Cognitive Performance of Individuals With Schizophrenia Across Seven Decades: A Study Using the MATRICS Consensus Cognitive Battery

Rajji, Tarek K.; Voineskos, Aristotle N.; Butters, Meryl A.; Miranda, Dielle; Arenovich, Tamara; Menon, Mahesh; Ismail, Zahinoor; Kern, Robert S.; Mulsant, Benoit H.

doi:10.1016/j.jagp.2012.10.011

Cited by 74 publications

(45 citation statements)

References 39 publications

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“…Patients and comparison healthy individuals were recruited and assessed in clinics and by ads in Pittsburgh (71 patients; 31 comparison healthy individuals) and Toronto (39 patients; 44 comparison healthy individuals). Similar procedures described elsewhere were followed at both sites (36–38). In brief, psychiatric diagnoses were established or ruled out by the Structured Clinical Interview for Axis I DSM-IV Disorders (SCID-IV).…”

Section: Methodsmentioning

confidence: 99%

Oxidative Stress in Older Patients with Bipolar Disorder

Andreazza

Gildengers

Rajji

et al. 2015

The American Journal of Geriatric Psychiatry

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Objective Increases in oxidative stress have been consistently reported in younger patients with bipolar disorder (BD) in postmortem brain and blood samples studies. Changes in oxidative stress are also associated with the natural aging process. Thus, the investigation of oxidative stress across the life span of patients with BD is crucial. Methods We compared the levels of oxidative damage to proteins and lipids in plasma from 110 euthymic older patients with BD I or II (mean ± SD age: 63.9±9.7) and 75 older healthy individuals (66.0 ± 9.6). To assess protein oxidation, we measured the plasma levels of protein carbonyl (PC) and 3-nitrotyrosine (3-NT) using ELISA technique. To assess lipid peroxidation, we measured plasma levels of lipid hydroperoxide (LPH) and 4-hydroxynonenal (4-HNE) using spectrophotometric assays. Results LPH levels were higher in patients than in the comparison healthy individuals, while there were no significant differences for PC, 3-NT and 4-HNE between the two groups. Conclusions The increased levels of an early component of the peroxidation chain, LPH, in euthymic older patients with BD support the hypothesis of a persistent effect of reactive species of oxygen in patients with BD into late life.

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Section: Methodsmentioning

confidence: 99%

Oxidative Stress in Older Patients with Bipolar Disorder

Andreazza

Gildengers

Rajji

et al. 2015

The American Journal of Geriatric Psychiatry

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“…Age of onset is also correlated with different courses of cognitive deterioration [8,9]. Most importantly, it has been shown that age at onset is a stronger determinant of neurocognition and social cognition levels than the age at the time of assessment [9,10].…”

Section: Introductionmentioning

confidence: 99%

Age at the time of onset of psychosis: A marker of specific needs rather than a determinant of outcome?

et al. 2017

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Background: While there is suggestion that early onset of psychosis is a determinant of outcome, knowledge regarding correlates of later onset age is more limited. This study explores the characteristics of patients developing psychosis after age 26, towards the end of the usual age range of early intervention programs, in order to identify potential specific needs of such patients.Methods: 256 early psychosis patients aged 18-35 were followed-up prospectively over 36 months. Patients with onset after 26 ("later onset", LO) were compared to the rest of the sample.Results: LO patients (32% of the sample) had shorter DUP, were less likely to be male, had better premorbid functioning and were more likely to have been exposed to trauma. They had greater insight at presentation and less negative symptoms overall. The trajectories for positive and depressive symptoms were similar in both groups. Evolution of functional level was similar in both groups, but while LO patients recovered faster, they were significantly less likely to return to premorbid functional level. Conclusions:Later psychosis onset correlates with better pre-morbid functioning and higher rate of trauma exposure; the latter should therefore be a treatment focus in such patients. LO patients were less likely to return to premorbid functional level, which suggests that current treatment strategies may not be efficient to help patients maintain employment. The possibility of distinct illness mechanisms according to onset age and the more central role for trauma in patients with onset after age 26 needs to be further explored.

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“…The MCCB has norms for English and Spanish versions in the United States, and co-norming and standardization of the battery are taking place in several other countries (Jedrasik-Styla et al, 2012; Mohn et al, 2012; Rapisarda et al, 2013; Rodriguez-Jimenez et al, 2011). In addition, a number of studies have now reported cognitive domain profiles based on the MCCB in adult patients with schizophrenia (August et al, 2011; Freedman et al, 2008; Javitt et al, 2012; Keefe et al, 2011; Kern et al, 2011; Marx et al, 2009; Pietrzak et al, 2009; Rajji et al, 2013; Shamsi et al, 2011; Silverstein et al, 2010), early-onset schizophrenia-spectrum disorders (Holmen et al, 2009), non-ill siblings (Nam et al, 2009), adolescents with psychotic symptoms (Kelleher et al, 2012), and youth at clinical high-risk for psychosis (De Herdt et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Neuropsychological profile in adult schizophrenia measured with the CMINDS

Erp

Preda

Turner

et al. 2015

Psychiatry Research

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Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS®). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=−1.14), Attention/Vigilance (d=−1.04), Working Memory (d=−1.03), Verbal Learning (d=−1.02), Visual Learning (d=−0.91), and Reasoning/Problem Solving (d=−0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.

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Cognitive Performance of Individuals With Schizophrenia Across Seven Decades: A Study Using the MATRICS Consensus Cognitive Battery

Cited by 74 publications

References 39 publications

Oxidative Stress in Older Patients with Bipolar Disorder

Oxidative Stress in Older Patients with Bipolar Disorder

Age at the time of onset of psychosis: A marker of specific needs rather than a determinant of outcome?

Neuropsychological profile in adult schizophrenia measured with the CMINDS

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