2019
DOI: 10.1212/wnl.0000000000007370
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Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities

Abstract: ObjectiveTo identify distinct cognitive phenotypes in temporal lobe epilepsy (TLE) and evaluate patterns of white matter (WM) network alterations associated with each phenotype.MethodsSeventy patients with TLE were characterized into 4 distinct cognitive phenotypes based on patterns of impairment in language and verbal memory measures (language and memory impaired, memory impaired only, language impaired only, no impairment). Diffusion tensor imaging was obtained in all patients and in 46 healthy controls (HC)… Show more

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Cited by 96 publications
(156 citation statements)
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“…The argument for cognitive phenotypes is that similarly, diverse causes flow into shared neural dysfunctions unified by the presentation of cognitive dysfunction. Different cognitive phenotypes in TLE display unique patterns of microstructural WM compromise …”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…The argument for cognitive phenotypes is that similarly, diverse causes flow into shared neural dysfunctions unified by the presentation of cognitive dysfunction. Different cognitive phenotypes in TLE display unique patterns of microstructural WM compromise …”
Section: Discussionmentioning
confidence: 99%
“…Our study joins the expanding field of studies that have attempted to understand the heterogeneity in cognitive ability by subdividing TLE into cognitive phenotypes and characterizing the neuroanatomical correlates of each subtype. This type of phenotyping could enable a personalized medicine approach to patients for predicting cognitive progression and potentially cognitive decline following surgery . Understanding the shared neurobiology within cognitive phenotypes will be a key aspect in tying together the descriptive and predictive elements of this effort as part of ongoing epilepsy‐wide efforts in subdividing patients to improve treatment decision making …”
Section: Discussionmentioning
confidence: 99%
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