Cognitive impairment in different MS subtypes and clinically isolated syndromes

Potagas, Constantin; Giogkaraki, Erasmia; Koutsis, Georgios; Mandellos, D.; Tsirempolou, Erifylli; Sfagos, Constantinos; Vassilopoulos, D.

doi:10.1016/j.jns.2007.10.002

Cited by 216 publications

(157 citation statements)

References 29 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Studies on large MS patient samples have shown that the range of cognitive impairment prevalence in MS is between 40 and 70% and appears in all stages and types of the disease (which also includes the clinically isolated syndrome-CIS) [21]. It seems that observations carried out for long enough are able to show cognitive impairment in progressive stages [22].…”

Section: The Course Of Cognitive Deficitmentioning

confidence: 99%

Cognitive Deficits and Neuropsychological Assessment in Multiple Sclerosis

Javůrková¹,

Zimová²,

Tomašovičová³

et al. 2016

Trending Topics in Multiple Sclerosis

View full text Add to dashboard Cite

The aim of this chapter was to introduce the contents of neuropsychological assessment in multiple sclerosis, which should include the functional evaluation of cognitive domains, the psychopathology of personality, levels of depression, and the assessment of psychosocial aspects and quality of life with multiple sclerosis. Further, the most commonly used neuropsychological diagnostics are described. The chapter hopes to draw attention to the importance of neuropsychological assessment which should be a part of neurological diagnostics and therapy, including rehabilitation and psychotherapy.

show abstract

Section: The Course Of Cognitive Deficitmentioning

confidence: 99%

Cognitive Deficits and Neuropsychological Assessment in Multiple Sclerosis

Javůrková¹,

Zimová²,

Tomašovičová³

et al. 2016

Trending Topics in Multiple Sclerosis

View full text Add to dashboard Cite

show abstract

“…In a relative short period of testing, the main cognitive domains can be assessed and performances can be compared over a time frame. BRB-N has been normalized and used in Germany 20 , the USA [21][22][23] , Italy 15,24,25 , Spain 26,27 , the Netherlands 28,29 , Israel 30 , Greece 31 , and the United Kingdom 32 . In France, an adapted version of BRB-N has been proposed 33 .…”

Section: Brb-n Is a Neuropsychological Screening Battery Of Tests Thamentioning

confidence: 99%

Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

Brooks

Borela²,

Fragoso

2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

To assess the cognition of patients with multiple sclerosis (MS) using the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRB-N). Method: BRB-N was translated and adapted for control subjects. Subsequently, it was applied to a group of patients with relapsing-remitting (RR) MS. Results: The assessment on the healthy controls (n=47) showed that the correlation between tests on the same cognitive domain was high and that there was a five-factor solution that explained 90% of the total variance. Except for the Word List Generation subset of tests, the performance of patients with RRMS (n=39) was worse than that of the healthy controls. Conclusion: BRB-N is a relatively simple method to assess cognition of patients with MS in the daily clinic. It does not take long to apply and does not require special skills or equipment. Key words: multiple sclerosis, cognition, memory, neuropsychology.Avaliação da cognição usando a Bateria Breve de Testes Neuropsicológicos de Rao para pacientes brasileiros com esclerose múltipla RESUMO Avaliar a cognição de pacientes com esclerose múltipla (EM), utilizando a Bateria Breve de Testes Neuropsicológicos de Rao (BRB-N). Método: BRB-N foi traduzida e adaptada para controles. Subsequentemente, foi aplicada em um grupo de pacientes portadores de EM RR. Resultados: A avaliação de controles saudáveis (n=47) mostrou que a correlação entre os testes de um mesmo domínio cognitivo era alta e que uma solução de fator cinco explicava 90% da variação total. Exceto pela Lista de Palavras, o desempenho dos pacientes com EMRR (n=39) foi pior que aquele dos controles saudáveis. Conclusão: BRB-N é um método relativamente simples de avaliar cognição de pacientes com EM na prática clínica. O teste não requer muito tempo e não necessita de treinamento ou equipamentos especiais. Palavras-Chave: esclerose múltipla, cognição, memória, neuropsicologia.

show abstract

“…However, relatively little is known about the prevalence of cognitive impairment at the onset of the disease in CIS patients. Recent studies in this clinical population have described the presence of cognitive deficits ranging from mild to moderate, depending on the criteria used to define such an impairment [3,4,5,6].…”

mentioning

confidence: 99%

Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study

et al. 2011

View full text Add to dashboard Cite

Abstract:Objective. To assess whether abnormalities on functional magnetic resonance imaging (fMRI) are related to cognitive function in patients at presentation with clinically isolated syndrome (CIS) suggestive of MS. Methods. Eighteen CIS patients and 15 healthy controls (HC) performed an adapted fMRI version of the Paced Auditory Serial http://mc.manuscriptcentral.com/multiple-sclerosis Multiple Sclerosis Journal F o r P e e r R e v i e w Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (< 1SD from the mean value of HC) were considered "cognitive impairment" (CI); 8 patients were defined as "cognitively preserved" (CP). Between-group differences in the patterns of brain activations and effective connectivity were assessed. Results. During PASAT, compared to HC, CIS patients showed increased activations of the bilateral inferior parietal lobe (IPL), bilateral precuneus, bilateral middle frontal gyrus (MFG), left anterior cingulate cortex (ACC), left claustrum, right thalamus and right caudate nucleus. When CIS patients were analyzed, the CI group had a more significant activation of the bilateral IPL than HC and CP patients. Compared to CP patients, they also had more significant recruitment of the right superior parietal lobe, right cerebellum, left MFG and left ACC. The analysis of effective connectivity showed stronger connections between several regions of the right hemisphere involved in working memory function in CI patients vs. CP and HC. Conclusions. The observed differences in the patterns of cortical recruitment and connectivity in CI patients during PASAT performance are likely to be adaptive and have a role in limiting cognitive dysfunctions early in the course of MS. Methods. Eighteen CIS patients and 15 healthy controls (HC) performed an adapted fMRI version of the Paced Auditory Serial Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (< 1SD from the mean value of HC) were considered "cognitive impairment"(CI); 8 patients were defined as "cognitively preserved" (CP). Between-group differences in the patterns of brain activations and effective connectivity were assessed. Conclusions. The observed differences in the patterns of cortical recruitment and connectivity in CI patients during PASAT performance are likely to be adaptive and have a role in limiting cognitive dysfunctions early in the course of MS.

show abstract

Cognitive impairment in different MS subtypes and clinically isolated syndromes

Cited by 216 publications

References 29 publications

Cognitive Deficits and Neuropsychological Assessment in Multiple Sclerosis

Cognitive Deficits and Neuropsychological Assessment in Multiple Sclerosis

Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study

Contact Info

Product

Resources

About