Cognitive or daily stress association with headache and pain induction in migraine and tension-type headache patients: a systematic review

Viero, Fernanda Tibolla; Rodrigues, Patrícia; Trevisan, Gabriela

doi:10.1080/14737175.2022.2041414

Cited by 8 publications

(8 citation statements)

References 51 publications

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“…Migraine has a higher prevalence in females and negatively affects the quality of life of patients ( Feigin et al, 2020 ). Stress is a common trigger reported in migraine patients, but the underlying mechanisms are poorly understood ( Kelman, 2007 ; Viero et al, 2022a ). Indeed, different types of stress, such as repetitive restrain stress paradigm, social defeat stress, chronic variable stress, and early life stress have been used as models of migraine-like behavior in animals ( Kaufmann and Brennan, 2018 ; Avona et al, 2020a ; Eller et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…NST animals were placed in the sound chamber for 30 min, but without exposure to the sound stimulus on the same days as the stressed group. Animals were placed 4–5 per cage, and the cage was placed 25 cm from a speaker that emitted four pure tones (5, 11, 15, and 19 kHz), whose amplitudes vary independently through time, from 20–110 dB sound pressure level at random times each minute, lasting for five or 10 s. Animals were exposed to the stressor for three nonconsecutive days ( Kelman, 2007 ; Kelman, 2007 ; Gazerani and Cairns, 2020 ; Viero et al, 2022a ), for 30 min each day. Day 1 post-stress induction described in our study, corresponds to day 5 (considering the beginning of the test).…”

Section: Methodsmentioning

confidence: 99%

“…Migraine attacks are elicited by a variety of agents, including stress induction ( Kelman, 2007 ). Stress is the most common trigger reported in migraine patients; it can also increase the duration of the crisis and contributes to chronic migraine development ( Kelman, 2007 ; Viero et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

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Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

et al. 2022

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Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized nociception and anxiety-related symptoms after the induction of sound stress in mice. C57BL/6 mice (20–30 g) were exposed to unpredictable sound stress for 3 days, nonconsecutive days. We observed enhanced plasma corticosterone levels on day 1 after stress induction. First, 7 days after the last stress session, mice developed hind paw and periorbital mechanical allodynia, grimacing pain behavior, anxiety-like symptoms, and reduced exploratory behavior. The nociceptive and behavioral alterations detected in this model were mostly shown in female stressed mice at day 7 post-stress. In addition, on day 7 post-stress nociception, these behaviors were consistently abolished by the CGRP receptor antagonist olcegepant (BIBN4096BS, 100 mg/kg by intraperitoneal route) in female and male stressed mice. We also demonstrated an increase in interleukine-6 (IL-6), tumor necrosis factor (TNF-α), and CGRP levels in stressed mice plasma, with female mice showing higher levels compared to male mice. This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine-inducing pain.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

et al. 2022

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“…Migraine has a higher prevalence in female and negatively affects the quality of life of patients [21]. Stress is a common trigger reported in migraine patients, but the underlying mechanisms are poorly understood [30,53]. Indeed, different types of stress, such as repetitive restrain stress paradigm, social defeat stress, chronic variable stress, and early life stress have been used as models of migraine-like behavior in animals [8,20].…”

Section: Discussionmentioning

confidence: 99%

“…The migraine attacks are elicited by a variety of agents, such as stress induction and others [30]. Stress is the most common trigger reported in migraine patients, also it can raise the duration of the crisis and the induction of chronic migraine [30,53]. Thus, different stress models have been used to induce migraine-like behaviors (periorbital/hind paw mechanical allodynia, grimacing pain behavior, and anxiety-related symptoms) in mice to better study the mechanisms involved in this painful disease.…”

Section: Introductionmentioning

confidence: 99%

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

Viero

Rodrigues

Frare

et al. 2022

Preprint

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Background and purpose Migraine represents one of the major causes of disability worldwide and is more prevalent in women, it is also related to anxiety symptoms. Stress is a frequently reported trigger in migraine patients, such as sound stress, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized the nociception and anxiety-related symptoms after the induction of unpredictable sound stress in mice. Experimental approach C57BL/6 mice (20-30 g) were exposed to unpredictable sound stress for 3 days. Mainly, after 7 days of the last stress session mice developed hind paw, periorbital mechanical allodynia, grimacing pain behavior, anxiety-like, and reduced exploratory behavior. Key results These nociceptive and behavioral alterations detected in this model were shown mostly in female stressed mice. Besides, 7th-day post-stress nociception, these behaviors were consistently abolished by CGRP receptor antagonist olcegepant (BIBN4096BS, 100mg/kg by intraperitoneal route) until 3 h after treatment in stressed mice. In addition, we demonstrated an increase in levels of IL-6 and TNF-α and CGRP levels in stressed mice plasma, with female with higher levels when compared to male mice. Conclusions and implications This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine pain, which appear to be distinct in male and female mice.

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The Role of the Autonomic Nervous System in Headache: Biomarkers and Treatment

Gevirtz

2022

Curr Pain Headache Rep

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Purpose of Review In this review, the role of the autonomic nervous system in tension-type headache and migraine is reviewed. Recent Findings A pathophysiological model for tension-type headache is proposed that is compatible with most physiological and behavioral literature. Summary A treatment protocol is described that follows from this model. For migraine, incorporating autonomic factors into the pathophysiology offers rationales for behavioral interventions that have been shown to be useful in migraine treatment and a biofeedback protocol is proposed.

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Cognitive or daily stress association with headache and pain induction in migraine and tension-type headache patients: a systematic review

Cited by 8 publications

References 51 publications

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

The Role of the Autonomic Nervous System in Headache: Biomarkers and Treatment

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