Cognitive impairment in patients with severe psoriasis

Marek-Józefowicz, Luiza; Jaracz, Marcin; Placek, Waldemar; Czajkowski, Rafał; Borkowska, Alina

doi:10.5114/ada.2017.67074

Cited by 19 publications

(25 citation statements)

References 33 publications

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“…Psoriasis cases scored significantly lower on cognitive tests than controls, especially with regard to working memory. While severity of psoriasis was not associated with cognitive function, longer duration of disease dramatically correlated with worse cognitive test results 31 …”

Section: Discussionmentioning

confidence: 76%

A preliminary study about neurofilament light chain and tau protein levels in psoriasis: Correlation with disease severity

Okan

Baki

Yorulmaz

et al. 2020

Clinical Laboratory Analysis

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Background Studies investigating cognitive dysfunction in psoriatic patients remain inconclusive. Objective To investigate the risk of cognitive decline in plaque‐type psoriasis patients. Methods Serum neurofilament light chain (NFL) and tau protein concentrations in 45 patients with plaque‐type psoriasis and forty‐five healthy controls were measured by enzyme‐linked immunosorbent assay (ELISA). Results Mean homeostasis model assessment (HOMA‐IR) values (6.82 vs 3.25) and serum levels of insulin (28.19 vs 15.71), NFL (5.74 vs 1.98), and tau (348.17 vs 207.30) in patients with psoriasis were found to be significantly higher than those of in healthy controls. There was a significant positive correlation between NFL and tau (r = .257, P = .015). There was significant correlation between NFL, tau and PASI (r = .310, P = .040) and (r = .383, P = .010), respectively. Significant correlations between NFL and insulin, TC, HDL‐C, TG, VLDL‐C, and BMI were found. NFL (9.38 vs 3.08) and tau (439.28 vs 281.58) concentrations and PASI values (23.94 vs 14.18) in patients with disease onset before 40 years were significantly higher than that of the patients with disease onset after 40 years. C‐reactive protein (CRP) was significantly correlated with BMI (r = .449, P < .001), LDL‐C (r = .240, P = .026), TG (r = .244, P = .024), and VLDL‐C (r = .241, P = .025) in patients with psoriasis. Conclusions Increased serum NFL and tau protein levels and the presence of positive correlations between NFL, tau protein and PASI score show cognitive decline risk may be higher in moderate‐to‐severe psoriasis.

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Section: Discussionmentioning

confidence: 76%

A preliminary study about neurofilament light chain and tau protein levels in psoriasis: Correlation with disease severity

Okan

Baki

Yorulmaz

et al. 2020

Clinical Laboratory Analysis

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“…Still, association of psoriasis with psychological, inflammatory, metabolic or other systemic diseases may pose these patients at risk for cognitive impairment [71]. Gisondi [73]. These studies showed differences in design, but psoriasis was an independent risk factor for cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?

Deveci

Kocacenk

Şahan

et al. 2019

Psychiatry and Clinical Psychopharmacology

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Objectives: Psoriasis is a chronic, inflammatory skin disease which has been linked to psychopathology. Oxidative stress and inflammation are associated with atherogenesis and neuronal stress thus, cognitive functions might be impaired in psoriasis patients. We aimed to compare psychiatric comorbidity, neurocognitive functions, oxidative stress and inflammatory cytokine levels in psoriasis patients with healthy controls, besides to evaluate the effect of oxidative stress and inflammation on comorbidity and cognitive functions in psoriasis patients. Methods: A total of 37 patients (11 male and 26 female) aged between 18 and 65 years with at least 5 years of education who applied to the Dermatology Outpatient Clinic of the study hospital between study period; diagnosed with psoriasis by physical examination and histopathological evaluation were included in the study. The control group was formed from healthy individuals working for the hospital. Sociodemographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Semantic Verbal Fluency Test (K-AS), Öktem Verbal Memory Processes Test, Auditory Consonant Trigram Test and Wisconsin Card Sorting Test were performed to all participants. In addition, blood samples of participants were analysed to assess total oxidant stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and proinflammatory cytokines TNF-α and IL-6 levels. Results: BDI and BAI scores, TOS, OSI, TNF-α and IL-6 levels of psoriasis patients were significantly higher than controls. Besides, the cognitive domains of learning, recall and verbal fluency in psoriasis patients were shown to be impaired. The increased levels of depression and anxiety in psoriasis did not significantly affect the serum TAS, TOS and OSI levels. Increased IL-6 and TNF-α levels were not significantly related to depression in patients with psoriasis. Conclusion: Psoriasis patients have higher risk factors than healthy controls for cognitive impairment, independent of depression, inflammation and oxidative stress levels.

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“…It has been shown that PS patients may suffer from cognitive impairment [37][38][39]. For instance, a recent study on patients with severe PS revealed that they scored lower in neuropsychological tests that assessed working memory and executive function (e.g., the trail-making test, the Stroop color-word interference test, and the Beck Depression Inventory [BDI]) than a healthy control group and independently of depressive symptom severity [37].…”

Section: Evidence For An Association Of Skin Disease With Cognitive Imentioning

confidence: 99%

“…For instance, a recent study on patients with severe PS revealed that they scored lower in neuropsychological tests that assessed working memory and executive function (e.g., the trail-making test, the Stroop color-word interference test, and the Beck Depression Inventory [BDI]) than a healthy control group and independently of depressive symptom severity [37]. In the same study, a longer duration of PS significantly correlated with worse outcomes on measures of working memory and executive function.…”

Section: Evidence For An Association Of Skin Disease With Cognitive Imentioning

confidence: 99%

“…In the same study, a longer duration of PS significantly correlated with worse outcomes on measures of working memory and executive function. This may be suggestive of the adverse effects of chronic inflammation on the prefrontal cortex which supports important cognitive processes such as decision-making and attention [37]. In a study on AD patients, cortisol, ACTH, and catecholamine concentrations were assessed before and after a stressful task (the Trier social stress test) to investigate the sensitivity of the HPA axis.…”

Section: Evidence For An Association Of Skin Disease With Cognitive Imentioning

confidence: 99%

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Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease

Farzanfar

Dowlati

French

et al. 2018

Skin Pharmacol Physiol

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The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. The published literature over the past 5 years was reviewed for evidence of a relationship between depression and inflammatory processes in the context of skin pathology. The findings, particularly the evidence from interventional clinical trials of targeted anti-cytokine therapies, suggest that pro-inflammatory cytokines associated with several skin diseases may be causally linked with the coexistent depressive symptomology.

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Cognitive impairment in patients with severe psoriasis

Cited by 19 publications

References 33 publications

A preliminary study about neurofilament light chain and tau protein levels in psoriasis: Correlation with disease severity

A preliminary study about neurofilament light chain and tau protein levels in psoriasis: Correlation with disease severity

Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?

Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease

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