to assess the association of CP as a risk factor with cognitive decline among adults.Methods: We included data from clinical studies. Publications were identified using a systematic search strategy from PubMed, Embase, and Cochrane Library databases from inception to October 10, 2020. We used the mean cognitive outcome data and the standard deviations from each group. The standardized mean difference (SMD) or odds ratio (OR), and 95% confidence intervals (CI) were performed for each cognitive decline outcome. I2-values were assessed to quantify the heterogeneities.Results: We included 37 studies with a total of 52,373 patients with CP and 80,434 healthy control participants. Because these studies used different evaluative methods, we analyzed these studies. The results showed CP was associated with cognitive decline when the short-form 36 health survey questionnaire (SF-36) mental component summary (SMD = −1.50, 95% CI = −2.19 to −0.81), the Montreal cognitive assessment (SMD = −1.11, 95% CI = −1.60 to −0.61), performance validity testing (SMD = 3.05, 95% CI = 1.74 to 4.37), or operation span (SMD = −1.83, 95% CI = −2.98 to −0.68) were used. However, we got opposite results when the studies using International Classification of Diseases and Related Health Problems classification (OR = 1.58, 95% CI = 0.97 to 2.56), the Mini-Mental State Examination (SMD = −0.42, 95% CI = −0.94 to 0.10; OR = 1.14, 95% CI = 0.91 to 1.42), and Repeatable Battery for the Assessment of Neuropsychological Status memory component (SMD = −0.06, 95% CI = −0.37 to 0.25).Conclusion: There may be an association between CP and the incidence of cognitive decline when some cognitive, evaluative methods were used, such as short-form 36 health survey questionnaire, Montreal cognitive assessment, performance validity testing, and operation span.

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“…migraine chronification or medication overuse. Compared with episodic migraine, individuals with chronic migraine are observed to have more cognitive impairment [41]. Furthermore, a review found that individuals with complicated medication overuse headache (MOH) have better outcomes after inpatient treatment indicating that cases of MOH may be inclined to seek hospital treatment [42].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study

et al. 2020

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Background: Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all prevalent dementia subtypes. The main objective of this national register-based study was to investigate whether migraine was a risk factor for dementia. Additionally, we explored potential differences in dementia risk for migraine with and without aura. Methods: We obtained data on birth cohorts born between 1935 and 1956 (n = 1,657,890) from Danish national registers. Individuals registered with migraine before age 59 (n = 18,135) were matched (1:5) on sex and birthdate with individuals without migraine (n = 1,378,346). Migraine was defined by International Classification of Diseases (ICD) diagnoses and dementia was defined by ICD diagnoses and anti-dementia medication. After matching, 62,578 individuals were eligible for analysis. For the statistical analyses, we used Cox regression models and adjusted for socio-demographic factors and several psychiatric and somatic morbidities. Results: During a median follow-up time of 6.9 (IQR: 3.6-11.2) years, 207 individuals with migraine developed dementia. Compared with individuals without migraine, we found a 50% higher rate of dementia among individuals with migraine (HR = 1.50; 95% CI: 1.28-1.76). Individuals without aura had a 19% higher rate of dementia (HR = 1.19; 95% CI: 0.84-1.70), and individuals with aura had a two times higher rate of dementia (HR = 2.11; 95% CI: 1.48-3.00). Conclusions: Our findings support the hypothesis that migraine is a midlife risk factor for dementia in later life. The higher rate of dementia in individuals with a hospital-based diagnosis of migraine with aura emphasizes the need for studies on pathological mechanisms and potential preventative measures. Furthermore, given that only hospitalbased migraine diagnoses were included in this study, future research should also investigate migraine cases derived from the primary healthcare system to include less severe migraine cases.

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Cognitive impairment in chronic migraine: a cross-sectional study in a clinic-based sample

Cited by 23 publications

References 33 publications

Headache - A Window to Dementia: An Unexpected Twist

Headache - A Window to Dementia: An Unexpected Twist

Evidence for Cognitive Decline in Chronic Pain: A Systematic Review and Meta-Analysis

Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study

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