Cognitive Memory Comparison Between Tinnitus and Normal Cases Using Event-Related Potentials

Asadpour, Abdoreza; Alavi, Azin; Jahed, Mehran; Mahmoudian, Saeid

doi:10.3389/fnint.2018.00048

Cited by 14 publications

(14 citation statements)

References 16 publications

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“…Previous MMN and equivalent studies (Weisz et al, 2004;Holdefer et al, 2013;Mahmoudian et al, 2013;Asadpour et al, 2018;El-Minawi et al, 2018;Mohebbi et al, 2019b) have varied according to the type of deviant, the paradigm used, control matching for hearing loss, and, importantly, whether stimulus frequencies were standardized or targeted to subjects' tinnitus. Studies with nontargeted stimulus frequencies have reported slightly smaller MMN responses to deviants of all types tested (Holdefer et al, 2013;Mahmoudian et al, 2013), and minor differences in P300 oddball responses to auditory and visual stimuli (Asadpour et al, 2018). At the audiometric (not tinnitus) edge frequency, tinnitus patients showed larger MMN responses (in the N1 timeframe) to downward frequency deviants than hearing unmatched controls (Weisz et al, 2004), and unchanged responses one octave lower.…”

Section: Previous Mmn Studies In Tinnitusmentioning

confidence: 99%

Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses

et al. 2019

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We tested the popular, unproven theory that tinnitus is caused by resetting of auditory predictions toward a persistent low-intensity sound. Electroencephalographic mismatch negativity responses, which quantify the violation of sensory predictions, to unattended tinnitus-like sounds were greater in response to upward than downward intensity deviants in 26 unselected chronic tinnitus subjects with normal to severely impaired hearing, and in 15 acute tinnitus subjects, but not in 26 hearing and age-matched controls (p Ͻ 0.001, receiver operator characteristic, area under the curve, 0.77), or in 20 healthy and hearing-impaired controls presented with simulated tinnitus. The findings support a prediction resetting model of tinnitus generation, and may form the basis of a convenient tinnitus biomarker, which we name Intensity Mismatch Asymmetry, which is usable across species, is quick and tolerable, and requires no training.

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Section: Previous Mmn Studies In Tinnitusmentioning

confidence: 99%

Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses

et al. 2019

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“…Concerning P2, reduced amplitudes [ 89 ] and higher latencies [ 93 , 98 ] have been found in tinnitus patients in several studies. Increased latency of P3 without amplitude change was found in tinnitus patients in the majority of studies [ 73 , 93 , 99 ], while other studies found that the amplitude of P3 in tinnitus patients was significantly lower than in controls and there is no difference in latency [ 89 , 91 , 92 , 100 , 101 ]. Furthermore, larger P3 amplitudes along with prolonged latency were observed in individuals with tinnitus [ 96 ].…”

Section: Electrophysiological Methodsmentioning

confidence: 99%

Objective Detection of Tinnitus Based on Electrophysiology

Fan

2022

Brain Sciences

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Tinnitus, a common disease in the clinic, is associated with persistent pain and high costs to society. Several aspects of tinnitus, such as the pathophysiology mechanism, effective treatment, objective detection, etc., have not been elucidated. Any change in the auditory pathway can lead to tinnitus. At present, there is no clear and unified mechanism to explain tinnitus, and the hypotheses regarding its mechanism include auditory plasticity theory, cortical reorganization theory, dorsal cochlear nucleus hypothesis, etc. Current theories on the mechanism of tinnitus mainly focus on the abnormal activity of the central nervous system. Unfortunately, there is currently a lack of objective diagnostic methods for tinnitus. Developing a method that can detect tinnitus objectively is crucial, only in this way can we identify whether the patient really suffers from tinnitus in the case of cognitive impairment or medical disputes and the therapeutic effect of tinnitus. Electrophysiological investigations have prompted the development of an objective detection of tinnitus by potentials recorded in the auditory pathway. However, there is no objective indicator with sufficient sensitivity and specificity to diagnose tinnitus at present. Based on recent findings of studies with various methods, possible electrophysiological approaches to detect the presence of tinnitus have been summarized. We analyze the change of neural activity throughout the auditory pathway in tinnitus subjects and in patients with tinnitus of varying severity to find available parameters in these methods, which is helpful to further explore the feasibility of using electrophysiological methods for the objective detection of tinnitus.

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“…P3 is reported to be altered in individuals with tinnitus, which indicates attentional dysfunction. 20 21 22 23 24 25…”

Section: Introductionmentioning

confidence: 99%

“…There have been shreds of evidence that tinnitus affects either or both the sensory and cognitive components of CAEPs, suggesting a difference in the way sound is being processed. 20 21 22 23 24 25 26 27 28 In vitro animal studies 16 have shown that the hyperactive neural firings decrease as a result of RIT. However, there are no neurophysiological studies reported on humans following RIT or educational counselling.…”

Section: Introductionmentioning

confidence: 99%

Cortical Reorganization Following Psychoeducational Counselling and Residual Inhibition Therapy (RIT) in Individuals with Tinnitus

Vasudevan

Palaniswamy

Ramaswamy

et al. 2022

Int Arch Otorhinolaryngol

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Introduction Psychoeducational counselling and residual inhibition therapy (RIT) are traditional approaches used in many clinics to manage tinnitus. However, neurophysiological studies to evaluate posttreatment perceptual and functional cortical changes in humans are scarce. Objectives The present study aims to explore whether cortical auditory-evoked potentials (CAEPs; N1 and P3) reflect the effect of modified RIT and psychoeducational counselling, and whether there is a correlation between the behavioral and electrophysiological measures. Methods Ten participants with continuous and bothersome tinnitus underwent a session of psychoeducational counselling and modified RIT. Perceptual measures and CAEPs were recorded pre- and posttreatment. Further, the posttreatment measures were compared with age and gender-matched historical control groups. Results Subjectively, 80% of the participants reported a reduction in the loudness of their tinnitus. Objectively, there was a significant reduction in the posttreatment amplitude of N1 and P3, with no alterations in latency. There was no correlation between the perceived difference in tinnitus loudness and the difference in P3 amplitude (at Pz). Conclusion The perceptual and functional (as evidenced by sensory, N1, and cognitive, P3 reduction) changes after a single session of RIT and psychoeducational counselling are suggestive of plastic changes at the cortical level. The current study serves as preliminary evidence that event-related potentials (ERPs) can be used to quantify the physiological changes that occur after the intervention for tinnitus.

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Cognitive Memory Comparison Between Tinnitus and Normal Cases Using Event-Related Potentials

Cited by 14 publications

References 16 publications

Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses

Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses

Objective Detection of Tinnitus Based on Electrophysiology

Cortical Reorganization Following Psychoeducational Counselling and Residual Inhibition Therapy (RIT) in Individuals with Tinnitus

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