Cognitive impairment in major depression

Marazziti, Donatella; Consoli, G.; Picchetti, Michela; Carlini, Marina; Faravelli, Luca

doi:10.1016/j.ejphar.2009.08.046

Cited by 383 publications

(267 citation statements)

References 43 publications

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“…For example, depression may impact mothers' motivation to obtain and prepare food due to decreased appetite, physical and cognitive fatigue, and feelings of being overwhelmed by the task. 35,61 Depression may also increase feelings of helplessness when being psychologically controlled by a partner, 61 leading mothers to be especially challenged in terms of finding, accessing, and asking for the support they need. Thus, the managerial capacity of the mothers may have been greatly challenged by experiencing their partners' psychological and physical control, exacerbating depressive symptoms, and placing the entire household at risk for experiencing food insecurity.…”

Section: Discussionmentioning

confidence: 99%

“…20,28 Therefore, among mothers who have experienced IPV, depressive symptoms may represent the severity of their negative psychological response to the violent experiences. In turn, depression may functionally impact their abilities to obtain food on a regular basis, likely due to factors such motivational and cognitive impairments, 28,35 decreased work productivity, 36 fewer supportive relationships, 37 and potentially including an inability to connect with individuals and institutions who may assist with food hardship.…”

Section: Intimate Partner Violence and Maternal Depressionmentioning

confidence: 99%

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Maternal Depression Mediates the Association Between Intimate Partner Violence and Food Insecurity

Hernandez

Marshall

Mineo

2014

Journal of Women's Health

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Background: Examination of maternal experiences of intimate partner violence (IPV) and depression as risk factors for food insecurity can provide a more nuanced understanding of the role that the family environment and women's health plays in the lives of families with young children that experience food insecurity. We investigated the longitudinal association between mothers' experiences of IPV and household food insecurity, and whether maternal depression mediated the relationship. Methods: IPV, depression, and food insecurity were assessed among 1,690 socioeconomically disadvantaged mothers of young children who participated in the Fragile Families and Child Wellbeing study. Longitudinal multivariate logistic regression models were used to examine the association between IPV measured 3 years after the child's birth and increase in food insecurity from child's third to fifth birthday, as well as the mediating role of maternal depression, controlling for a number of maternal and household characteristics. Results: Mothers who reside in food insecure households and those who experience IPV share similar characteristics of socioeconomic disadvantage and a greater propensity for depression compared to their counterparts. Mothers' experiences of IPV predicted an increased risk of household food insecurity two years later, and the relationship was mediated by maternal depression. Conclusions: Food insecure mothers may benefit from widespread assistance. Targeting issues central to women's health must become a priority in combating food insecurity. Having IPV and mental health screenings coincide with food assistance applications may help identify women who would benefit from resources designed to increase physical safety, psychological well-being, and food security.

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Section: Discussionmentioning

confidence: 99%

Section: Intimate Partner Violence and Maternal Depressionmentioning

confidence: 99%

Maternal Depression Mediates the Association Between Intimate Partner Violence and Food Insecurity

Hernandez

Marshall

Mineo

2014

Journal of Women's Health

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“…Despite the high incidence of depressive symptoms associated with the stroke framework, it seems that literature does not have enough studies with converging evidences concerning the frequency and the relationship between this psychiatric disease and stroke aspects, such as the lesion side and associated cognitive impairment (6) . More specifically, when comparing what has been found about cognitive impairment following a stroke in isolation (7) , as well as cognitive changes following depression cases (8) , little is known about the relationship between depression, unilateral right-hemisphere stroke and cognitive deficits derived by the association of these aspects.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, vascular lesions in this hemisphere may impair the patient's mental and emotional state, as well as negatively affecting motivation, comprehension and prosodic emotional, metaphoric and humor expression (10) . Some few existing studies (6,(11)(12)(13) propose to discuss the relationship between cognitive dysfunctions and post-stroke depression, but not followed by the association's investigation of the neurocognitive deficits of this comorbidity with the affected hemisphere. Among those studies, the research conducted by Alexopoulos (11) , for instance, emphasizes that lesions in the frontolimbic and frontoestriatic networks are associated withwith executive functions deficits; however, the contributions of each hemisphere are not considered in this process.…”

Section: Introductionmentioning

confidence: 99%

Depressive signs and cognitive performance in patients with a right hemisphere stroke

Oliveira

Pagliarin

Calvette

et al. 2015

CoDAS

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Purpose: This study investigated the influence of suggestive signs of depression (SSD) in right-hemisphere brain-damaged (RHD) patients following a stroke on their cognitive performance measured by a brief neuropsychological assessment battery. Methods: Forty-two adults with RHD after a single episode of stroke and 84 matched controls participated in this study. They were assessed by means of the Geriatric Depression Scale and by Brief Neuropsychological Assessment Battery NEUPSILIN. Results: Almost half of the patients showed SSD. The RHD group with SSD (RHD+) showed poorer performance in at least one task among all evaluated cognitive domains (concentrated attention, visual perception, working memory, episodic verbal memory and semantic memory, auditory and written language, constructional praxia and verbal fluency). Conclusion: The association of depression and RHD seems to enhance the occurrence and the severity of cognitive déficits. A brief neuropsychological assessment can be useful to identify cognitive impairment caused by this neuropsychiatric disorder.

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“…Over the past few years, growing evidence suggest that epigenetics, and notably histone acetylation, plays a role in neurodevelopmental, neurodegenerative, and neuropsychiatric diseases (47,54,57). Implication of histone acetylation was initially suggested by the observation that the use of HDACis, alone or in combination with antidepressants, ameliorates the behavior associated with severe depression in a rodent model (58).…”

Section: Histone Acetylation In Neuronal Dysfunctionsmentioning

confidence: 99%

Histone acetylation in neuronal (dys)function

Bonnaud¹,

Suberbielle²,

Malnou³

2016

Biomolecular Concepts

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Abstract:Cognitive functions require the expression of an appropriate pattern of genes in response to environmental stimuli. Over the last years, many studies have accumulated knowledge towards the understanding of molecular mechanisms that regulate neuronal gene expression. Epigenetic modifications have been shown to play an important role in numerous neuronal functions, from synaptic plasticity to learning and memory. In particular, histone acetylation is a central player in these processes. In this review, we present the molecular mechanisms of histone acetylation and summarize the data underlying the relevance of histone acetylation in cognitive functions in normal and pathological conditions. In the last part, we discuss the different mechanisms underlying the dysregulation of histone acetylation associated with neurological disorders, with a particular focus on environmental causes (stress, drugs, or infectious agents) that are linked to impaired histone acetylation.

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Cognitive impairment in major depression

Cited by 383 publications

References 43 publications

Maternal Depression Mediates the Association Between Intimate Partner Violence and Food Insecurity

Maternal Depression Mediates the Association Between Intimate Partner Violence and Food Insecurity

Depressive signs and cognitive performance in patients with a right hemisphere stroke

Histone acetylation in neuronal (dys)function

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