Cognitive impairments in advanced PD without dementia

Green, J.; McDonald, William M.; Vitek, Jerrold L.; Evatt, Marian L.; Freeman, Alan; Haber, Michael; Bakay, Roy A.E.; Triche, Shirley; Sirockman, B.; DeLong, Mahlon R.

doi:10.1212/01.wnl.0000031426.21683.e2

Cited by 182 publications

(154 citation statements)

References 28 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…These cognitive measures are known to be sensitive to PD [CVLT (Massman et al, 1990;Green et al, 2002); Trails B (Muslimovic et al, 2005); Hooper (Levin et al, 1991); SDMT (Muslimovic et al, 2005)]. Although PDCP scores correlated with test measures in which the subjects were deficient, pattern expression also correlated with those tasks that the subjects performed well.…”

Section: Neuropsychological Correlates Of Pdcp Activitymentioning

confidence: 99%

“…The dementia of PD typically includes difficulties in executive and visuospatial functions, as well as memory and language deficits (Bosboom et al, 2004). By contrast, more circumscribed executive deficits, as well as secondary disturbances of memory and visuospatial function, have been described in nondemented PD patients (Green et al, 2002;cf., Zgaljardic et al, 2003;Bosboom et al, 2004 for reviews). Such subtle behavioral/cognitive deficits may have a major impact on the quality of life of PD patients (Schrag et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…The depletion of striatal dopamine has also been suggested as a cause for the cognitive deficits of PD (Green et al, 2002). The direct dopaminergic connections between the ventral tegmental area and the prefrontal cortex may also influence changes in cognition in this disease (e.g., Mattay et al, 2002;cf., Cools, 2006 for review).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic brain networks associated with cognitive function in Parkinson's disease

et al. 2007

View full text Add to dashboard Cite

The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non-demented PD patients using FDG PET and a voxel-based network modeling approach. We detected a significant covariance pattern that correlated (p< 0.01) with performance on tests of memory and executive functioning. This PD-related cognitive pattern (PDCP) was characterized by metabolic reductions in frontal and parietal association areas and relative increases in the cerebellar vermis and dentate nuclei. To validate this pattern, we analyzed data from 32 subsequent PD patients of similar age, disease duration and severity. Prospective measurements of PDCP activity predicted memory performance (p<0.005), visuospatial function (p<0.01), and perceptual motor speed (p<0.005) in this validation sample. PDCP scores additionally exhibited an excellent degree of test-retest reliability (intraclass correlation coefficient, ICC=0.89) in patients undergoing repeat FDG PET at an 8-week interval. Unlike the PD-related motor pattern, PDCP expression was not significantly altered by antiparkinsonian treatment with either intravenous levodopa or deep brain stimulation (DBS). These findings substantiate the PDCP as a reproducible imaging marker of cognitive function in PD. Because PDCP expression is not altered by routine antiparkinsonian treatment, this measure of network activity may prove useful in clinical trials targeting the progression of non-motor manifestations of this disorder.

show abstract

Section: Neuropsychological Correlates Of Pdcp Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic brain networks associated with cognitive function in Parkinson's disease

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Moreover, already in the early stages of PD some 20% of patients have mild cognitive impairment [1]. Because of the underlying neurodegenerative nature of PD, cognitive impairments are overall related to increased motor severity [2]. For example, the motor subtype with predominantly posture and gait disorders is a strong predictor of severe cognitive decline [3].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the motor subtype with predominantly posture and gait disorders is a strong predictor of severe cognitive decline [3]. However, associations between more specific aspects of cognitive function and motor impairments are less clear [2].…”

Section: Introductionmentioning

confidence: 99%

Involvement of specific executive functions in mobility in Parkinson's disease

Smulders

Nimwegen

Munneke

et al. 2013

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

a b s t r a c tPostural instability and gait disorders (PIGD) in Parkinson's disease (PD) seem to be associated with executive dysfunction. We investigated which specific executive functions are associated with functional mobility in mildly affected PD patients. Functional mobility (Timed Up&Go Test, TUG), PIGD score, (spatial) working memory, set shifting, response inhibition and response generation were assessed in a large cohort of 232 non-demented PD patients. Both performance on the TUG and PIGD score were weakly associated with working memory and response generation (semantic and phonemic fluency). TUG also correlated with semantic fluency when corrected for disease severity and age. These results indicate that response generation and working memory are associated with (and possibly also causally related to) gait and balance deficits. In order to fully interpret gait and postural stability of PD patients in everyday situations, the role of impairments in working memory and response generation should be taken into account.

show abstract

Deep Brain Stimulation for Patients With Advanced Parkinson Disease

Genever¹

2009

JAMA

View full text Add to dashboard Cite

Cognitive impairments in advanced PD without dementia

Abstract: Even in the absence of dementia or depression, patients with advanced PD are likely to show clinically significant impairments on neuropsychological measures sensitive to changes in dorsolateral prefrontal regions participating in cognitive basal ganglia-thalamocortical circuits.

Cited by 182 publications

References 28 publications

Metabolic brain networks associated with cognitive function in Parkinson's disease

Metabolic brain networks associated with cognitive function in Parkinson's disease

Involvement of specific executive functions in mobility in Parkinson's disease

Deep Brain Stimulation for Patients With Advanced Parkinson Disease

Contact Info

Product

Resources

About