Cognitive inhibition and working memory in unipolar depression

Abstract

Depressed patients showed inability to inhibit neutral information access to working memory, restrain and delete irrelevant information. This impairment in cognitive inhibition could underlie cognitive slowness and attentional deficits in depression.

Computerized Victoria Stroop Test in Adult Unipolar Depressed Patients and Healthy Subjects: Influence of Age and Gender

“…As in previous studies, there were no significant differences in execution time (cognitive slowness) between depressive subjects and healthy controls (Gohier et al, 2009), despite the first having exhibited a slower performance.…”

“…Alterations in execution time (Gohier et al, 2009), as well as in interference (Harvey et al, 2004;Stordal et al, 2004), are common in depression. Concerning unipolar depressed patients, rostral anterior cingulate gyrus (rACG) and left dorsolateral prefrontal cortex (DLPFC) is involved in interference (Wagner et al, 2006).…”

“…This study utilized a computerized version of the Victoria Stroop Test (VST) that took less time to be applied and could be found in public domain. According to literature (Gohier et al, 2009;Harvey et al, 2004;Stordal et al, 2004), we hypothesized that depressed patients would be outperformed by healthy controls and that younger subjects would perform faster in both groups, being execution time influenced by age. Performance of depressive patients tended to improve during the course of antidepressant treatment (Wagner, Doering, Helmreich, Lieb, & Tadić, 2012), however, in the current study, it was not possible to assess drug-free depressed subjects.…”

Executive functions in major depressive disorder

“…Poor performance on the DSST and DVT i.e., 30% and 32% respectively, and poorer performance on the Stroop test in the present sample is in line with existing literature (14,15,16,17). But some other studies have reported no difference in performance of executive functions between depressed and control groups (18,19).…”

The Role of Blue Native/ SDS PAGE in Depression Research

“…Over the past decade, evidence has accumulated to suggest that patients with depression were significantly impaired on tasks of attention, executive function, memory and psychomotor speed. These findings suggest deficits in cognitive function, attention, visual and verbal memory and learning, as vulnerability marker for major depressive disorder (Channon & Green, 1999;Gohier et al, 2009;Weingartner et al, 1981).…”