Cognitive Outcomes After Infant Spinal Anesthesia

Nemergut, Michael E.; Crow, Sheri; Flick, Randall P.

doi:10.1213/ane.0000000000000343

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…Sedation, if used correctly, will increase patient satisfaction (16). Amnesia, which is primarily one of the main goals of anesthesia, decreases the stress response in the peri and post-operative periods (17). Amnesia induced by amnestic drugs could reduce stress levels in post-operative time (18).…”

Section: Introductionmentioning

confidence: 99%

Post-traumatic stress and awareness in patient with traumatic lower limb surgery by neuraxial anesthesia: A randomized clinical trial

Hashemian¹,

Zandrahimi²,

Mirafzal³

et al. 2023

Arch Psych Psych

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Aim of the studyAnesthesia decreases brain cognitive function, memory and pain, and also leads to the loss of consciousness. In this study, midazolam and propofol-sedated trauma patients undergoing lower limb surgery were evaluated for stress levels after neuraxial anesthesia.Subject or material and methodsThis double-blind randomized clinical trial was conducted on patients with lower extremity fractures due to trauma, who were candidates of elective lower extremity orthopedic surgery. Patients were randomly divided into two groups of propofol-sedated patients (n=110) and midazolam-sedated patients (n=110) after neuraxial anesthesia. Then, all patients underwent spinal anesthesia using 3 ml of 0.5% bupivacaine (3 mg/kg). Propofol (25-75 µg/kg/minute) was infused, and 1-2 mg of midazolam was injected PRN until patients reached the score of 3 on the Modified Observers' Assessment of Alertness/ Sedation Scale (MOAA/S).ResultsPreoperative sedation/alertness scores of patients in the two groups did not differ significantly from one another. Penetrating memories in the midazolam group was higher than the propofol group (P<0.05). Personal relationship problem was more significant in the midazolam group than the propofol group (P<0.05). Inability in controlling emotional feelings was higher in the midazolam group compared to the propofol group (P<0.001).DiscussionOur findings indicated that a sub-hypnotic dose of propofol provided superior sedation and amnesia compared to midazolam. Aspects of stress, including penetrating memories, personal relationship problems, inability to control emotional feelings, and lack of depression during spinal anesthesia were better managed by propofol compared to midazolam.ConclusionsPropofol infusion was better in decreasing stress levels after surgery compared to midazolam.

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Section: Introductionmentioning

confidence: 99%