Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children

Heim, Stefan; Grande, M.; Meffert, Elisabeth; Eickhoff, Simon B.; Schreiber, Helen; Kukolja, Juraj; Shah, N. Jon; Huber, Walter; Amunts, Katrin

doi:10.1016/j.neuroimage.2010.07.009

Cited by 23 publications

(14 citation statements)

References 92 publications

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“…Task specialisation between the left and right hemispheres can be associated with cerebral asymmetry in anatomy, neurotransmitter expression and inter-hemispheric signalling 29–31. A high degree of lateralisation in function may result in, or be influenced by, higher level cognitive function 32. Abnormalities in cerebral asymmetry and inter-hemispheric signalling have been associated with developmental and behavioural problems such as ADHD,4 so related difficulties may help explain our findings.…”

Section: Discussionmentioning

confidence: 64%

Laterality, hand control and scholastic performance: a British birth cohort study

et al. 2012

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ObjectivesTo use simple measures of laterality and hand control that can identify a greater risk of poorer scholastic ability, potentially signalling suboptimal hemispheric lateralisation.DesignAnalysis of material from a birth cohort study.SettingMembers of the National Child Development Study, a British birth cohort study following people born in 1958.Participants10 612 children who undertook tests at age 11 years.Primary outcome measuresTeacher-administered tests of non-verbal general ability, verbal general ability, reading comprehension and mathematics.ResultsLinear regression produced associations (and 95% CIs) with tests of verbal general ability, non-verbal general ability, reading comprehension and mathematics scores for the lowest third (compared with highest) of a left-hand control test involving picking up matches of −1.21 (−1.73 to −0.68; p<0.001), −0.72 (−1.14 to −0.29; p=0.001), −0.70 (−1.06 to −0.35; p<0.001) and −1.32 (−1.90 to −0.73; p<0.001). Among those in the lowest third of the right-hand control test score, mixed-handedness compared with right-handedness was associated with poorer scholastic performance, with regression coefficients (and 95% CIs; p values) of 1.90 (−3.01 to −0.80; p=0.001), −1.25 (−2.15 to −0.35; p=0.007), −1.28 (2.04 to −0.53; p=0.001) and −1.33 (−2.53 to −0.13; p=0.030). The estimates are for a point change in the scholastic test scores, after adjustment for sex, left-hand motor function and social class. Statistically significant associations with mixed-handedness were only observed for the lowest third of right-hand motor function.ConclusionsMeasures involving poorer left-hand motor function may represent useful markers of reduced cognitive function possibly reflecting suboptimal hemispheric lateralisation. Crude measures of laterality such as reported non-right-handedness may be more useful for research when combined with measures of motor function.

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Section: Discussionmentioning

confidence: 64%

Laterality, hand control and scholastic performance: a British birth cohort study

et al. 2012

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“…The cytoarchitecture and white matter connectivity of the angular gyrus are well suited to perform the heteromodal integrative functions required for a process like conceptual combination ( comparative anatomic studies suggest that it has undergone a prominent evolutionary expansion in humans relative to monkeys (Orban et al, 2004;Sherwood et al, 2008;Hill et al, 2010). Functionally, it is one of the most commonly activated regions in studies of lexical-semantic memory (Binder et al, 2009), and it has been specifically implicated in the processing of sentences compared with word lists (Friederici et al, 2000;Vandenberghe et al, 2002;Humphries et al, 2006), with an activation profile that specifically correlates with the number of sequentially coherent words in a sentence (Pallier et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…With typical left-hemisphere language dominance in righthanders, lexical-semantic processing may rely more consistently on the left angular gyrus across subjects for all types of combinatorial stimuli. However for some participants, an advantage may be gained by additionally recruiting the right angular gyrus and thus, the right angular gyrus may be more sensitive to individual differences across subjects in lexical-semantic processing (Heim et al, 2010).…”

Section: Figurementioning

confidence: 99%

Converging Evidence for the Neuroanatomic Basis of Combinatorial Semantics in the Angular Gyrus

Bonner²,

et al. 2015

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Human thought and language rely on the brain's ability to combine conceptual information. This fundamental process supports the construction of complex concepts from basic constituents. For example, both "jacket" and "plaid" can be represented as individual concepts, but they can also be integrated to form the more complex representation "plaid jacket." Although this process is central to the expression and comprehension of language, little is known about its neural basis. Here we present evidence for a neuroanatomic model of conceptual combination from three experiments. We predicted that the highly integrative region of heteromodal association cortex in the angular gyrus would be critical for conceptual combination, given its anatomic connectivity and its strong association with semantic memory in functional neuroimaging studies. Consistent with this hypothesis, we found that the process of combining concepts to form meaningful representations specifically modulates neural activity in the angular gyrus of healthy adults, independent of the modality of the semantic content integrated. We also found that individual differences in the structure of the angular gyrus in healthy adults are related to variability in behavioral performance on the conceptual combination task. Finally, in a group of patients with neurodegenerative disease, we found that the degree of atrophy in the angular gyrus is specifically related to impaired performance on combinatorial processing. These converging anatomic findings are consistent with a critical role for the angular gyrus in conceptual combination.

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“…For example, aSMG (but not pSMG) is active during the conversion of orthographic input to licit phonological information (e.g., Booth et al, 2002; Hartwigsen et al, 2010; Richlan et al, 2009; Tan et al, 2005; see also Heim et al, 2010, discussed below). In IFG, indices of print exposure have been functionally related to this area’s role in print-speech convergence, such that greater print exposure was related to greater functional overlap during the processing of spoken and written sentences (Shankweiler et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Individual differences in decoding skill, print exposure, and cortical structure in young adults

Johns

Jahn

Jones

et al. 2018

Language, Cognition and Neuroscience

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This exploratory study investigated relations between individual differences in cortical grey matter structure and young adult readers’ cognitive profiles. Whole-brain analyses revealed neuroanatomical correlations with word and nonword reading ability (decoding), and experience with printed matter. Decoding was positively correlated with grey matter volume (GMV) in left superior temporal sulcus, and thickness (GMT) in right superior temporal gyrus. Print exposure was negatively correlated with GMT in left inferior frontal gyrus (pars opercularis) and left fusiform gyrus (including the visual word form area). Both measures also correlated with supramarginal gyrus (SMG), but in spatially distinct subregions: decoding was positively associated with GMV in left anterior SMG, and print exposure was negatively associated with GMT in left posterior SMG. Our comprehensive approach to assessment both confirms and refines our understanding of the novel relation between the structure of pSMG and proficient reading, and unifies previous research relating cortical structure and reading skill.

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Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children

Cited by 23 publications

References 92 publications

Laterality, hand control and scholastic performance: a British birth cohort study

Laterality, hand control and scholastic performance: a British birth cohort study

Converging Evidence for the Neuroanatomic Basis of Combinatorial Semantics in the Angular Gyrus

Individual differences in decoding skill, print exposure, and cortical structure in young adults

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