Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China

Cui, Guo-Hong; Yao, Yu-Hui; Xu, Rui-Fang; Tang, Huidong; Jiang, Guo-Xin; Wang, Ying; Wang, G.; Chen, S.-D.; Cheng, Qi

doi:10.1111/j.1600-0404.2010.01484.x

Cited by 145 publications

(110 citation statements)

References 30 publications

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“…The diagnostic cutoff points for cognitive impairment are 17 for illiterates, 20 for primary school graduates, and 24 for high school graduates or above. These cutoffs have a sensitivity from 80% to 90%, and a specificity form 70% to 80% (Cui et al, 2011;Katzman et al, 1988).…”

Section: Evaluation Of Covariatesmentioning

confidence: 99%

Does residing in urban or rural areas affect the incidence of polypharmacy among older adults in western China?

Yang

Qin

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Evaluation Of Covariatesmentioning

confidence: 99%

Does residing in urban or rural areas affect the incidence of polypharmacy among older adults in western China?

Yang

Qin

et al. 2015

Archives of Gerontology and Geriatrics

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“…Cognitive function was measured using the Chinese version of the MMSE (Cui et al, 2011;Katzman et al, 1988), which is widely used for assessing cognitive mental status. MMSE scores ranged from 0 to 30, with higher scores indicating better cognition.…”

Section: Assessment Of Cognitive Functionmentioning

confidence: 99%

Associations between social networks, social contacts, and cognitive function among Chinese nonagenarians/centenarians

Wang

Dong

2015

Archives of Gerontology and Geriatrics

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“…Aging and Disease • Volume 6, Number 4, August 2015 239 [16]. According to the previous study, the AVLT immediate recall (a full score of 36) and long delayed free recall (20 minutes after with a full score of 12) were measured to assess the memory of subjects [17].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Clinical Characteristics for the Relationship between Type-2 Diabetes Mellitus and Cognitive Impairment: A Cross-Sectional Study

Zhou

Fang

Liu³

et al. 2015

Aging and disease

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ABSTRACT:We explored the potential differences in cognitive status, lipid and glucose metabolism, ApoEε4 alleles and imaging between diabetic and non-diabetic subjects. 83 subjects with normal cognitive function and 114 mild cognitive impaired patients were divided into four groups by history of diabetes. General demographics was collected from all participants followed by MRI scan, biochemical examinations and a series of neuropsychological tests. Student's t test, multiple regressions and one-way ANOVA were applied to investigate the differences between groups. Comparing diabetic patients with non-diabetic subjects in the mild cognitive impaired group, we found several decreased items in recall of three words in MMSE (p=0.020), AVLT and SCWT (p＜0.050). The multiple linear regression revealed that two-hour glucose level (B= -0.255，p＜0.001) and fasting C-peptide (B= -0.466， p=0.001) had negative effects on the score of MMSE. In addition, diabetic patients treated with insulin and other diabetes medication performed better in part of the AVLT (p＜0.050) compared to patients with insulin treatment or oral antidiabetic medication only. Patients with metformin medication had a better memory outcome compared to patients with sulphonylurea medication in the AVLT long delay free recall (p =0.010). These findings show that patients of mild cognitive impairment with diabetes mellitus have a worse outcome in attention, information processing speed and memory compared to non-diabetic patients. Higher two-hour glucose level and C-peptide level may be risk factors for severe cognitive impairment in type-2 diabetes mellitus patients. The results of this study also suggest that medication may have effects on cognitive function.Key words: Type-2 diabetes mellitus, mild cognitive impairment, C-peptide, blood glucoseThe incidence of type-2 diabetes mellitus (T2DM) in China has dramatically increased in the last decade. Besides the well-known connection between T2DM and peripheral nervous system disease, the diabetes-induced lesions in the central nervous system (CNS), such as cerebrovascular disease and cognitive dysfunction, are receiving increased attention. Several epidemiological studies have found that T2DM is an independent risk factor for both Alzheimer's disease (AD) and vascular dementia (VaD) [1,2]. In addition, further research has shown that T2DM may also exercise influence on the prevalence of mild cognitive impairment (MCI), which is considered a pre-clinical stage of dementia. In Luchsinger and colleagues' study [3], the results indicated that diabetes mellitus is related to a relatively higher risk for all causes of MCI (about 1.5 fold). In another recent metaanalysis report, diabetes was shown to have higher risk for any dementia and MCI (1.46 for AD, 2.48 for VaD and 1.21 for MCI) [4].The present studies have confirmed that T2DM is a robust risk factor for cognitive dysfunction. However, the precise mechanisms remain to be elucidated [5]. A wide range of metabolic and vascular disturbances have been proposed to e...

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Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China

Abstract: This study demonstrates that screening of CI using the AEL cutoff scores is feasible in a low-education population. Determining whether the 23/24 cutoff point is suitable for the Chinese people requires future prospective studies in a large Chinese population.

Cited by 145 publications

References 30 publications

Does residing in urban or rural areas affect the incidence of polypharmacy among older adults in western China?

Does residing in urban or rural areas affect the incidence of polypharmacy among older adults in western China?

Associations between social networks, social contacts, and cognitive function among Chinese nonagenarians/centenarians

Clinical Characteristics for the Relationship between Type-2 Diabetes Mellitus and Cognitive Impairment: A Cross-Sectional Study

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