Cognitive performance in antidepressant-free recurrent major depressive disorder

Albert, Kimberly; Potter, Guy G.; McQuoid, Douglas R.; Taylor, Warren D.

doi:10.1002/da.22747

Cited by 30 publications

(23 citation statements)

References 38 publications

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“…Cronbach’s alpha (CoA) was computed for each domain as a measure of internal consistency. As previously published 28 , for the adult cohort, tests in each domain included: Episodic Memory (CoA = 0.87): Logical Memory 1 and 2 from the Wechsler Memory Scale, Benton Visual Retention Test, Rey’s Verbal Learning Test (total I–V and total VII); Executive Function (CoA = 0.75): Controlled Oral Word Association (COWA) test (letters: C, F, L), Trail Making B time (reverse scored), semantic fluency (Animal Naming), Stroop Color-Word interference condition; Processing Speed (CoA = 0.70): Symbol-Digit Modality, Trail Making A time (reverse scored), Stroop Color Naming condition; Working Memory (CoA = 0.75): Digit Span forward and Digit Span backward from the Wechsler Memory Scale. …”

Section: Methodsmentioning

confidence: 96%

“…All study participants provided written informed consent. Data from the adult cohort has previously been reported 28 , 29 and we have also reported cognitive data from the geriatric cohort 20 .…”

Section: Methodsmentioning

confidence: 99%

“…Participants completed a broad battery of neuropsychological tests that assessed cognitive domains relevant to depression or aging. As previously detailed 28,32,33 , we combined tests to create composite domain variables. We created z-scores for each measure based on the performance of all participants within each age cohort and averaged the z-scores for all tests within that domain.…”

Section: Cognitive Assessmentsmentioning

confidence: 99%

“…Cronbach's alpha (CoA) was computed for each domain as a measure of internal consistency. As previously published 28 , for the adult cohort, tests in each domain included:…”

Section: Cognitive Assessmentsmentioning

confidence: 99%

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Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression

et al. 2020

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Depression is associated with markers of accelerated aging, but it is unclear how this relationship changes across the lifespan. We examined whether a brain-based measure of accelerated aging differed between depressed and never-depressed subjects across the adult lifespan and whether it was related to cognitive performance and disability. We applied a machine-learning approach that estimated brain age from structural MRI data in two depressed cohorts, respectively 170 midlife adults and 154 older adults enrolled in studies with common entry criteria. Both cohorts completed broad cognitive batteries and the older subgroup completed a disability assessment. The machine-learning model estimated brain age from MRI data, which was compared to chronological age to determine the brain–age gap (BAG; estimated age-chronological age). BAG did not differ between midlife depressed and nondepressed adults. Older depressed adults exhibited significantly higher BAG than nondepressed elders (Wald χ2 = 8.84, p = 0.0029), indicating a higher estimated brain age than chronological age. BAG was not associated with midlife cognitive performance. In the older cohort, higher BAG was associated with poorer episodic memory performance (Wald χ2 = 4.10, p = 0.0430) and, in the older depressed group alone, slower processing speed (Wald χ2 = 4.43, p = 0.0354). We also observed a statistical interaction where greater depressive symptom severity in context of higher BAG was associated with poorer executive function (Wald χ2 = 5.89, p = 0.0152) and working memory performance (Wald χ2 = 4.47, p = 0.0346). Increased BAG was associated with greater disability (Wald χ2 = 6.00, p = 0.0143). Unlike midlife depression, geriatric depression exhibits accelerated brain aging, which in turn is associated with cognitive and functional deficits.

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Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Cognitive Assessmentsmentioning

confidence: 99%

“…Cronbach's alpha (CoA) was computed for each domain as a measure of internal consistency. As previously published 28 , for the adult cohort, tests in each domain included:…”

Section: Cognitive Assessmentsmentioning

confidence: 99%

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Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression

et al. 2020

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“…In addition, other studies have reported how opioids affect memory, learning, and emotional disturbances (2, 3, 10, 11). Depression has long been associated with widespread cognitive deficits (12) which tend to worsen over a life span (13).…”

Section: Introductionmentioning

confidence: 99%

Effects of Opioid Dependence on Visuospatial Memory and Its Associations With Depression and Anxiety

et al. 2019

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Introduction: The cognitive impact of opioid dependence is rarely measured systematically in everyday clinical practice even though both patients and clinicians accept that cognitive symptoms often occur in the opioid-dependent population. There are only a few publications which utilized computerized neuropsychological tests to assess possible impairments of visuospatial memory in opioid-dependent individuals either receiving opioid replacement therapy (ORT) or during subsequent short-term abstinence and the effects of anxiety and depression.Methods: We assessed a cohort of 102 participants, comprising i) a stable opioid-dependent group receiving methadone maintenance treatment (MMT) (n = 22), ii) a stable opioid-dependent group receiving buprenorphine (BMT) (n = 20), iii) a current abstinent but previously opioid-dependent group (ABS) (n = 8), and iv) a control group who have never been dependent on opioids. The Cambridge Neuropsychological Automated Test Battery (CANTAB) neuropsychological tasks undertaken by participants included: Delayed Matching to Sample (DMS), Pattern Recognition Memory (PRM), Spatial Recognition Memory (SRM), and Paired Associate Learning (PAL) tasks. Three clinical measures were used to assess the severity of anxiety and depressive illness: Hospital Anxiety Scale-Hospital Anxiety Depression (HADA)-(HADD), Beck Depression Inventory (BDI), and Inventory of Depressive Symptomatology (self-report) (ISD-SR).Results: The methadone- and buprenorphine-treated groups showed significant impairments (p < 0.001) in visuospatial memory tasks but not the abstinent group. Impairments in visuospatial memory strongly correlated with higher mood and anxiety symptom severity scores (p < 0.001).Discussion: These results are broadly consistent with previous studies. Uniquely, though, here we report a strong relationship between visuospatial memory and depression and anxiety scores, which might suggest common illness mechanisms.

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Executive Dysfunction in Depressive Disorders

Rosselli

Lang

Arruda

2019

Dysexecutive Syndromes

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Cognitive performance in antidepressant-free recurrent major depressive disorder

Cited by 30 publications

References 38 publications

Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression

Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression

Effects of Opioid Dependence on Visuospatial Memory and Its Associations With Depression and Anxiety

Executive Dysfunction in Depressive Disorders

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