Cognitive judgment bias in the psychostimulant-induced model of mania in rats

Ryguła, Rafał; Szczech, Ewa; Kregiel, J.; Golebiowska, Joanna; Kubik, Jakub; Popik, Piotr

doi:10.1007/s00213-014-3707-y

Cited by 21 publications

(16 citation statements)

References 48 publications

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“…The experimental training and testing procedures for the ambiguous-cue interpretation (ACI) paradigm used in this study were modified from procedures previously described by Enkel et al ( 2010 ) and have been described in detail elsewhere (Rygula et al, 2012 , 2013 , 2014a , b , c , 2015 ; Papciak et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of optimism on motivation in rats

Ryguła

Golebiowska²,

Kregiel³

et al. 2015

Front. Behav. Neurosci.

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In humans, optimism is a cognitive construct related to motivation; optimists exert effort, whereas pessimists disengage from effort. In this study, using a recently developed ambiguous-cue interpretation (ACI) paradigm we took the unique opportunity to investigate whether “optimism” as a trait is correlated with motivation in rodents. In a series of ACI tests (cognitive bias screening, CBS), we identified rats displaying “pessimistic” and “optimistic” traits. Subsequently, we investigated the trait differences in the motivation of these rats to gain reward and to avoid punishment using a progressive ratio (PR) schedule of reinforcement paradigm. Although “optimistic” and “pessimistic” animals did not differ in their motivation to avoid punishment, the “optimistic” rats were significantly more motivated to gain reward than their “pessimistic” conspecifics. For the first time, we showed an association between cognitive judgment bias and motivation in an animal model. Because both investigated processes are closely related to mental health and wellbeing, our results may be valuable for preclinical modeling of many psychiatric disorders.

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Section: Methodsmentioning

confidence: 99%

Effects of optimism on motivation in rats

Ryguła

Golebiowska²,

Kregiel³

et al. 2015

Front. Behav. Neurosci.

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“…The main aim of judgment bias studies in biomedical research has been to investigate effects of experimental manipulations expected to affect mood in animal models of mood disorders such as depression and/or anxiety. Most of these studies have tested the effects of anxiolytics and/or anti-depressants on judgment bias performance (e.g., Doyle et al, 2011a ; Destrez et al, 2012 ; Hymel and Sufka, 2012 ; Anderson et al, 2013 ; Rygula et al, 2014a , b , 2015c ).…”

Section: Usability For Biomedical Researchmentioning

confidence: 99%

Making Decisions under Ambiguity: Judgment Bias Tasks for Assessing Emotional State in Animals

Roelofs

Boleij

Nordquist

et al. 2016

Front. Behav. Neurosci.

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244

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Judgment bias tasks (JBTs) are considered as a family of promising tools in the assessment of emotional states of animals. JBTs provide a cognitive measure of optimism and/or pessimism by recording behavioral responses to ambiguous stimuli. For instance, a negative emotional state is expected to produce a negative or pessimistic judgment of an ambiguous stimulus, whereas a positive emotional state produces a positive or optimistic judgment of the same ambiguous stimulus. Measuring an animal’s emotional state or mood is relevant in both animal welfare research and biomedical research. This is reflected in the increasing use of JBTs in both research areas. We discuss the different implementations of JBTs with animals, with a focus on their potential as an accurate measure of emotional state. JBTs have been successfully applied to a very broad range of species, using many different types of testing equipment and experimental protocols. However, further validation of this test is deemed necessary. For example, the often extensive training period required for successful judgment bias testing remains a possible factor confounding results. Also, the issue of ambiguous stimuli losing their ambiguity with repeated testing requires additional attention. Possible improvements are suggested to further develop the JBTs in both animal welfare and biomedical research.

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“…Repeated administration of the same dose of cocaine induced hyperactivity and elevated stereotypy responses in rats (Kilbey and Ellinwood 1977; Post 1990). A drug-high state after the administration of psychostimulants was furthermore associated with increased aggression (Borison et al 1978; Davies et al 1974), a declined cognitive performance (Fries et al 2015; Rygula et al 2015) and deficits in prepulse inhibition (PPI) (Zheng et al 2013). Several different psychostimulants were administrated to induce mania-like behavior.…”

Section: Introductionmentioning

confidence: 99%

“…Another limitation of the psychostimulant induced animal models for BD mania is that only a few simple aspects of human mania, like hyperactivity, are mimicked and even the amphetamine-induced hyperactivity is not specific for BD (Logan and McClung 2016; Rygula et al 2015). …”

Section: Introductionmentioning

confidence: 99%

Animal models for bipolar disorder: from bedside to the cage

Beyer

Freund

2017

Int J Bipolar Disord

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Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed. Animal models can be useful tools in understanding brain mechanisms associated with certain behavior. The following review discusses several pathological aspects of humans suffering from bipolar disorder and compares these findings with insights obtained from several animal models mimicking diverse facets of its symptomatology. Various sections of the review concentrate on specific topics that are relevant in human patients, namely circadian rhythms, neurotransmitters, focusing on the dopaminergic system, stressful environment, and the immune system. We then explain how these areas have been manipulated to create animal models for the disorder. Even though several approaches have been conducted, there is still a lack of adequate animal models for bipolar disorder. Specifically, most animal models mimic only mania or depression and only a few include the cyclical nature of the human condition. Future studies could therefore focus on modeling both episodes in the same animal model to also have the possibility to investigate the switch from mania-like behavior to depressive-like behavior and vice versa. The use of viral tools and a focus on circadian rhythms and the immune system might make the creation of such animal models possible.

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Cognitive judgment bias in the psychostimulant-induced model of mania in rats

Cited by 21 publications

References 48 publications

Effects of optimism on motivation in rats

Effects of optimism on motivation in rats

Making Decisions under Ambiguity: Judgment Bias Tasks for Assessing Emotional State in Animals

Animal models for bipolar disorder: from bedside to the cage

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