2022
DOI: 10.1007/s10072-022-06130-8
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Cognitive phenotyping of post-infectious SARS-CoV-2 patients

Abstract: Background SARS-CoV-2 infection entails neuroinvasive, neuroinflammatory, and treatment-related features accounting for cognitive deficits in COVID-19-recovered patients. Although screening for such dysfunctions in this population is considered clinically relevant, contributions to cognitive phenotyping including premorbid and disease-related confounders are scarcely represented. This study thus aimed at describing the cognitive outcome at the function-/domain-level of post-infectious SARS-CoV-2 … Show more

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Cited by 10 publications
(5 citation statements)
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References 33 publications
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“…In this respect, it is noteworthy that the only FIM-Cognitive item found to be significantly associated with MoCA scores was the one assessing memory functioning; this finding is indeed in line with memory complaints/deficits being highly reported/detected in COVID-19-recovered individuals ( Søraas et al, 2021 ; Aiello et al, 2022a , c ). In this respect, it should be however noted that this finding might be biased by the fact that the MoCA relevantly loads on memory functions.…”
Section: Discussionsupporting
confidence: 69%
See 1 more Smart Citation
“…In this respect, it is noteworthy that the only FIM-Cognitive item found to be significantly associated with MoCA scores was the one assessing memory functioning; this finding is indeed in line with memory complaints/deficits being highly reported/detected in COVID-19-recovered individuals ( Søraas et al, 2021 ; Aiello et al, 2022a , c ). In this respect, it should be however noted that this finding might be biased by the fact that the MoCA relevantly loads on memory functions.…”
Section: Discussionsupporting
confidence: 69%
“…Disease severity was codified as “asymptomatic,” “mildly symptomatic,” “mild-to-moderate” (requiring O 2 but not ventilation) and “moderate-to-severe” (requiring either non-invasive ventilation or ICU). Patients were classified as previously-at-risk for cognitive decline (RCD+) or not (RCD−) based on remote, recent and COVID-19-related neurological/psychiatric history ( Manera et al, 2022 ; Aiello et al, 2022a , b , c ). Cognition was assessed via the Mini-Mental State Examination (MMSE; Carpinelli Mazzi et al, 2020 ) and the Montreal Cognitive Assessment (MoCA; Aiello et al, 2022d ), whereas functional-ecological outcomes via the Functional Independence Measure (FIM; Linacre et al, 1994 ).…”
Section: Methodsmentioning
confidence: 99%
“…Future studies should aim at overcoming such issues. Moreover, it should be born in mind that the present Neuro± classification, despite having been adopted in previous studies by the present research group [ Aiello et al , 2022a ; 2022c ; 2022d ; Manera et al , 2022 ], suffers from subjectivity. Thereupon, further investigations are needed that aim at identifying a similar classification system that nonetheless is as less subjective as possible…”
Section: Discussionmentioning
confidence: 99%
“…According to Manera et al (2022) and Aiello et al (2022a ; 2022b ; 2022d ), patients were classified, based on remote/recent/COVID-19-related medical records, into being already at risk or not for cognitive/behavioural dysfunctions (Neuro+ vs. Neuro-). Neuro+ groups included patients with: (1) previous neurological ( e.g.…”
Section: Methodsmentioning
confidence: 99%
“…In summary, Perrottelli et al’s systematic review [ 48 ] indicated widespread neurocognitive impairment across a large majority of studies [ 5 , 36 , 42 , 43 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ], although several studies found no significant impairment in COVID-19 patients [ 37 , 45 , 75 , 76 , 77 , 78 , 79 ]. While most assessments used screening tests, providing valuable insights into COVID-19-related neurocognitive impairment, only a few studies employed a comprehensive neuropsychological battery.…”
Section: Introductionmentioning
confidence: 99%