Cognitive impairment in young adults with infratentorial infarcts

Abstract

Cerebellar damage impairs central aspects of attention and visuospatial skills. In contrast, intelligence and episodic memory remain unchanged. When the lesion involves large portions of the cerebellar hemispheres, changes concerning broad areas of intelligence may occur. The prognosis is favorable for neurologic dysfunction, but cognitive deficits may prevent return to work.

Hemispatial neglect in cerebellar stroke

“…A subsequent study, however, did not replicate these results, but rather found an inverse correlation between the lesion volume and the cognitive impairments [27]. Our results showed that the mean lesion size of the patients with neglect was much larger than those without neglect supporting Malm et al's result [26]. Although the reason for this discrepancy is not entirely clear, our patients' lesions appeared to be larger than those of Kalashnikova et al's patients [27] and even larger than those of the cognitively normal group in their study.…”

“…One study found a clear correlation between cognitive impairments and the CT-based estimates of infarct size [26]. A subsequent study, however, did not replicate these results, but rather found an inverse correlation between the lesion volume and the cognitive impairments [27].…”

11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

“…11␤-HSD activity was detected in both human cerebellum and hippocampus, with higher activity in cerebellar homogenates, suggesting that this may also be the case in humans. Although the function of 11␤-HSD1, and indeed of glucocorticoids, in the cerebellum is unclear, this structure is known to be involved in cognition in humans (55,56). The hippocampus and frontal cortex are more clearly related to cognition and here glucocorticoids play well defined roles modulating learning and memory (57).…”

Working Memory: Maintenance, Updating, and the Realization of Intentions

“…Prefrontal and parietal cortex regions form circuits with cerebellar regions, and both imaging studies (Stoodley and Schmahmann 2009;Marvel and Desmond 2010) and studies of patients with brain damage (Malm et al 1998) implicate the cerebellum in working-memory manipulation. Moreover, a frontostriatal -cerebellar circuit is thought to have a general control function in resource-demanding long-term and workingmemory tasks (Marklund et al 2007a).…”