Cognitive performance in women with fibromyalgia: A case-control study

Heredia-Torres, Marta Pérez de; Huertas‐Hoyas, Elisabet; Máximo-Bocanegra, Nuria; Palacios‐Ceña, Domingo; Fernández‐de‐las‐Peñas, César

doi:10.1111/1440-1630.12292

Cited by 14 publications

(14 citation statements)

References 36 publications

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“…Other evidence-based outcome assessments included the Occupational Performance History Interview (OPHI-II) ( n =3; 5.8%) and the Assessment of Pain and Occupational Performance (POP) ( n =2; 3.8%). The following assessment methods were mentioned in only one source: the Functional Independence Measure (FIM) [ 60 ]; the Milliken Activities of Daily Living Scale (MAS) [ 47 ]; the Assessment of Motor and Process Skills (AMPS) [ 75 ]; the Assessment of Life Habits Questionnaire (LIFE-H) [ 68 ]; the Impact on Participation and Autonomy (IPA) [ 58 ]; and the Pain and Functional Performance Assessment (PFPA) [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Occupational Therapy’s Unique Contribution to Chronic Pain Management: A Scoping Review

Lagueux

Dépelteau

Masse

2018

Pain Research and Management

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Occupational therapy (OT) makes a unique contribution to chronic pain (CP) management due to its overarching focus on occupation. The aim of this scoping review was to describe current knowledge about this contribution by documenting OT roles, models, assessments, and intervention methods used with adults living with CP. A systematic search exploring 10 databases and gray literature from 2006 to 2017 was conducted. Fifty-two sources were retained and analysed. Results bring forward the main role of OT being improving activities and participation (76.9 %), the Canadian Model of Occupational Performance (9.6 %), and the Canadian Occupational Performance Measure (21.2 %). Within the 30 reported interventions, 73.3% related directly to the person, 20% pertained to occupation (activities and participation), and 6.7% addressed environmental factors. The distinction and complementarity between the bottom-up and the top-down approaches to OT intervention were discussed. This review highlights OT specificity in adult CP management.

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Section: Resultsmentioning

confidence: 99%

Occupational Therapy’s Unique Contribution to Chronic Pain Management: A Scoping Review

Lagueux

Dépelteau

Masse

2018

Pain Research and Management

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“…Chronic widespread pain (CWP) is characterized by generalized musculoskeletal pain and often is associated with symptoms such as psychological distress, insomnia, fatigue, and cognitive difficulties. [1][2][3] CWP prevalence is 5% to 10%, with a higher prevalence in women. [4][5][6][7] Chronic pain, including CWP, affects not only patients but also their families and society, leading to significant suffering and high socioeconomic burden.…”

Section: Introductionmentioning

confidence: 99%

Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls—an exploratory case-control study

Gerdle¹,

Wåhlén²,

Ghafouri³

2020

Medicine

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Chronic widespread pain (CWP) is a complex pain condition characterized by generalized musculoskeletal pain and often associated with other symptoms. An important clinical feature is widespread increased pain sensitivity such as lowered pain thresholds for mechanical stimuli (pressure pain thresholds [PPT]). There is a growing interest in investigating the activated neurobiological mechanisms in CWP, which includes fibromyalgia. In CWP, strong significant correlations have been found between muscle protein patterns and PPT. This explorative proteomic study investigates the multivariate correlation pattern between plasma proteins and PPT in CWP and in healthy controls (CON). In addition, this study analyses whether the important proteins for PPT differ between the 2 groups.Using 2-dimensional gel electrophoresis, we analyzed the plasma proteome of the CWP (n = 15) and the CON (n = 23) and proteins were identified using mass spectrometry. For both the CWP and the CON, the associations between the identified proteins and PPT were analyzed using orthogonal partial least square in 2 steps.Significant associations between certain plasma proteins and PPT existed both in CWP (R 2 = 0.95; P = .006) and in CON (R 2 = 0.89; P < .001). For both groups of subjects, we found several proteins involved in PPT that reflect different biological processes. The plasma proteins as well as the biological processes involved in PPT differed markedly between the 2 groups of subjects.This study suggests that plasma protein patterns are associated with pain thresholds in CWP. Using the plasma proteome profile of CWP to study potential biomarker candidates could provide a snapshot of ongoing systemic mechanisms in CWP.Abbreviations: 2-DE = two-dimensional gel electrophoresis, CNS = central nervous system, CON = healthy controls, CV-ANOVA = ANOVA of the cross-validated residuals, CWP = chronic widespread pain, FDR = false discovery rate, FM = fibromyalgia, HADS = hospital anxiety and depression scale, MS = mass spectrometry, MVDA = advanced multivariate analysis, OPLS = orthogonal partial least square regression, PPI = protein-protein interaction, PPT = pressure pain threshold, STRING = search tool for retrieval of interacting genes/proteins, VIP = variable influence on projection.

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“…Chronic widespread pain (CWP), including fibromyalgia syndrome (FMS), is a complex pain condition characterized by generalized musculoskeletal pain and is often associated with symptoms such as tiredness, sleep disturbance, depression, anxiety, and cognitive difficulties ( Wolfe et al, 1990 ; Aparicio et al, 2013 ; Perez de Heredia-Torres et al, 2016 ). Chronic pain not only affects the patients but also affects their families and society, leading to extensive suffering and high economic costs ( Breivik et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain

Wåhlén

Ghafouri

et al. 2018

Front. Psychol.

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Objectives: Although generalized muscle pain, tiredness, anxiety, and depression are commonly present among chronic widespread pain (CWP) patients, the molecular mechanisms behind CWP are not fully elucidated. Moreover, the lack of biomarkers often makes diagnosis and treatment problematic. In this study, we investigated the correlation between pain intensity, psychological distress, and plasma proteins among CWP patients and controls (CON).Methods: The plasma proteome of CWP (n = 15) and CON (n = 23) was analyzed using two-dimensional gel electrophoresis. Orthogonal Partial Least Square analysis (OPLS) was used to determine proteins associated with pain intensity (numeric rating scale) in CWP and psychological distress (Hospital and Depression Scale, HADS) in CWP and CON. Significant proteins were identified by MALDI-TOF and tandem MS.Results: In CWP, pain intensity was associated with plasma proteins mostly involved in metabolic and immunity processes (e.g., kininogen-1, fibrinogen gamma chain, and ceruloplasmin), and psychological distress was associated with plasma proteins related to immunity response, iron ion, and lipid metabolism (e.g., complement factor B, complement C1r subcomponent, hemopexin, and clusterin).Discussion: This study suggests that different plasma protein patterns are associated with different pain intensity and psychological distress in CWP. Proteins belonging to the coagulation cascade and immunity processes showed strong associations to each clinical outcome. Using the plasma proteome profile of CWP to study potential biomarker candidates provides a snapshot of ongoing systemic mechanisms in CWP.

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Cognitive performance in women with fibromyalgia: A case-control study

Abstract: Occupational therapists treating women with fibromyalgia should consider the negative impact of possible cognitive deficits on the performance of daily activities and offer targeted support strategies.

Cited by 14 publications

References 36 publications

Occupational Therapy’s Unique Contribution to Chronic Pain Management: A Scoping Review

Occupational Therapy’s Unique Contribution to Chronic Pain Management: A Scoping Review

Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls—an exploratory case-control study

Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain

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