Cognitive improvements in a rat model with polyunsaturated fatty acids EPA and DHA through α7-nicotinic acetylcholine receptors

Inhibitory Activity of 4-Benzylidene Oxazolones Derivatives of Cinnamic Acid on Human Acetylcholinesterase and Cognitive Improvements in a Mouse Model

“…We used validated mouse models applied by Arunrungvichian et al [30] to evaluate the agonist activity-substituted 1,2,3-triazoles for nicotinic acetylcholine receptors. Previous to the current work, we applied the testing methods to determine the effective doses of omega-3 fatty acids, EPA, and DHA, for cognition improvement in rats [31].…”

“…Previous to the current work, we applied the testing methods to determine the effective doses of omega-3 fatty acids, EPA, and DHA, for cognition improvement in rats [31].…”

“…Spatial working memory was assessed using the modified Y-maze test [31,32]. In this test, rodents tend to explore new arms of the maze instead of revisiting previously visited ones [33].…”

“…We meticulously recorded the time the mice spent exploring each object, defined as when their noses approached within 3 cm or when they made contact with the objects. The DI was calculated as (TN -TF)/(TN + TF), with TN representing the exploration time of the new object and TF indicating the exploration time of the familiar object [31].…”

Potential of food-derived bioactive peptides in alleviation and prevention of Alzheimer's disease

“…Currently, substances that have been studied to ameliorate memory loss include herbal extracts, fruit extracts, lecithin, polyunsaturated fatty acids, and peptides. [14][15][16][17][18] Among these, several studies have clarified that food-derived bioactive peptides have neuroprotective and cognitive-improvement functions. The most common sources of bioactive peptides include eggs, meat, fish, soybeans, wheat, milk, and their derivatives.…”