Cognitive Impairment in Patients with Ankylosing Spondylitis

Vitturi, Bruno Kusznir; Suriano, Enrico Stefano; Sousa, Ana Beatriz Pereira De; Torigoe, Dawton Yukito

doi:10.1017/cjn.2020.14

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…The specific areas of cognitive impairment in RA shown in the present study (memory, verbal fluency, executive function and emotional recognition) have been reported in RA in other settings, summarized in a recent systematic review [ 7 ]. Furthermore, emerging evidence of a similar pattern of cognitive impairment in other rheumatic diseases has been reported [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 66%

Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

Gwinnutt

Toyoda

Jeffs

et al. 2021

Rheumatology Advances in Practice

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Objectives To compare the cognitive ability of people with rheumatoid arthritis (RA) with healthy controls (HCs). Methods People with RA were recruited from the Norfolk Arthritis Register (NOAR), a population-based cohort study of people with inflammatory arthritis. Data on aged-matched HCs (people with no cognitive impairment) came from the comparison arm of The Dementia Research and Care Clinic Study (TRACC). People with RA and HCs performed a range of cognitive ability tasks assessing: attention, memory, verbal fluency, language, visuospatial skills, emotional recognition, executive function and theory of mind. A score of < 88 on the Addenbrooke’s Cognitive Examination-III (ACE-III) was considered cognitive impairment. Scores were compared using linear regression adjusting for age, gender, smoking status, education, body mass index, anxiety and depression. Results Thirty-eight people with RA (mean [standard deviation (SD)] age: 69.1 [8.0]; 25 [65.8%] women) were matched with 28 HCs (mean [SD] age: 68.2 [6.4]; 15 [53.6%] women). Twenty-three (60.5%) people with RA were considered to have mild cognitive impairment (mean [SD] ACE-III: RA = 85.2 [7.4], HC = 96.0 [2.5]). People with RA had impairments in memory, verbal fluency, visuospatial functioning, executive function, and emotional recognition in faces compared with HCs, after adjustment for confounders. Conclusions People with RA had cognitive impairments in a range of domains. People with RA may benefit from cognitive impairment screening to allow for early administration of appropriate interventions.

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Section: Discussionmentioning

confidence: 66%

Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

Gwinnutt

Toyoda

Jeffs

et al. 2021

Rheumatology Advances in Practice

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“…The performance of patients with AS was lower than that of healthy controls in verbal fluency and CDT of the BCSB and in the Montreal Cognitive Assessment (MoCA). 66 …”

Section: Resultsmentioning

confidence: 99%

“…The performance of patients with AS was lower than that of healthy controls in verbal fluency and CDT of the BCSB and in the Montreal Cognitive Assessment (MoCA). 66 A recent study investigated the accuracy of the BCSB in the differential diagnosis between AD, non-AD cognitive impairment (both defined by cerebrospinal fluid AD biomarkers) and healthy cognition. The study included 117 individuals, being 45 with MCI or mild dementia within the AD continuum defined by the AT(N) classification (i.e., A+), 27 non-AD (A-) MCI or mild dementia patients, and 45 cognitively healthy individuals.…”

Section: Influence Of Education Construct Validity and Normative Studiesmentioning

confidence: 99%

The Figure Memory Test: diagnosis of memory impairment in populations with heterogeneous educational background

Nitrini

Bucki

Yassuda

et al. 2021

Dement. neuropsychol.

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ABSTRACT. Diagnosis of cognitive impairment is usually difficult in low-educated individuals. The Brief Cognitive Screening Battery (BCSB) was designed as a screening tool for the evaluation of cognitive impairment in low-educated individuals, but it may also be used for evaluating individuals with high educational level. Objectives: To perform a narrative review analyzing the origin of the BCSB, to report all studies that have used the Figure Memory Test (FMT) of the BCSB, and to demonstrate that it is a useful battery for regions where populations have heterogeneous educational background. Methods: We performed a search in PubMed, SciELO, and LILACS using the terms “Brief Cognitive Screening Battery” and “Brief Cognitive Battery”. Results: We obtained 49 papers from PubMed, 32 from SciELO, and 28 from LILACS. After the exclusion of duplicate papers, 54 publications were obtained; five more studies were included from previous knowledge of the authors. Twenty-four papers were related to the impact of education on performance, diagnostic accuracy, cutoff scores and normative studies. The delayed recall of the FMT showed the best accuracy for the diagnosis of dementia with a cutoff score of ≤5 in different education levels. In 35 papers, the FMT of the BCSB was used in clinical studies with different settings, from outpatient memory clinics to epidemiological studies and evaluation of Amazon river basin dwelling individuals, and it was always considered to be easy to apply. Conclusions: The FMT of the BCSB is an easy and short tool for the diagnosis of dementia in populations with heterogeneous educational background.

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“…Negative symptoms have been associated with inflammatory mechanisms [48] and include avolition and affective flattening, with the involvement of reward mechanisms [9]. Negative symptoms have been associated with a lower level of social functioning [49] and poorer cognitive performance [50], both of which are widely cited as part of the clinical picture during the progression of RA [51,52] and SpA [53,54]. Therefore, the presence of negative subclinical symptoms gains in importance owing to the effect on both social and cognitive functioning, the involvement of which also affects quality of life [38] and disability [55].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis

Prados-Ojeda

Luque-Luque

Gordillo-Urbano

et al. 2021

JCM

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Inflammatory and autoimmune processes have been associated with the onset of depressive and psychotic symptoms. Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are rheumatic diseases with an inflammatory etiology. A high prevalence of depressive and anxiety-related comorbidity has been reported for both diseases, with no evidence of a greater prevalence of psychosis. The objective of the present study was to evaluate for the first time subclinical psychotic symptoms in patients with RA and SpA. This is a cross-sectional, single-center study including RA and SpA patients, as well as healthy controls. Abnormal psychotic experiences (positive, negative, and depressive symptoms) were evaluated using the Community Assessment of Psychic Experiences (CAPE-42). Functional capacity was evaluated using the Short-Form Health Survey SF-12. We compared the CAPE and SF-12 scores between the three groups. We recruited 385 individuals: 218 with RA, 100 with SpA, and 67 healthy controls. According to the CAPE scale, the frequency of subclinical psychotic symptoms was greater in patients than in healthy controls (RA, 1.90 vs. 1.63, p < 0.001; SpA, 1.88 vs. 1.63, p = 0.001). Distress was also greater in patients than in controls owing to the presence of symptoms. No differences were observed between the three groups for the mental dimension scores in the SF-12 Health Survey (43.75 in RA, 45.54 in SpA, and 43.19 in healthy controls). Our findings point to a greater prevalence of subclinical psychotic symptoms in patients with RA and patients with SpA than in the general population. The results suggest an association between inflammation and depression/subclinical psychotic symptoms.

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Cognitive Impairment in Patients with Ankylosing Spondylitis

Cited by 16 publications

References 39 publications

Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

The Figure Memory Test: diagnosis of memory impairment in populations with heterogeneous educational background

Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis

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