Cognitive outcome after awake surgery for tumors in language areas

Santini, Barbara; Talacchi, Andrea; Squintani, Giovanna; Casagrande, Francesca; Capasso, Rita; Miceli, Gabriele

doi:10.1007/s11060-012-0817-4

Cited by 90 publications

(94 citation statements)

References 19 publications

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“…, Santini et al . , Satoer et al . )—all of which are abilities that could affect typing speed and, hence, writing fluency.…”

Section: Discussionmentioning

confidence: 99%

“…One can only speculate what factors explain the differences in typing speed found between the LGG patients and the reference group. It is known that LGG patients may present with deficits in cognitive functions such as executive functions, working memory and processing speed (e.g., Talacchi et al 2011, Santini et al 2012, Satoer et al 2012)-all of which are abilities that could affect typing speed and, hence, writing fluency. In the present study (which is part of a project focusing on effects on language ability following LGG surgery), only tests of lexical retrieval (naming and verbal word fluency) were used.…”

Section: Typing Speed Affects Writing Fluencymentioning

confidence: 99%

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Writing fluency in patients with low‐grade glioma before and after surgery

Antonsson

Johansson

Hartelius

et al. 2018

Intl J Lang & Comm Disor

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BackgroundLow‐grade glioma (LGG) is a type of brain tumour often situated in or near areas involved in language, sensory or motor functions. Depending on localization and tumour characteristics, language or cognitive impairments due to tumour growth and/or surgical resection are obvious risks. One task that may be at risk is writing, both because it requires intact language and memory function and because it is a very complex and cognitively demanding task. The most commonly reported language deficit in LGG patients is oral lexical‐retrieval difficulties, and poor lexical retrieval would be expected to affect writing fluency.AimsTo explore whether writing fluency is affected in LGG patients before and after surgery and whether it is related to performance on tasks of oral lexical retrieval.Methods & ProceduresTwenty consecutive patients with presumed LGG wrote a narrative and performed a copy task before undergoing surgery and at 3‐month follow‐up using keystroke‐logging software. The same tasks were performed by a reference group (N = 31). The patients were also tested using the Boston Naming Test (BNT) and word‐fluency tests before and after surgery. Writing fluency was compared between the patients and the reference group, and between the patients before and after surgery. Relationships between performance on tests of oral lexical retrieval and writing fluency were investigated both before and after surgery.Outcome & ResultsDifferent aspects of writing fluency were affected in the LGG patients both before and after surgery. However, when controlling for the effect of typing speed, the LGG group differed significantly from the reference group only in the proportion of pauses within words. After surgery, a significant decline was seen in production rate and typing speed in the narrative task, and a significant increase was seen in pauses before words. Strong positive relationships were found between oral lexical retrieval and writing fluency both before and after surgery.Conclusions & ImplicationsAlthough aspects of writing fluency were affected both before and after surgery, the results indicate that typing speed is an important factor behind the pre‐surgery differences. However, the decline in overall productivity and the increase in pauses before words after surgery could be related to a lexical deficit. This is supported by the finding that oral lexical‐retrieval scores were strongly correlated with writing fluency. However, further exploration is needed to identify the language and cognitive abilities affecting writing processes in LGG patients.

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“…, Santini et al . , Satoer et al . )—all of which are abilities that could affect typing speed and, hence, writing fluency.…”

Section: Discussionmentioning

confidence: 99%

Section: Typing Speed Affects Writing Fluencymentioning

confidence: 99%

Writing fluency in patients with low‐grade glioma before and after surgery

Antonsson

Johansson

Hartelius

et al. 2018

Intl J Lang & Comm Disor

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“…De gieter smeert een boterham -The watering-can prepares a sandwich). This task can be used for temporal cortical and subcortical areas (Bello et al, 2007;Bertani et al, 2009;Pereira et al, 2009;Santini et al, 2012). The sentences were based on BOX part 6 of Visch-Brink and Bajema (2001).…”

Section: B22 Judgment Of Semantically Anomalous and Correct Sentencesmentioning

confidence: 99%

The Dutch Linguistic Intraoperative Protocol: A valid linguistic approach to awake brain surgery

Witte¹,

Satoer²,

Espesser³

et al. 2015

Brain and Language

116

115

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Intraoperative direct electrical stimulation (DES) is increasingly used in patients operated on for tumours in eloquent areas. Although a positive impact of DES on postoperative linguistic outcome is generally advocated, information about the neurolinguistic methods applied in awake surgery is scarce. We developed for the first time a standardised Dutch linguistic test battery (measuring phonology, semantics, syntax) to reliably identify the critical language zones in detail. A normative study was carried out in a control group of 250 native Dutch-speaking healthy adults. In addition, the clinical application of the Dutch Linguistic Intraoperative Protocol (DuLIP) was demonstrated by means of anatomo-functional models and five case studies. A set of DuLIP tests was selected for each patient depending on the tumour location and degree of linguistic impairment. DuLIP is a valid test battery for pre-, intraoperative and postoperative language testing and facilitates intraoperative mapping of eloquent language regions that are variably located.

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“…Approximately one-quarter of patients with LGGs report serious problems with their neurocognitive functioning, particularly memory concentration, 34 language, and executive functions, 38,40,43,48 including at presentation. 23 Previous studies have suggested that many patients with LGG suffer from neurocognitive deficits and compromised health-related quality of life (HRQoL).…”

mentioning

confidence: 99%

Improvement in cognitive function after surgery for low-grade glioma

Barzilai¹,

Moshe²,

Sitt³

et al. 2019

Journal of Neurosurgery

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OBJECTIVE Cognition is a key component in health-related quality of life (HRQoL) and is currently incorporated as a major parameter of outcome assessment in patients treated for brain tumors. The effect of surgery on cognition and HRQoL remains debatable. The authors investigated the impact of resection of low-grade gliomas (LGGs) on cognition and the correlation with various histopathological markers. METHODS A retrospective analysis of patients with LGG who underwent craniotomy for tumor resection at a single institution between 2010 and 2014 was conducted. Of 192 who underwent resective surgery for LGG during this period, 49 had complete pre- and postoperative neurocognitive evaluations and were included in the analysis. These patients completed a full battery of neurocognitive tests (memory, language, attention and working memory, visuomotor organization, and executive functions) pre- and postoperatively. Tumor and surgical characteristics were analyzed, including volumetric measurements and histopathological markers (IDH, p53, GFAP). RESULTS Postoperatively, significant improvement was found in memory and executive functions. A subgroup analysis of patients with dominant-side tumors, most of whom underwent intraoperative awake mapping, revealed significant improvement in the same domains. Patients whose tumors were on the nondominant side displayed significant improvement only in memory functions. Positive staining for p53 testing was associated with improved language function and greater extent of resection in dominant-side tumors. GFAP positivity was associated with improved memory in patients whose tumors were on the nondominant side. No correlation was found between cognitive outcome and preoperative tumor volume, residual volume, extent of resection, or IDH1 status. CONCLUSIONS Resection of LGG significantly improves memory and executive function and thus is likely to improve functional outcome in addition to providing oncological benefit. GFAP and pP53 positivity could possibly be associated with improved cognitive outcome. These data support early, aggressive, surgical treatment of LGG.

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Cognitive outcome after awake surgery for tumors in language areas

Cited by 90 publications

References 19 publications

Writing fluency in patients with low‐grade glioma before and after surgery

Writing fluency in patients with low‐grade glioma before and after surgery

The Dutch Linguistic Intraoperative Protocol: A valid linguistic approach to awake brain surgery

Improvement in cognitive function after surgery for low-grade glioma

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