Cognitive impairment in depression and potential applications of antidepressants with procognitive effects

Бобров, А. Е.; Краснослободцева, Лариса Алексеевна; Mutnykh, Elena; Курсаков, А А

doi:10.17116/jnevro201411411210-14

Cited by 6 publications

(2 citation statements)

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“…The presence of an inverse correlation between VAS values and cough monitoring device data indicates that in patients with COPD and anxiety/depression, critical thinking and assessment of their condition, in particular, of cough, is impaired. It is known that depression leads to a so-called “depressive shift” that affects the sphere of attention, thinking, memory, and prediction and it makes an assessment of a physical condition more difficult [28]. The analysis and synthesis of information is disturbed, one-sided, and incomplete, and negative and pessimistic views take over.…”

Section: Discussionmentioning

confidence: 99%

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

et al. 2019

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Background and objectives: Obesity and anxiety and/or depression are common comorbidities in patients with chronic obstructive pulmonary disease (COPD). For doctors treating COPD, cough has a certain importance as a symptom. The purpose of this study was to figure out how obesity and anxiety/depression may influence the subjective assessment of cough. Materials and Methods: 110 patients with COPD participated in the study. The patients were divided into two groups, one including obese patients, and the other including patients with normal body weight. All patients filled out the hospital anxiety and depression scale (HADS) questionnaire, evaluated the severity of their cough by using visual analogue scale (VAS) on the 1st and 10th day of treatment, and underwent a 12 h cough monitoring with a special cough monitoring device both on the 1st and the 10th day of treatment. Results: The severity of anxiety according to the HADS in patients with COPD and normal body weight was significantly higher than in patients with COPD and obesity, corresponding to 9.25 ± 1.37 and 8.20 ± 1.18 points, respectively (p = 0.0063). The patients with normal body weight and obesity, but without anxiety and depression, subjectively noted an improvement in their well-being on the 10th day of treatment (p = 0.0022, p = 0.0021, respectively). In subgroups with normal body weight and obesity with anxiety and/or depression, the mean values for VAS on day 10 did not change significantly (p = 0.1917, p = 0.1921, respectively). Also, patients from the subgroup with normal body weight and anxiety/depression had a significantly higher assessment of their cough on day 10 than obese patients with anxiety/depression (p = 0.0411). The VAS values correlated positively with the actual amount of cough (r = 0.42, p = 0.0122 and r = 0.44, p = 0.0054, respectively) in patients without anxiety and/or depression, while in patients with anxiety and/or depression, there was an inverse correlation between VAS values and cough (r = −0.38, p = 0.0034 and r = −0.40, p = 0.0231). Conclusions: It is important to diagnose and treat anxiety and depression in patients with COPD for a better prognosis and higher efficacy of medical treatments. While treating such patients, it is preferable to use a cough monitoring device for objective assessments, since the patients may exaggerate or underestimate their symptoms.

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Section: Discussionmentioning

confidence: 99%

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

et al. 2019

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“…Determination of sample size was based on the primary endpoint, namely the incongruent reading speed in the Stroop Color and Word Test. From our previous work [29], it is known that the standard deviation of this parameter is 5.94 s and that the minimum clinically significant difference in the test is 5 s. From this, specifying a significance level of 5% and a statistical power of 80% in a two-tailed test, a minimum per-protocol sample size estimate of 35 was derived. This was increased to 43 to reflect the fact that the outcome variable does not follow a normal distribution and the overall sample size for the intention-to-treat population was set to 50 subjects.…”

Section: Statistical Considerationsmentioning

confidence: 99%

Effects of Fluvoxamine on Cognitive Function in Outpatients with Depression in Remission: Results of an Open-Label Pilot Study

Бобров¹,

Краснослободцева²,

Mutnykh³

2017

J Psychiatry

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A prospective, non-comparative, single-centre, single-group study was conducted in 50 adult patients with currently remitted recurrent depressive disorder according to the criteria of the International Classification of Diseases, 10th revision in order to assess changes in cognitive function during preventive therapy with fluvoxamine. Responses to therapy were evaluated using the Stroop Color and Word Test as the primary efficacy outcome. The revised Addenbrooke's Cognitive Examination, Frontal Assessment Battery, Hamilton Rating Scale for Depression and Social Adaptation Self-evaluation Scale were used as secondary indices. Fluvoxamine was administered at doses of 50-150 mg/day for 24 weeks. Fluvoxamine therapy was associated with a range of 'pro-cognitive' responses that resulted in improvement in executive functions, including improved voluntary regulation of inhibitory control and restoration of verbal fluency. No dose relation was apparent for these effects. The incidence of treatmentrelated adverse events was low and no serious or severe events were recorded. These findings indicate that further studies of fluvoxamine are warranted and feasible to characterize possible beneficial effects on cognitive processes in patients with depression.

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Characteristics of Executive Functions in Patients With Cognitive Impairments in the Presence of Depressive Disorders

Yaroslavtsev¹

2020

Lʹviv. klin. visn.

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Introduction. The urgency of the problem of affective pathology and, above all, depression, due to a number of factors: the growing prevalence of depression, reaching 10.0 % in the population, the high risk of chronic such conditions, their maladaptive impact on social functioning, efficiency and quality of life, the burden of economic costs etc. According to epidemiological indicators in Ukraine over the past 10 years, the incidence of affective disorders has increased by 6.13 %, and the prevalence – by 13.16 %. Impaired thinking and executive functions, decreased concentration and difficulty making decisions are key diagnostic signs of depression. Cognitive impairment (CI) has a cumulative effect on the functionality of patients with depression and is associated with a longer duration of depressive episodes, which indicates the need for its diagnosis and treatment. At the present stage, there are no systematic ideas about the specifics of disorders of executive functions in the presence of different types of depressive disorders (DD), which determines the relevance of the study in this direction. The aim of the study. Describe the executive functions in patients with CI in the presence of DD. Materials and methods. The study included 362 patients with CI in the presence of DD, which were stratified into three groups of comparisons by the mechanism of DD: 123 patients with recurrent depressive disorders (RDD), 141 patients with bipolar affective disorder (BAD) and 98 people with prolonged depressive reaction (PDR). The predominant numbers (38.12 %) of patients with CI in the presence of DD were in adulthood (30-44 years). There were more young people (18-29 years) among patients with PDR (21.43 %, DC = 8.19) and among patients with BAD (31.21 %, DC = 9.82), and middle-aged people (45-59 years) (37.40 %, DC = 1.54) and the elderly (60-74 years) (17.07 %, DC = 4.78) – among patients with RDD. A set of research methods was used: clinical-psychopathological, psychodiagnostic and statistical. Results. Peculiarities of executive functions in patients with CI in the presence of DD were established: the moderate and severe disorders of visual-motor coordination (39.84 % and 19.51 %, respectively) and impaired visual-spatial functions (13.72 %), moderate and severe violations of executive functions (54.47 % and 13.01 %, respectively), moderate, severe and weak violations of the executive function of the lexical system (39.84 %, 32.52 % and 23.58 %, respectively) were present in patients with RDD; the moderate violations of verbal performance (58.54 %); moderate and severe violations of visual-motor coordination (41.13 % and 26.24 %, respectively), executive functions (65.96 % и 21.38 %, respectively), executive functions of the lexical system (47.52 % и 39,01 %, respectively) and verbal productivity (58.16 % and 21.28 % respectively) were found in BAD; absence and weak impairments of visual-motor coordination (45.92 % and 36.73 %, respectively), executive functions (23.47 % and 66.33 %, respectively), executive functions of the lexical system (31.63 % and 45.92 %, respectively) and verbal productivity (26.53 % and 58.16 %, respectively) were presented in patients with PDR. Conclusions. The study revealed the features of executive functions in patients with cognitive impairment in the presence of depressive disorders, which should be taken into account in the algorithm of their psychosocial rehabilitation.

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Cognitive impairment in depression and potential applications of antidepressants with procognitive effects

Cited by 6 publications

References 50 publications

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

Effects of Fluvoxamine on Cognitive Function in Outpatients with Depression in Remission: Results of an Open-Label Pilot Study

Characteristics of Executive Functions in Patients With Cognitive Impairments in the Presence of Depressive Disorders

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