Cognitive performance in rats differing in their inborn anxiety.

Ohl, Frauke; Roedel, Angelika; Storch, Corinna; Holsboer, Florian; Landgraf, Rainer

doi:10.1037/0735-7044.116.3.464

Cited by 46 publications

(35 citation statements)

References 33 publications

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“…Selective breeding of Wistar rats with high and low anxiety in the plus-maze test can provide strains that differ in many respects (Liebsch et al 1998). Anxiety-related behaviour in these strains is, however, not different after habituation, and therefore the initial differences have been attributed to differential cognitive processing (Ohl et al 2002). On the other hand, in specific conditions the anxiolytic-like changes in behaviour in the plus-maze test are at odds with predictions to such an extent that entries into open arms have been taken as measures of "behavioural disinhibition" (Olausson et al 1999) or "index of impulsivity" (Ueno et al 2002) instead of the traditional "anxiolytic".…”

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confidence: 88%

Long-term partial 5-HT depletion: interference of anxiety and impulsivity?

Harro

2002

Psychopharmacology

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confidence: 88%

Long-term partial 5-HT depletion: interference of anxiety and impulsivity?

Harro

2002

Psychopharmacology

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“…Moreover, gene-environment interactions may influence habituation processes and may affect adaptive capacities, as can be seen in inbred or selectively bred rodent strains. For example, so-called LAB-rats (Low Anxiety Behaviour) and C57BL/6 mice initially show non-anxious behaviour in a novel environment and reveal no further habituation during repeated exposure, while HAB-rats (High Anxiety Behaviour) as well as DBA/2 mice show initially high anxious behaviour, but reveal rapid habituation during repeated exposure [13], [21].…”

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confidence: 99%

Not All Mice Are Equal: Welfare Implications of Behavioural Habituation Profiles in Four 129 Mouse Substrains

et al. 2012

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Safeguarding the welfare of animals is an important aim when defining housing and management standards in animal based, experimental research. While such standards are usually defined per animal species, it is known that considerable differences between laboratory mouse strains exist, for example with regard to their emotional traits. Following earlier experiments, in which we found that 129P3 mice show a lack of habituation of anxiety related behaviour after repeated exposure to an initially novel environment (non-adaptive profile), we here investigated four other 129 inbred mouse substrains (129S2/SvPas, 129S2/SvHsd (exp 1); 129P2 and 129X1 (exp 2)) on habituation of anxiety related behaviour. Male mice of each strain were repeatedly placed in the modified hole board test, measuring anxiety-related behaviour, exploratory and locomotor behaviour. The results reveal that all four substrains show a lack of habituation behaviour throughout the period of testing. Although not in all of the substrains a possible confounding effect of general activity can be excluded, our findings suggest that the genetic background of the 129 substrains may increase their vulnerability to cope with environmental challenges, such as exposure to novelty. This vulnerability might negatively affect the welfare of these mice under standard laboratory conditions when compared with other strains. Based on our findings we suggest to consider (sub)strain-specific guidelines and protocols, taking the (subs)train-specific adaptive capabilities into account.

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“…For this study, we used a modified hole board (mHB) task, which is a visuospatial task that allows for the simultaneous evaluation of different cognitive processes and other behavioural dimensions, such as avoidance behaviour, risk assessment, exploration, and locomotion over time (Ohl et al, 2003; Ohl et al, 2002; van der Kooij, Ohl, Arndt, Kavelaars, van Bel, Heijnen, 2010). …”

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Impact of anxiety profiles on cognitive performance in BALB/c and 129P2 mice

Salomons

Arndt

Ohl

2012

Cogn Affect Behav Neurosci

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It has been suggested over the decades that dysfunctional anxiety may be caused by distinct alterations in cognitive processing. To learn more about the relation between anxiety and cognitive functioning, two mouse strains that display either adaptive (BALB/c) or nonadaptive (129P2) anxiety, as reflected by their ability to habituate when repeatedly exposed to a novel environment, were tested for their cognitive performance in the modified hole board (mHB) task. In general, both strains showed successful acquisition of the task. The initially more anxious BALB/c mice revealed rapid habituation to the test setup, followed by decreased long-term and short-term memory errors across the experimental period and fast relearning after reversal of the task. By contrast, the nonadaptive 129P2 mice made more short-term memory errors and performed worse than the BALB/c animals after reversal of the test. The results confirm the proposed interaction of anxiety and cognition: In BALB/c mice, adaptive characteristics of anxiety were paralleled by more successful cognitive performance, while in 129P2 mice nonadaptive anxiety-related behaviour was accompanied by a higher level of short-term memory errors and less cognitive flexibility. Moreover, these results support our hypothesis that the nonadaptive anxiety phenotype in 129P2 mice may be the result of impaired cognitive control of emotional processes, resulting in impaired behavioural flexibility, for example in response to novelty.

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Cognitive performance in rats differing in their inborn anxiety.

Cited by 46 publications

References 33 publications

Long-term partial 5-HT depletion: interference of anxiety and impulsivity?

Long-term partial 5-HT depletion: interference of anxiety and impulsivity?

Not All Mice Are Equal: Welfare Implications of Behavioural Habituation Profiles in Four 129 Mouse Substrains

Impact of anxiety profiles on cognitive performance in BALB/c and 129P2 mice

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