Cognitive performance and the thymus among HIV-infected subjects receiving HAART

Míguez‐Burbano, Maria José; Lewis, John E.; Moreno, J.L.; Fishman, Joel E.

doi:10.2147/btt.s1753

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…However, thymus size could not be explained by any sociodemographic characteristics (i.e., age or gender). As previously reported, thymus size differed between hazardous and non-hazardous alcohol users [15]. …”

Section: Platelets and Thymussupporting

confidence: 53%

The role of alcohol on platelets, thymus and cognitive performance among HIV-infected subjects: Are they related?

et al. 2009

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Our objective was to evaluate whether thrombocytopenia and small thymus volume, which may be associated with hazardous alcohol consumption, are predictors of cognitive performance after highly-active antiretroviral treatment (HAART). To achieve this goal 165 people living with HIV starting HAART underwent thymus magnetic resonance imaging, cognitive (HIV Dementia Score [HDS] and the California Verbal Learning Test [CVLT]), immune and laboratory assessments at baseline and after 6 months of HAART. At baseline, hazardous alcohol consumption was significantly correlated with both thymus size (r = −0.44, p = 0.003) and thrombocytopenia (r = 0.28, p = 0.001). Of interest, thrombocytopenic patients were characterized by a smaller thymus size. Individuals with and without cognitive impairment differed in alcohol consumption, platelet counts and thymus size, suggesting that they may be risk factors for neurological abnormalities. In fact, after HAART hazardous alcohol use associations with thrombocytopenia were related to cognitive decline (learning = −0.2 ± 0.8, recall = −0.3 ± 0.1 and HDS = −0.5). This contrasted with improvements on every cognitive measure (learning = 1.6 ± 0.3, p = 0.0001, recall = 2.2 ± 0.4, p = 0.0001 and HDS = 1.0, p = 0.05) in those with neither alcohol use nor thrombocytopenia. In adjusted analyses for sociodemographics, adherence and immune measurements, reduced thymus size was associated with a 90% and thrombocytopenia with a 70% increase in the risk of scoring in the demented range after HAART (RR = 1.9, p < 0.05 and RR = 1.7, p = 0.03) and with low CLVT scores (thymus volume RR = 2.0, p = 0.04, chronic alcohol use p = 0.05 and thrombocytopenia p = 0.06). Thymus volume and platelet counts were negatively affected by alcohol and were predictors of cognitive performance and improvements after HAART. These results could have important clinical and therapeutic implications.

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Section: Platelets and Thymussupporting

confidence: 53%

The role of alcohol on platelets, thymus and cognitive performance among HIV-infected subjects: Are they related?

et al. 2009

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“…Medication history included previous exposure to antiretrovirals as well as lipid lowering medications. These questionnaires have been used in the authors’ previous studies (Miguez-Burbano, Lewis, Moreno, & Fishman, 2008). To determine immune status and HAART effectiveness, CD4 cell counts were determined by flow cytometry per National Institute of Allergy and Infectious Diseases laboratory protocols and HIV viral load by polymerase chain reaction (COBAS Amplicor Analyzer [Roche Molecular Diagnostics, Pleasanton, CA]).…”

Section: Methodsmentioning

confidence: 99%

Alcohol and Race/Ethnicity Elicit Different Changes in Lipid Profiles in HIV-Infected Individuals Receiving Highly Active Antiretroviral Therapy

Míguez‐Burbano

Lewis

Malow³

2009

Journal of the Association of Nurses in AIDS Care

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This longitudinal study examined the impact of alcohol consumption (88 hazardous and 76 nonhazardous drinkers) and race/ethnicity on lipid profiles in individuals starting highly active antiretroviral therapy (HAART). At baseline, Whites and Hispanics had the most adverse lipid profiles, whereas Blacks had the least atherogenic. Whites and Hispanics showed higher increases in cholesterol (W = 11%; H = 6%), triglycerides (W = 40%; H = 24%), and low-density lipoprotein (10%) than Blacks (cholesterol = 4%; triglycerides = 9%; low-density lipoprotein = 4%). Hazardous alcohol consumption was correlated with increased lipids in each group. Hispanics had a clear trait risk for hypertriglyceridemia with HAART (1.9-fold) and with hazardous drinking (3.2-fold; p = .04). The highest risk for hypertriglyceridemia was found in heavy drinkers (3.75-fold; p = .05). Results underscore the importance of an alcohol/race interactive effect on HAART-associated dyslipidemia and the need for assessment and treatment of alcohol disorders.

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“…Prevention interventions for Indian couples should integrate reproductive health and alcohol use counselling at entry into care. 19 Studies have yielded conflicting results regarding alcohol's influence on HIV outcomes, particularly after Highly Active Antiretroviral Treatment (HAART). Discrepant findings may be related to confounding variables including gender, patterns of alcohol abuse and type of alcohol beverage beyond the amount consumed.…”

Section: On Treatmentmentioning

confidence: 99%

Study of Cd4 Count in Hiv Patients on Haart Therapy

Sreenivasulu¹,

S²

2016

jemds

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BACKGROUNDHIV infection has evolved into greatest pandemic in human history with more than 60 million humans currently affected by HIV virus. CD4 cell dysfunction is the hallmark of HIV disease. CD4 count is important for initiation and monitoring of ART and opportunistic infection prophylaxis, we have conducted a study on 100 HIV patients on HAART therapy whose CD4 count is < 350/MI, follows for 6 months.

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Cognitive performance and the thymus among HIV-infected subjects receiving HAART

Cited by 6 publications

References 18 publications

The role of alcohol on platelets, thymus and cognitive performance among HIV-infected subjects: Are they related?

The role of alcohol on platelets, thymus and cognitive performance among HIV-infected subjects: Are they related?

Alcohol and Race/Ethnicity Elicit Different Changes in Lipid Profiles in HIV-Infected Individuals Receiving Highly Active Antiretroviral Therapy

Study of Cd4 Count in Hiv Patients on Haart Therapy

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