How to design computer interface that facilitates learners' creative thinking can be challenging. This chapter discusses the cognitive processes, the types of divergent thinking, visualization, and brain-functions in relation to human learning. Informed by the research in previous areas, the authors examine the features of computer interface that aligns with brain-functions to support various types of creative thinking. An example is included to demonstrate, at the conceptual level, how computer interface can be leveraged to support learners' creativity, imagination, originality, and expressiveness in learning. Discussions are made with respect to the implication and limitation of the chapter. The chapter concludes with suggestions for future research and studies.