Cognitive improvement in meningioma patients after surgery: clinical relevance of computerized testing

Meskal, Ikram; Gehring, Karin; Linden, S.D. van der; Rutten, Geert‐Jan; Sitskoorn, Margriet M.

doi:10.1007/s11060-014-1679-8

Cited by 70 publications

(73 citation statements)

References 18 publications

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“…All patients provided written informed consent. There is considerable overlap between the patient sample of this study and four previously published studies …”

Section: Methodsmentioning

confidence: 95%

Subjective cognitive functioning in patients with a meningioma: Its course and association with objective cognitive functioning and psychological symptoms

et al. 2019

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Objective Although meningioma patients show deficits in objective cognitive functioning (OCF) measured with neuropsychological tests, subjective cognitive functioning (SCF) has received little attention. We investigate SCF from pre‐ to postsurgery and its associations with OCF, psychological, sociodemographic, and clinical characteristics. Methods SCF was measured using the Cognitive Failures Questionnaire (CFQ) 1 day before (T0) and 3 (T3) and 12 months (T12) after surgery. Patients' scores were compared with normative data and changes over time were assessed. The neuropsychological battery CNS Vital Signs and the Hospital Anxiety and Depression Scale were administered. Correlations of SCF with OCF, psychological, sociodemographic, and clinical characteristics were explored. Results Patients reported significantly better SCF as compared with controls at T0 (N = 54) and T3 (N = 242), but not at T12 (N = 50). A significant decrease in group level SCF was observed from T0 to T12 (n = 24, P < .001). SCF was associated with anxiety at all time points (rs = −0.543 to −0.352) and with depression at T3 and T12 (r = −0.338 and −0.574), but not with OCF, sociodemographic, or clinical characteristics (rs = −0.202 to 0.288). Conclusions Meningioma patients experienced better SCF as compared with controls before and 3 months after surgery, which might be the result of phenomena related to disease and recovery. As the findings suggest that cognitive symptoms might increase later on, future studies should further investigate the course of SCF in meningioma patients. In clinical practice, measurements of SCF should be combined with those of OCF and psychological distress in order to determine whether and which interventions are needed.

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“…All patients provided written informed consent. There is considerable overlap between the patient sample of this study and four previously published studies …”

Section: Methodsmentioning

confidence: 95%

Subjective cognitive functioning in patients with a meningioma: Its course and association with objective cognitive functioning and psychological symptoms

et al. 2019

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“…Other studies have reported significant cognitive impairment in meningioma patients either pre- or post- surgery [9, 10], although the average tumor size in both of these studies was much greater than the average size of tumor in our study. Those looking at patients both before and after surgery show mixed findings based on factors such as type of intervention, meningioma size, and patient characteristics [7, 8, 19, 20]. Previous authors have suggested the cognitive impairment could be due to mass effect, edema, and even extra-tumor factors such as seizures and anti-seizure medications.…”

Section: Discussionmentioning

confidence: 99%

Neurocognition in individuals with incidentally-identified meningioma

et al. 2017

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Meningiomas are primary intracranial tumors that are often asymptomatic. To our knowledge, no study has attempted to describe neurocognitive function in patients with incidentally-discovered meningioma. We utilized the Mayo Clinic Study of Aging (MCSA), which is a population-based sample of Olmsted County, Minnesota residents that includes neuropsychological testing and brain MRI approximately every 15 months. Using a text search of radiologists’ notes of 2,402 MCSA individuals (mean age 77 years, scanned between 2004 and 2014) we identified 48 eligible subjects (2%) who had at least one meningioma. Most meningiomas were small (90% < 3cm). We matched each of the 48 subjects to five non-demented MCSA controls (n = 240) on age, sex, and education. Cognitive domains assessed included memory, attention-executive function, language, and visuospatial. More women (67%) had a meningioma than men (33%). Groups did not differ on prevalence of Mild Cognitive Impairment (Meningioma = 19%, Controls = 13%). Across cognitive domains, we observed similar performance for the two groups (p’s ≥ 0.21). Subtle differences emerged in memory and language domains (p = 0.05 and p = 0.11) when we divided the Meningioma group by tumor location, wherein the small group with an infratentorial tumor performed more poorly than controls globally as well as on select memory and language measures. Our findings suggest that small meningiomas are generally cognitively benign, but that may change as the tumor evolves, and might be impacted by other factors such as meningioma location.

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“…Study participants with a primary diagnosis of central nervous system cancer were the most likely to report PCD (81 %). This percentage is likely high due to direct tumor impact in survivors of primary brain tumors [31, 32], and may also be due to treatment-related factors such as the known side effects of bevacizumab and anti-epileptic drugs that are normally prescribed for CNS cancer patients [33, 34]. However, PCD was widely reported among survivors of all cancer types with about half of the study participants with breast, lymphoma, colorectal, and head and neck cancers reporting PCD (44.2–57.6 %, see Fig.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of perceived cognitive dysfunction in survivors of a wide range of cancers: results from the 2010 LIVESTRONG survey

et al. 2015

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Purpose With cancer survivors now numbering over 13 million in the United States, and expected to continue to increase, it is important to consider the needs of this growing population. In the literature, one of the most common complaints by cancer survivors is perceived cognitive dysfunction. Since the preponderance of the research has focused on breast cancer survivors, the purpose of the present study was to explore the prevalence and correlates of perceived cognitive dysfunction in a large sample of cancer survivors with representation across a wide range of different types of cancer. Methods A sample of 3108 post-treatment cancer survivors completed the 2010 LIVESTRONG survey as part of a larger study of cancer survivorship. Respondents completed standardized questions regarding current and past perceived cognitive dysfunction, as well as depressive symptoms, and demographic and medical variables. Results Current perceived cognitive dysfunction was reported by nearly half of respondents (45.7 %), across a wide range of cancer types, with the highest prevalence among survivors of central nervous system cancers. Receiving chemotherapy and current report of depressive symptoms were both strongly associated with current perceived cognitive dysfunction. Conclusion These findings contribute to a growing appreciation of the high prevalence of perceived cognitive dysfunction in survivors of a wide range of cancer types and the potential interactive effect of concurrent symptoms of depression. These findings highlight a need to develop more effective means of preventing or reducing cognitive dysfunction in cancer survivors. Implications for Cancer Survivors Perceived cognitive dysfunction was reported in a wide range of cancer survivors. The potential interactive effect of symptoms of depression suggests the need to develop interventions targeting both cognitive dysfunction and depression to achieve improvements in cognitive functioning.

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Cognitive improvement in meningioma patients after surgery: clinical relevance of computerized testing

Cited by 70 publications

References 18 publications

Subjective cognitive functioning in patients with a meningioma: Its course and association with objective cognitive functioning and psychological symptoms

Subjective cognitive functioning in patients with a meningioma: Its course and association with objective cognitive functioning and psychological symptoms

Neurocognition in individuals with incidentally-identified meningioma

Prevalence of perceived cognitive dysfunction in survivors of a wide range of cancers: results from the 2010 LIVESTRONG survey

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