Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis

Elias, Liana Rosa; Miskowiak, Kamilla; Vale, Antonio Maia Olsen do; Köhler, Cristiano A.; Kjærstad, Hanne Lie; Stubbs, Brendon; Kessing, Lars Vedel; Vieta, Eduard; Maes, Michaël; Goldstein, Benjamin I.; Carvalho, André F.

doi:10.1016/j.jaac.2017.01.008

Cited by 79 publications

(43 citation statements)

References 77 publications

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“…28 In contrast, a subsequent meta-analysis focussing on studies of euthymic BD youth exclusively, found impairments only in the domains of verbal and visual memory/learning as well as working memory compared to healthy controls. 29 While memory deficits are consistent with that of euthymic adult BD samples, the absence of processing speed, reasoning and problem-solving, and attention/vigilance deficits that are commonly seen in euthymic BD adults suggests a less pervasive trait-like dysfunction in younger onset patients. Interestingly, the one study of longitudinal cognitive changes in PBD 30 found impairments in most cognitive domains in predominantly euthymic patients ranging in age between 9 and 14 years.…”

Section: Post-onset Cognitive Functioning In Paediatric First Epismentioning

confidence: 65%

“…An initial meta‐analysis of 12 studies of BD youth across several mood states showed widespread, medium effect size deficits in cognition generally, and in most individual domains . In contrast, a subsequent meta‐analysis focussing on studies of euthymic BD youth exclusively, found impairments only in the domains of verbal and visual memory/learning as well as working memory compared to healthy controls . While memory deficits are consistent with that of euthymic adult BD samples, the absence of processing speed, reasoning and problem‐solving, and attention/vigilance deficits that are commonly seen in euthymic BD adults suggests a less pervasive trait‐like dysfunction in younger onset patients.…”

Section: Trajectory Of Cognitive Functioning In Bdmentioning

confidence: 97%

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Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

et al. 2019

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Objectives Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. Methods This paper provides a critical overview of the literature concerning the trajectories and emerging correlates of cognitive functioning in BD. It is a narrative review in which we provide a qualitative synthesis of current evidence concerning clinical, molecular, neural and lifestyle correlates of cognitive impairment in BD across the lifespan (in premorbid, prodromal, early onset, post‐onset, elderly cohorts). Results There is emerging evidence of empirical links between cognitive impairment and an increased inflammatory state, brain structural abnormalities and reduced neuroprotection in BD. However, evidence regarding the progressive nature of cognitive impairment is mixed, since consensus between different cross‐sectional data is lacking and does not align to the outcomes of the limited longitudinal studies available. Increased recognition of cognitive heterogeneity in BD may help to explain some inconsistencies in the extant literature. Conclusions Large, longitudinally focussed studies of cognition and its covariation alongside biological and lifestyle factors are required to better define cognitive trajectories in BD, and eventually pave the way for the application of a precision medicine approach for individual patients in clinical practice.

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Section: Post-onset Cognitive Functioning In Paediatric First Epismentioning

confidence: 65%

Section: Trajectory Of Cognitive Functioning In Bdmentioning

confidence: 97%

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

et al. 2019

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“…The presence of cognitive impairments among subjects affected by Bipolar Disorder (BD) in comparison to healthy individuals has been attested by several studies (Mann-Wrobel et al, 2011), especially in executive functioning, attention, visual/motor processing speed, verbal memory and verbal learning (Torres et al, 2007;Van Der Werf-Eldering et al, 2011). Interestingly, neurocognitive deficits seem to represent a trait feature of BD since cognitive alterations have been detected during all phases of the illness (Cipriani et al, 2017;Martínez-Arán et al, 2000), even during euthymia (Bostock et al, 2017;Elias et al, 2017).…”

Section: Main Textmentioning

confidence: 99%

The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review

Mandolini

Lazzaretti

Pigoni

et al. 2019

Journal of Affective Disorders

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“…However, the effect of AD on early‐onset bipolar disorder is less known and current studies usually have the limitation of small sample sizes. In PBD patients, anxiety comorbidity explains some of the heterogeneity observed in attention and working memory . PBD patients with AD comorbidity have more severe impairment and are admitted to the hospital more often .…”

Section: Introductionmentioning

confidence: 99%

Anxiety disorders comorbidity in pediatric bipolar disorder: a meta‐analysis and meta‐regression study

Eser

Taskiran

Ertinmaz

et al. 2020

Acta Psychiatr Scand

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Objective Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta‐analysis and meta‐regression study about the comorbidity and covariates of AD and PBD. Method We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted. Results Thirty‐seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive–compulsive disorder (OCD) was 16.7%. Childhood‐onset studies reported higher GAD and SAD comorbidity, while adolescent‐onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders’ comorbidity with PBD differently. Conclusion Anxiety disorders are highly comorbid with PBD. Early‐onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.

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Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis

Cited by 79 publications

References 77 publications

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review

Anxiety disorders comorbidity in pediatric bipolar disorder: a meta‐analysis and meta‐regression study

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